Protein: BRCA2
Breast cancer type 2 susceptibility protein (Fanconi anemia group D1 protein)

Gene: BRCA2
Organism: Homo sapiens
Interactions: 244
UniProt ID: P51587

Gene Ontology (top 5):
GO:0000152 - nuclear ubiquitin ligase complex
GO:0000722 - telomere maintenance via recombination
GO:0000724 - double-strand break repair via homologous recombination
GO:0000781 - chromosome, telomeric region
GO:0000800 - lateral element

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

904277

RAD51
DNA repair protein RAD51 homolog 1

56

10

Small-scale

0.997

High

904269

SEM1
26S proteasome complex subunit SEM1

11

0

Small-scale

0.929

High

219938

XRCC3
DNA repair protein XRCC3

5

10

Small-scale

0.912

High

904286

DMC1
Meiotic recombination protein DMC1/LIM15 homolog

3

10

Small-scale

0.898

High

904260

BRCA2
Breast cancer type 2 susceptibility protein

5

0

Small-scale

0.873

High

904327

PALB2
Partner and localizer of BRCA2

29

1

Small-scale

0.770

High

798864

BRCA1
Breast cancer type 1 susceptibility protein

12

3

Small-scale

0.759

High

904375

FACD2
Fanconi anemia group D2 protein

8

2

Small-scale

0.753

High

219070

RA51C
DNA repair protein RAD51 homolog 3

1

10

Small-scale

0.730

High

904263

PLK1
Serine/threonine-protein kinase PLK1

7

0

Small-scale

0.724

High

904398

HM20B
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related

4

2

Small-scale

0.711

High

413441

P53
Cellular tumor antigen p53

6

0

Small-scale

0.707

High

904405

MO4L1
Mortality factor 4-like protein 1

4

3

Small-scale

0.686

High

664688

CCND1
G1/S-specific cyclin-D1

3

3

Small-scale

0.676

High

904409

HSPB8
Heat shock protein beta-8

3

1

High-throughput

0.675

High

185174

FANCG
Fanconi anemia group G protein

4

0

Small-scale

0.669

High

904290

MO4L2
Mortality factor 4-like protein 2

3

3

Small-scale

0.667

High

904366

BARD1
BRCA1-associated RING domain protein 1

4

0

Small-scale

0.667

High

667663

CDK2
Cyclin-dependent kinase 2

3

1

Small-scale

0.655

High

904267

MLF1
Myeloid leukemia factor 1

3

0

High-throughput

0.638

High

904381

DSN1
Kinetochore-associated protein DSN1 homolog

3

0

High-throughput

0.638

High

904394

NSE4A
Non-structural maintenance of chromosomes element 4 homolog A

3

0

High-throughput

0.638

High

904351

KAT2B
Histone acetyltransferase KAT2B

3

0

Small-scale

0.636

High

904262

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

2

1

Small-scale

0.629

High

904324

SNX32
Sorting nexin-32

2

1

High-throughput

0.628

High

251725

BUB1B
Mitotic checkpoint serine/threonine-protein kinase BUB1 beta

3

0

Small-scale

0.625

High

904389

PDS5B
Sister chromatid cohesion protein PDS5 homolog B

2

0

Small-scale

0.620

High

694968

RFA1
Replication protein A 70 kDa DNA-binding subunit

2

0

Small-scale

0.612

High

354928

CHK2
Serine/threonine-protein kinase Chk2

3

0

Small-scale

0.608

High

904402

BCCIP
BRCA2 and CDKN1A-interacting protein

2

0

Small-scale

0.605

High

336643

BAG4
BAG family molecular chaperone regulator 4

2

0

High-throughput

0.602

High

904310

CNDH2
Condensin-2 complex subunit H2

2

0

High-throughput

0.602

High

904349

PPM1E
Protein phosphatase 1E

2

0

High-throughput

0.602

High

904371

AASD1
Alanyl-tRNA editing protein Aarsd1

2

0

High-throughput

0.602

High

904388

SPNXA
