HitPredict

Interactor 1: PRS8 (P62195)
26S proteasome regulatory subunit 8 (26S proteasome AAA-ATPase subunit RPT6) (Proteasome 26S subunit ATPase 5) (Proteasome subunit p45) (Thyroid hormone receptor-interacting protein 1) (TRIP1) (p45/SUG)
Gene: PSMC5

Interactor 2: ECM29 (Q5VYK3)
Proteasome adapter and scaffold protein ECM29 (Ecm29 proteasome adapter and scaffold) (Proteasome-associated protein ECM29 homolog)
Gene: ECPAS

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	28821611, 35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000502 - proteasome complex GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0016020 - membrane and 1 others more... GO:0031410 - cytoplasmic vesicle
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 406 Hs			1 1845
+	Hs
		906856 PRS4_HUMAN (4-396): 7.85e-130: 382: 46.31		ECM29_HUMAN (1-1845): 0: 1279: 100.00
+	Hs
		798694 PRS6B_HUMAN (1-399): 6.4e-122: 361: 41.86		ECM29_HUMAN (1-1845): 0: 1279: 100.00
+	Hs
		730285 PRS7_HUMAN (84-392): 1.21e-115: 345: 56.31		ECM29_HUMAN (1-1845): 0: 1279: 100.00
+	Hs
		913292 PRS10_HUMAN (8-101): 2.13e-10: 64: 10.64		ECM29_HUMAN (1-1845): 0: 1279: 100.00
+	Sc
		703893 PRS7_YEAST (84-391): 1.53e-111: 336: 54.87		ECM29_YEAST (4-1740): 0: 678: 22.25
+	Sc
		753435 PRS8_YEAST (8-110): 1.31e-09: 61.7: 7.77		ECM29_YEAST (4-1740): 0: 678: 22.25
+	Rn
		907220 PRS8_RAT (1-406): 1.42e-136: 398: 100.00		CAND1_RAT (282-1301): 1.86e-34: 146: 12.77
+	Rn
		956841 PRS7_RAT (84-392): 1.59e-114: 343: 55.99		CAND1_RAT (282-1301): 1.86e-34: 146: 12.77
+	Sc
		561052 PRS8_YEAST (8-110): 1.31e-09: 61.7: 7.77		EF3A_YEAST (1093-1349): 9.8e-14: 79.2: 17.11