HitPredict

Interactor 1: PP1A (P62136)
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit (PP-1A) (EC 3.1.3.16)
Gene: PPP1CA

Interactor 2: B2CL1 (Q07817)
Bcl-2-like protein 1 (Bcl2-L-1) (Apoptosis regulator Bcl-X)
Gene: BCL2L1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.67	0.60	0.634

Property	Details
Experiments	12115603, 17274640
Identification Methods	affinity chromatography technology, pull down, antibody array
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 330 Hs			1 233
+	Hs
		737765 PP1G_HUMAN (1-330): 0: 579: 90.66		B2CL1_HUMAN (1-233): 2.85e-101: 295: 100.00
+	Mm
		926544 PP1G_MOUSE (1-330): 0: 579: 90.66		B2CL1_MOUSE (1-233): 3.12e-94: 277: 97.85
+	Mm
		489480 PP1A_MOUSE (1-330): 0: 614: 99.70		BCL2_MOUSE (5-231): 1.12e-75: 230: 42.98
+	Hs
		489393 PP1A_HUMAN (1-330): 0: 614: 100.00		BCL2_HUMAN (5-231): 3.01e-71: 219: 44.16
+	Mm
		489481 PP1G_MOUSE (1-330): 0: 579: 90.66		BCL2_MOUSE (5-231): 1.12e-75: 230: 42.98
+	Hs
		489378 PP1G_HUMAN (1-330): 0: 579: 90.66		BCL2_HUMAN (5-231): 3.01e-71: 219: 44.16
+	Hs
		489394 PP1B_HUMAN (1-330): 0: 568: 87.88		BCL2_HUMAN (5-231): 3.01e-71: 219: 44.16
+	Hs
		905851 PP1A_HUMAN (1-330): 0: 614: 100.00		BAX_HUMAN (28-198): 7.18e-52: 168: 22.99
+	Hs
		906060 PP1A_HUMAN (1-330): 0: 614: 100.00		B2CL2_HUMAN (6-231): 3.69e-51: 166: 39.38
+	Mm
		926536 PP1G_MOUSE (1-330): 0: 579: 90.66		BAX_MOUSE (28-198): 3.25e-51: 166: 24.14
+	Hs
		489398 PP2AA_HUMAN (8-302): 3.14e-176: 492: 47.30		BCL2_HUMAN (5-231): 3.01e-71: 219: 44.16