Sperm protein associated with the nucleus on the X chromosome A

2

0

High-throughput

0.602

High

904422

LMBL1
Lethal(3)malignant brain tumor-like protein 1

2

0

High-throughput

0.602

High

858756

BRCC3
Lys-63-specific deubiquitinase BRCC36

2

0

Small-scale

0.595

High

904278

TP53B
TP53-binding protein 1

2

1

Small-scale

0.595

High

904313

DPPA3
Developmental pluripotency-associated protein 3

2

0

Small-scale

0.585

High

904283

KEAP1
Kelch-like ECH-associated protein 1

2

1

Small-scale

0.584

High

904330

SLX4
Structure-specific endonuclease subunit SLX4

2

1

High-throughput

0.584

High

904321

EMSY
BRCA2-interacting transcriptional repressor EMSY

1

1

Small-scale

0.573

High

904406

LIMD1
LIM domain-containing protein 1

1

1

Small-scale

0.573

High

904417

POLH
DNA polymerase eta

1

0

Small-scale

0.571

High

591544

H2AX
Histone H2AX

2

0

Small-scale

0.569

High

588243

RFA2
Replication protein A 32 kDa subunit

2

0

Small-scale

0.563

High

66045

WTIP
Wilms tumor protein 1-interacting protein

1

1

Small-scale

0.561

High

210537

DC1L2
Cytoplasmic dynein 1 light intermediate chain 2

1

1

Small-scale

0.561

High

904273

CCNA1
Cyclin-A1

1

2

Small-scale

0.561

High

904274

SMAD3
Mothers against decapentaplegic homolog 3

1

1

Small-scale

0.561

High

904426

DC1L1
Cytoplasmic dynein 1 light intermediate chain 1

1

1

Small-scale

0.561

High

637408

FLNA
Filamin-A

1

0

Small-scale

0.549

High

861523

NEDD4
E3 ubiquitin-protein ligase NEDD4

2

0

Small-scale

0.539

High

292899

RNH2A
Ribonuclease H2 subunit A

1

0

Small-scale

0.537

High

704729

ERCC5
DNA excision repair protein ERCC-5

1

0

Small-scale

0.537

High

904291

PLEC
Plectin

1

0

Small-scale

0.537

High

904411

UBP21
Ubiquitin carboxyl-terminal hydrolase 21

1

0

Small-scale

0.537

High

269161

HSF2B
Heat shock factor 2-binding protein

1

1

High-throughput

0.536

High

384386

CRYAA
Alpha-crystallin A chain

1

1

High-throughput

0.536

High

461286

HS90A
Heat shock protein HSP 90-alpha

1

2

High-throughput

0.536

High

468196

HS90B
Heat shock protein HSP 90-beta

1

2

High-throughput

0.536

High

761592

HSP74
Heat shock 70 kDa protein 4

1

1

High-throughput

0.536

High

848602

MAGA9
Melanoma-associated antigen 9

1

1

High-throughput

0.536

High

904295

MK06
Mitogen-activated protein kinase 6

1

1

High-throughput

0.536

High

904334

K2C78
Keratin, type II cytoskeletal 78

1

1

High-throughput

0.536

High

904413

SNX6
Sorting nexin-6

1

1

High-throughput

0.536

High

904403

RBL2A
Rab-like protein 2A

2

1

High-throughput

0.533

High

904378

MLP3B
Microtubule-associated protein 1 light chain 3 beta

1

0

High-throughput

0.513

High

158419

RFXK
DNA-binding protein RFXANK

1

0

High-throughput

0.513

High

238449

RAD21
Double-strand-break repair protein rad21 homolog

1

0

Small-scale

0.513

High

281197

CDC45
Cell division control protein 45 homolog

1

0

Small-scale

0.513

High

300737

KRT38
Keratin, type I cuticular Ha8

1

0

High-throughput

0.513

High

550927

PCNA
Proliferating cell nuclear antigen

1

0

Small-scale

0.513

High

777426

K22E
Keratin, type II cytoskeletal 2 epidermal

1

0

High-throughput

0.513

High

904285

SRC8
Src substrate cortactin

1

0

High-throughput

0.513

High

904292

TEBP
Prostaglandin E synthase 3

1

0

High-throughput

