Protein: SCN5A
Sodium channel protein type 5 subunit alpha (Sodium channel protein cardiac muscle subunit alpha) (Sodium channel protein type V subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.5) (hH1)

Gene: SCN5A
Organism: Homo sapiens
Interactions: 39
UniProt ID: Q14524

Gene Ontology (top 5):
GO:0001518 - voltage-gated sodium channel complex
GO:0002027 - regulation of heart rate
GO:0003161 - cardiac conduction system development
GO:0003231 - cardiac ventricle development
GO:0003360 - brainstem development

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

861611

NEDD4
E3 ubiquitin-protein ligase NEDD4

3

20

Small-scale

0.664

High

1127630

FGF13
Fibroblast growth factor 13

3

7

Small-scale

0.656

High

1127634

NED4L
E3 ubiquitin-protein ligase NEDD4-like

3

20

Small-scale

0.646

High

961173

FGF12
Fibroblast growth factor 12

2

7

Small-scale

0.639

High

1104785

SNTA1
Alpha-1-syntrophin

2

12

Small-scale

0.602

High

1127633

ZMY19
Zinc finger MYND domain-containing protein 19

2

0

High-throughput

0.589

High

1110439

KCC2D
Calcium/calmodulin-dependent protein kinase type II subunit delta

1

7

Small-scale

0.586

High

1127627

BANP
Protein BANP

2

0

High-throughput

0.580

High

684001

PTN3
Tyrosine-protein phosphatase non-receptor type 3

1

10

Small-scale

0.552

High

384671

CRYAB
Alpha-crystallin B chain

1

0

Small-scale

0.549

High

1127631

FGF11
Fibroblast growth factor 11

2

7

High-throughput

0.549

High

390044

ALBU
Albumin

1

2

High-throughput

0.536

High

1127641

SNTG2
Gamma-2-syntrophin

1

11

Small-scale

0.506

High

132037

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

20

Small-scale

0.501

High

667850

CDK2
Cyclin-dependent kinase 2

1

1

Small-scale

0.501

High

1091397

ANK3
Ankyrin-3

1

5

Small-scale

0.501

High

1127640

SMUF2
E3 ubiquitin-protein ligase SMURF2

1

20

High-throughput

0.501

High

1127632

FGF14
Fibroblast growth factor 14

1

7

High-throughput

0.489

High

1127629

ANS1A
Ankyrin repeat and SAM domain-containing protein 1A

1

10

High-throughput

0.481

High

903156

SMCA2
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2

1

1

High-throughput

0.479

High

941347

CAV3
Caveolin-3

1

3

Small-scale

0.479

High

1091493

DLG1
Disks large homolog 1

1

3

Small-scale

0.479

High

1104823

SNTB2
Beta-2-syntrophin

1

10

Small-scale

0.479

High

1118432

SNTB1
Beta-1-syntrophin

1

10

Small-scale

0.479

High

1127636

LITAF
Lipopolysaccharide-induced tumor necrosis factor-alpha factor

1

1

Small-scale

0.479

High

1127637

ANM1
Protein arginine N-methyltransferase 1

1

2

Small-scale

0.479

High

1127638

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

8

High-throughput

0.479

High

1127623

Q49AR9
ANKS1A protein

1

2

High-throughput

0.470

High

1127626

GPD1L
Glycerol-3-phosphate dehydrogenase 1-like protein

1

0

Small-scale

0.458

High

170763

CLGN
Calmegin

1

2

High-throughput

0.445

High

1127625

AGRG5
Adhesion G-protein coupled receptor G5

1

8

High-throughput

0.445

High

1127635

S1PR3
Sphingosine 1-phosphate receptor 3

1

2

High-throughput

0.445

High

1127642

FZD10
Frizzled-10

1

4

High-throughput

0.445

High

833413

RGS2
Regulator of G-protein signaling 2

1

0

High-throughput

0.438

High

253503

ANM3
Protein arginine N-methyltransferase 3

1

2

Small-scale

0.437

High

1127639

GAN
Gigaxonin

1

5

High-throughput

0.437

High

1127624

CMTD1
Catechol O-methyltransferase domain-containing protein 1

1

0

High-throughput

0.426

High

1127628

TEKT4
Tektin-4

2

0

High-throughput

0.316

High

1127643

EMC9
ER membrane protein complex subunit 9

2

0

High-throughput

0.316

High


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Last updated: 11Aug2025