HitPredict

Interactor 1: PRS8 (P62195)
26S proteasome regulatory subunit 8 (26S proteasome AAA-ATPase subunit RPT6) (Proteasome 26S subunit ATPase 5) (Proteasome subunit p45) (Thyroid hormone receptor-interacting protein 1) (TRIP1) (p45/SUG)
Gene: PSMC5

Interactor 2: RORB (Q92753)
Nuclear receptor ROR-beta (Nuclear receptor RZR-beta) (Nuclear receptor subfamily 1 group F member 2) (Retinoid-related orphan receptor-beta)
Gene: RORB

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.44	0.60	0.515

Property	Details
Experiments	unassigned1304
Identification Methods	two hybrid prey pooling approach, two hybrid array, validated two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006357 - regulation of transcription by RNA polymerase II GO:0045892 - negative regulation of DNA-templated transcription GO:0045893 - positive regulation of DNA-templated transcription
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 406 Hs			1 470
+	Hs
		907055 PRS8_HUMAN (1-406): 1.42e-136: 398: 100.00		Q58EY0_HUMAN (14-470): 3.31e-134: 396: 100.00
+	Hs
		798685 PRS6B_HUMAN (1-399): 6.4e-122: 361: 41.86		Q58EY0_HUMAN (14-470): 3.31e-134: 396: 100.00
+	Hs
		723175 PRS8_HUMAN (1-406): 1.42e-136: 398: 100.00		RORA_HUMAN (8-464): 7.15e-112: 341: 58.86
+	Hs
		846406 PRS8_HUMAN (1-406): 1.42e-136: 398: 100.00		RORG_HUMAN (3-465): 3.01e-105: 324: 45.92
+	Hs
		823807 PRS8_HUMAN (1-406): 1.42e-136: 398: 100.00		NR2C2_HUMAN (4-458): 3.08e-103: 321: 19.67
+	Hs
		823806 PRS4_HUMAN (4-396): 7.85e-130: 382: 46.31		NR2C2_HUMAN (4-458): 3.08e-103: 321: 19.67
+	Hs
		798611 PRS6B_HUMAN (1-399): 6.4e-122: 361: 41.86		NR2C2_HUMAN (4-458): 3.08e-103: 321: 19.67
+	Hs
		730213 PRS7_HUMAN (84-392): 1.21e-115: 345: 56.31		NR2C2_HUMAN (4-458): 3.08e-103: 321: 19.67
+	Hs
		509930 PRS8_HUMAN (1-406): 1.42e-136: 398: 100.00		VDR_HUMAN (1-464): 5.39e-84: 266: 20.43
+	Hs
		265859 PRS8_HUMAN (1-406): 1.42e-136: 398: 100.00		NR1I2_HUMAN (2-463): 1.18e-81: 261: 22.51
+	Hs
		906997 PRS8_HUMAN (1-406): 1.42e-136: 398: 100.00		PPARD_HUMAN (10-461): 2.88e-72: 236: 20.40
+	Hs
		740491 PRS4_HUMAN (4-396): 7.85e-130: 382: 46.31		PPARG_HUMAN (5-461): 2.72e-77: 251: 22.34
+	Hs
		500362 PRS8_HUMAN (1-406): 1.42e-136: 398: 100.00		RARB_HUMAN (20-149): 2.43e-46: 168: 42.31
+	Hs
		530791 PRS8_HUMAN (1-406): 1.42e-136: 398: 100.00		RARG_HUMAN (20-95): 4.04e-45: 165: 63.16
+	Hs
		487934 PRS8_HUMAN (1-406): 1.42e-136: 398: 100.00		RARA_HUMAN (20-95): 1.36e-43: 161: 61.84
+	Hs
		587150 PRS8_HUMAN (1-406): 1.42e-136: 398: 100.00		RXRA_HUMAN (21-102): 5.1e-28: 117: 57.32
+	Hs
		823822 PRS10_HUMAN (8-101): 2.13e-10: 64: 10.64		NR2C2_HUMAN (4-458): 3.08e-103: 321: 19.67