0.513

High

904296

UPP1
Uridine phosphorylase 1

1

0

High-throughput

0.513

High

904298

CF184
Cilia- and flagella-associated protein 184

1

0

High-throughput

0.513

High

904302

EFMT2
EEF1A lysine methyltransferase 2

1

0

High-throughput

0.513

High

904354

TRI52
E3 ubiquitin-protein ligase TRIM52

1

0

High-throughput

0.513

High

904365

DNJC7
DnaJ homolog subfamily C member 7

1

0

High-throughput

0.513

High

904370

NAA11
N-alpha-acetyltransferase 11

1

0

High-throughput

0.513

High

904376

DUS16
Dual specificity protein phosphatase 16

1

0

High-throughput

0.513

High

904384

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.513

High

904393

BABA2
BRISC and BRCA1-A complex member 2

1

0

Small-scale

0.513

High

904415

SMC3
Structural maintenance of chromosomes protein 3

1

0

Small-scale

0.513

High

904421

CRYL1
Lambda-crystallin homolog

1

0

High-throughput

0.513

High

172592

XPO1
Exportin-1

1

0

Small-scale

0.505

High

629088

CCNA2
Cyclin-A2

1

2

Small-scale

0.501

High

904279

ATM
Serine-protein kinase ATM

1

2

Small-scale

0.501

High

620217

NUCL
Nucleolin

1

0

High-throughput

0.493

High

904266

RD23A
UV excision repair protein RAD23 homolog A

1

0

Small-scale

0.493

High

904299

KLH40
Kelch-like protein 40

1

2

High-throughput

0.489

High

904425

MAGD1
Melanoma-associated antigen D1

1

1

Small-scale

0.481

High

163071

CHK1
Serine/threonine-protein kinase Chk1

1

0

Small-scale

0.480

High

362217

ABL1
Tyrosine-protein kinase ABL1

1

1

High-throughput

0.479

High

440451

FYN
Tyrosine-protein kinase Fyn

1

1

High-throughput

0.479

High

573394

ENPL
Endoplasmin

1

2

Small-scale

0.479

High

573779

CCNB1
G2/mitotic-specific cyclin-B1

1

2

Small-scale

0.479

High

904264

PMS1
PMS1 protein homolog 1

1

1

High-throughput

0.479

High

904265

PMS2
Mismatch repair endonuclease PMS2

1

1

High-throughput

0.479

High

904271

GRB2
Growth factor receptor-bound protein 2

1

2

High-throughput

0.479

High

904276

TLE3
Transducin-like enhancer protein 3

1

1

High-throughput

0.479

High

904284

DYHC1
Cytoplasmic dynein 1 heavy chain 1

1

1

Small-scale

0.479

High

904287

MDC1
Mediator of DNA damage checkpoint protein 1

1

1

High-throughput

0.479

High

904294

SMAD2
Mothers against decapentaplegic homolog 2

1

1

Small-scale

0.479

High

904317

RUFY3
Protein RUFY3

1

1

Small-scale

0.479

High

904329

SMC5
Structural maintenance of chromosomes protein 5

1

1

High-throughput

0.479

High

904336

MIER2
Mesoderm induction early response protein 2

1

2

High-throughput

0.479

High

904337

NIN
Ninein

1

3

High-throughput

0.479

High

904345

NUP43
Nucleoporin Nup43

1

1

High-throughput

0.479

High

904347

CT55
Cancer/testis antigen 55

1

1

Small-scale

0.479

High

904367

TEP1
Telomerase protein component 1

1

1

Small-scale

0.479

High

904368

LZTS2
Leucine zipper putative tumor suppressor 2

1

2

High-throughput

0.479

High

904412

RCOR1
REST corepressor 1

1

2

High-throughput

0.479

High

904420

NINL
Ninein-like protein

1

2

High-throughput

0.479

High

904423

TRRAP
Transformation/transcription domain-associated protein

1

2

High-throughput

0.479

High

904391

FANCI
Fanconi anemia group I protein

1

0

Small-scale

0.460

High

162927

TERT
Telomerase reverse transcriptase

1

0

Small-scale

0.458

High

193093

DDX3Y
ATP-dependent RNA helicase DDX3Y

1

0

Small-scale

0.458

High

210893

PSMD3
26S proteasome non-ATPase regulatory subunit 3

1

0

Small-scale

0.458

High

246490

KDM1A
Lysine-specific histone demethylase 1A

1

0

High-throughput

0.458

High

270785

ROCK2
Rho-associated protein kinase 2

1

0

Small-scale

0.458

High

283593

SUPT3
Transcription initiation protein SPT3 homolog

1

0

Small-scale

0.458

High

331554

KIF4A
Chromosome-associated kinesin KIF4A

1

0

Small-scale

0.458

High

341538

EYA4
Protein phosphatase EYA4

1

0

High-throughput

0.458

High

358646

LDHA
L-lactate dehydrogenase A chain

1

0

High-throughput

0.458

High

399952

CATA
Catalase

1

0

Small-scale

0.458

High

443724

ATPB
ATP synthase F(1) complex subunit beta, mitochondrial

1

0

High-throughput

0.458

High

446784

NPM
Nucleophosmin

1

0

Small-scale

0.458

High

464880

SP1
Transcription factor Sp1

1

0

Small-scale

0.458

High

539589

PYGM
Glycogen phosphorylase, muscle form

1

0

Small-scale

0.458

High

582719

EZRI
Ezrin

1

0

High-throughput

0.458

High

596862

MGMT
Methylated-DNA--protein-cysteine methyltransferase

1

0

Small-scale

0.458

High

606456

CEBPB
CCAAT/enhancer-binding protein beta

1

0

High-throughput

0.458

High

667220

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

0

Small-scale

0.458

High

697045

APEX1
DNA repair nuclease/redox regulator APEX1

1

0

High-throughput

0.458

High

767737

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.458

High

838346

STA5A
Signal transducer and activator of transcription 5A

1

0

Small-scale

0.458

High

904268

BPIB4
BPI fold-containing family B member 4

1

0

Small-scale

0.458

High

904272

PP2AA
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

1

0

Small-scale

0.458

High

904275

KMT2A
Histone-lysine N-methyltransferase 2A

1

0

High-throughput

0.458

High

904281

HDAC1
Histone deacetylase 1

1

0

High-throughput

0.458

High

904289

PSMD6
26S proteasome non-ATPase regulatory subunit 6

1

0

Small-scale

0.458

High

904293

PTPA
Serine/threonine-protein phosphatase 2A activator

1

0

Small-scale

0.458

High

904297

CL16A
Protein CLEC16A

1

0

High-throughput

0.458

High

904300

C19L2
CWF19-like protein 2

1

0

Small-scale

0.458

High

904303

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

0

Small-scale

0.458

High

904305

CELF3
CUGBP Elav-like family member 3

1

0

Small-scale

0.458

High

904307

DCA12
DDB1- and CUL4-associated factor 12

1

0

High-throughput

0.458

High

904308

UT14C
U3 small nucleolar RNA-associated protein 14 homolog C

1

0

Small-scale

0.458

High

904309

CP135
Centrosomal protein of 135 kDa

1

0

High-throughput

0.458

High

904312

CF299
Cilia- and flagella-associated protein 299

1

0

Small-scale

0.458

High

904316

BNC2
Zinc finger protein basonuclin-2

1

0

Small-scale

0.458

High

904319

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

0

High-throughput

0.458

High

904320

MYH14
Myosin-14

1

0

Small-scale

0.458

High

904322

DPOLN
DNA polymerase nu

1

0

Small-scale

0.458

High

904323

SHLD2
Shieldin complex subunit 2

1

0

Small-scale

0.458

High

904325

DGKH
Diacylglycerol kinase eta

1

0

Small-scale

0.458

High

904328

ASXL1
Polycomb group protein ASXL1

1

0

High-throughput

0.458

High

904332

RN168
E3 ubiquitin-protein ligase RNF168

1

0

Small-scale

0.458

High

904333

SYCP3
Synaptonemal complex protein 3

1

0

Small-scale

0.458

High

904343

FXL13
F-box and leucine-rich repeat protein 13

1

0

Small-scale

0.458

High

904344

MCPH1
Microcephalin

1

0

Small-scale

0.458

High

904352

RAD50
DNA repair protein RAD50

1

0

Small-scale

0.458

High

904355

PF21A
PHD finger protein 21A

1

0

High-throughput

0.458

High

904356

ZN707
Zinc finger protein 707

1

0

Small-scale

0.458

High

904357

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

0

High-throughput

0.458

High

904358

DTBP1
Dysbindin

1

0

High-throughput

0.458

High

904359

ZN503
Zinc finger protein 503

1

0

Small-scale

0.458

High

904361

AURKB
Aurora kinase B

1

0

Small-scale

0.458

High

904362

NSL1
Kinetochore-associated protein NSL1 homolog

1

0

High-throughput

0.458

High

904372

IER2
Immediate early response gene 2 protein

1

0

High-throughput

0.458

High

904374

FANCJ
Fanconi anemia group J protein

1

0

Small-scale

0.458

High

904379

RPA49
DNA-directed RNA polymerase I subunit RPA49

1

0

High-throughput

0.458

High

904382

CHM4B
Charged multivesicular body protein 4b

1

0

Small-scale

0.458

High

904385

FANCE
Fanconi anemia group E protein

1

0

Small-scale

0.458

High

904395

ETAA1
Ewing's tumor-associated antigen 1

1

0

Small-scale

0.458

High

904396

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

0

High-throughput

0.458

High

904400

MDFIC
MyoD family inhibitor domain-containing protein

1

0

Small-scale

0.458

High

904404

ASH2L
Set1/Ash2 histone methyltransferase complex subunit ASH2

1

0

High-throughput

0.458

High

904407

EI2BD
Translation initiation factor eIF2B subunit delta

1

0

Small-scale

0.458

High

904408

ANC2
Anaphase-promoting complex subunit 2

1

0

High-throughput

0.458

High

904410

VPS28
Vacuolar protein sorting-associated protein 28 homolog

1

0

High-throughput

0.458

High

904414

TTF2
Transcription termination factor 2

1

0

Small-scale

0.458

High

904416

MTMR6
Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR6

1

0

Small-scale

0.458

High

904418

ASF1A
Histone chaperone ASF1A

1

0

High-throughput

0.458

High

904419

CARD8
Caspase recruitment domain-containing protein 8

1

0

High-throughput

0.458

High

904424

SHAN1
SH3 and multiple ankyrin repeat domains protein 1

1

0

Small-scale

0.458

High

316787

MTA2
Metastasis-associated protein MTA2

1

2

Small-scale

0.445

High

872092

SOX2
Transcription factor SOX-2

1

1

High-throughput

0.445

High

155196

NCKP5
Nck-associated protein 5

1

1

Small-scale

0.437

High

904335

CFA52
Cilia- and flagella-associated protein 52

1

1

Small-scale

0.437

High

904397

DYH9
Dynein axonemal heavy chain 9

1

1

Small-scale

0.437

High

536781

HSP7C
Heat shock cognate 71 kDa protein

1

0

High-throughput

0.426

High

904326

STX12
Syntaxin-12

1

0

High-throughput

0.426

High

904363

NEUL4
Neuralized-like protein 4

1

0

High-throughput

0.426

High

904392

TRM1
tRNA

1

0

High-throughput

0.426

High

904280

ATR
Serine/threonine-protein kinase ATR

1

2

Small-scale

0.408

High

85421

B7ZBD5
RAB, member of RAS oncogene family like 2A

1

1

High-throughput

0.407

High

904304

CF141
Uncharacterized protein C6orf141

2

0

High-throughput

0.328

High

904342

SAXO5
Stabilizer of axonemal microtubules 5

2

0

High-throughput

0.328

High

904353

CNKR1
Connector enhancer of kinase suppressor of ras 1

2

0

High-throughput

0.328

High

904301

T10IP
Testis-specific protein 10-interacting protein

1

0

High-throughput

0.279

Low

904340

PRLD2
PRELI domain-containing protein 2

1

0

High-throughput

0.279

Low

904360

BORC8
BLOC-1-related complex subunit 8

1

0

High-throughput

0.279

Low

904364

TCPQM
T-complex protein 1 subunit theta-like 2

1

0

High-throughput

0.279

Low

895513

SERPH
Serpin H1

1

0

Small-scale

0.261

Low

904390

UQCC1
Ubiquinol-cytochrome c reductase complex assembly factor 1

1

0

Small-scale

0.261

Low

354005

PPR17
Protein phosphatase 1 regulatory subunit 17

1

0

Small-scale

0.249

Low

361574

FA8
Coagulation factor VIII

1

0

Small-scale

0.249

Low

472287

CFAH
Complement factor H

1

0

Small-scale

0.249

Low

480405

MMP10
Stromelysin-2

1

0

Small-scale

0.249

Low

551734

COBA1

1

0

Small-scale

0.249

Low

635655

ASPG
N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase

1

0

Small-scale

0.249

Low

770834

OPRM
Mu-type opioid receptor

1

0

Small-scale

0.249

Low

904270

RAB5B
Ras-related protein Rab-5B

1

0

High-throughput

0.249

Low

904282

TRI29
Tripartite motif-containing protein 29

1

0

Small-scale

0.249

Low

904288

MF13A
Transmembrane protein 180

1

0

Small-scale

0.249

Low

904306

DCST2
DC-STAMP domain-containing protein 2

1

0

Small-scale

0.249

Low

904311

GP179
Probable G-protein coupled receptor 179

1

0

Small-scale

0.249

Low

904314

ZY11A
Protein zyg-11 homolog A

1

0

Small-scale

0.249

Low

904315

SYNE3
Nesprin-3

1

0

High-throughput

0.249

Low

904318

MOT14
Monocarboxylate transporter 14

1

0

Small-scale

0.249

Low

904338

CCD24
Coiled-coil domain-containing protein 24

1

0

Small-scale

0.249

Low

904339

TO6BL
Type 2 DNA topoisomerase 6 subunit B-like

1

0

Small-scale

0.249

Low

904346

CLHC1
Clathrin heavy chain linker domain-containing protein 1

1

0

Small-scale

0.249

Low

904348

DYDC1
DPY30 domain-containing protein 1

1

0

Small-scale

0.249

Low

904350

FIG4
Polyphosphoinositide phosphatase

1

0

Small-scale

0.249

Low

904369

CAB45
45 kDa calcium-binding protein

1

0

High-throughput

0.249

Low

904373

CABL2
CDK5 and ABL1 enzyme substrate 2

1

0

Small-scale

0.249

Low

904377

GRB1L
GREB1-like protein

1

0

Small-scale

0.249

Low

904380

IPYR2
Inorganic pyrophosphatase 2, mitochondrial

1

0

Small-scale

0.249

Low

904383

FZD8
Frizzled-8

1

0

Small-scale

0.249

Low

904386

SO1B3
Solute carrier organic anion transporter family member 1B3

1

0

Small-scale

0.249

Low

904387

STRN4
Striatin-4

1

0

Small-scale

0.249

Low

904401

RELCH
RAB11-binding protein RELCH

1

0

Small-scale

0.249

Low

87381

OSCRI
SCRIB overlapping open reading frame protein

1

0

High-throughput

0.232

Low

511033

PNM6A
Paraneoplastic antigen-like protein 6A

1

0

High-throughput

0.232

Low

904261

GPC3
Glypican-3

1

0

High-throughput

0.232

Low

904331

KATL2
Katanin p60 ATPase-containing subunit A-like 2

1

0

High-throughput

0.232

Low

904341

GG6L2
Golgin subfamily A member 6-like protein 2

1

0

High-throughput

0.232

Low

904399

PP4RL
Putative serine/threonine-protein phosphatase 4 regulatory subunit 1-like

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025