Protein: TTYH3
Protein tweety homolog 3 (hTTY3) (Volume-regulated anion channel subunit TTYH3)

Gene: TTYH3
Organism: Homo sapiens
Interactions: 78
UniProt ID: Q9C0H2

Gene Ontology (top 5):
GO:0005229 - intracellularly calcium-gated chloride channel activity
GO:0005254 - chloride channel activity
GO:0005509 - calcium ion binding
GO:0005886 - plasma membrane
GO:0006821 - chloride transport

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

689854

CD27
CD27 antigen

3

1

High-throughput

0.667

High

1421250

P2Y12
P2Y purinoceptor 12

3

6

High-throughput

0.667

High

638241

S1PR1
Sphingosine 1-phosphate receptor 1

3

11

High-throughput

0.662

High

456010

ASGR2
Asialoglycoprotein receptor 2

3

0

High-throughput

0.638

High

1421251

PACC1
Proton-activated chloride channel

3

0

High-throughput

0.634

High

622678

TNR1A
Tumor necrosis factor receptor superfamily member 1A

2

1

High-throughput

0.628

High

669064

FPR2
N-formyl peptide receptor 2

2

6

High-throughput

0.628

High

845540

PI2R
Prostacyclin receptor

2

2

High-throughput

0.628

High

1279490

GP141
Probable G-protein coupled receptor 141

2

5

High-throughput

0.628

High

1334409

UXS1
UDP-glucuronic acid decarboxylase 1

2

1

High-throughput

0.628

High

1291483

RETR3
Reticulophagy regulator 3

3

1

High-throughput

0.609

High

1409632

DHRS9
Dehydrogenase/reductase SDR family member 9

3

2

High-throughput

0.609

High

749273

CD70
CD70 antigen

2

0

High-throughput

0.602

High

733065

VIPR1
Vasoactive intestinal polypeptide receptor 1

2

3

High-throughput

0.601

High

1153431

CD226
CD226 antigen

2

1

High-throughput

0.601

High

861767

NEDD4
E3 ubiquitin-protein ligase NEDD4

2

2

Small-scale

0.595

High

1421248

TTYH3
Protein tweety homolog 3

1

2

Small-scale

0.584

High

862430

YAP1
Transcriptional coactivator YAP1

2

5

High-throughput

0.571

High

166035

FFAR1
Free fatty acid receptor 1

1

3

High-throughput

0.536

High

170949

CLGN
Calmegin

1

1

High-throughput

0.536

High

351960

S1PR4
Sphingosine 1-phosphate receptor 4

1

11

High-throughput

0.536

High

701432

5HT1B
5-hydroxytryptamine receptor 1B

1

2

High-throughput

0.536

High

711591

NK3R
Neuromedin-K receptor

1

1

High-throughput

0.536

High

833866

P2RY2
P2Y purinoceptor 2

1

6

High-throughput

0.536

High

870781

CXA8
Gap junction alpha-8 protein

1

2

High-throughput

0.536

High

878087

AGRE5
Adhesion G protein-coupled receptor E5

1

3

High-throughput

0.536

High

907054

CCR6
C-C chemokine receptor type 6

1

3

High-throughput

0.536

High

914340

EFNA4
Ephrin-A4

1

1

High-throughput

0.536

High

1101658

GPR17
Uracil nucleotide/cysteinyl leukotriene receptor

1

5

High-throughput

0.536

High

1350057

SPP2B
Signal peptide peptidase-like 2B

1

1

High-throughput

0.536

High

1366218

LPAR1
Lysophosphatidic acid receptor 1

1

10

High-throughput

0.536

High

1421253

LPAR2
Lysophosphatidic acid receptor 2

1

11

High-throughput

0.536

High

1421254

GPR35
G-protein coupled receptor 35

1

5

High-throughput

0.536

High

1421255

GPR27
Probable G-protein coupled receptor 27

1

4

High-throughput

0.536

High

1421258

PILRB
Paired immunoglobulin-like type 2 receptor beta

1

1

High-throughput

0.536

High

252629

TSN2
Tetraspanin-2

1

0

High-throughput

0.513

High

438100

GLPB
Glycophorin-B

1

0

High-throughput

0.513

High

820579

GPV
Platelet glycoprotein V

1

0

High-throughput

0.513

High

904440

CP2J2
Cytochrome P450 2J2

1

0

High-throughput

0.513

High

947905

T2R19
Taste receptor type 2 member 19

1

0

High-throughput

0.513

High

1309419

CA210
Type III endosome membrane protein TEMP

1

0

High-throughput

0.513

High

1417370

CCG6
Voltage-dependent calcium channel gamma-6 subunit

1

0

High-throughput

0.513

High

1421257

HCST
Hematopoietic cell signal transducer

1

0

High-throughput

0.513

High

1394605

ITCH
E3 ubiquitin-protein ligase Itchy homolog

1

2

High-throughput

0.501

High

1053834

KDSR
3-ketodihydrosphingosine reductase

1

2

High-throughput

0.489

High

691845

MK03
Mitogen-activated protein kinase 3

1

0

High-throughput

0.486

High

508580

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

1

High-throughput

0.479

High

1090004

LMAN2
Vesicular integral-membrane protein VIP36

1

1

High-throughput

0.479

High

1155184

EREP1
Endosomal transmembrane epsin interactor 1

1

1

High-throughput

0.479

High

1164081

PTPRN
Receptor-type tyrosine-protein phosphatase-like N

1

1

High-throughput

0.479

High

463752

LYN
Tyrosine-protein kinase Lyn

1

0

Small-scale

0.458

High

190256

MOT4
Monocarboxylate transporter 4

1

1

High-throughput

0.445

High

255203

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

2

High-throughput

0.445

High

907112

CCR9
C-C chemokine receptor type 9

1

4

High-throughput

0.445

High

1359495

CTL1
Choline transporter-like protein 1

1

2

High-throughput

0.445

High

1334548

RN149
E3 ubiquitin-protein ligase RNF149

1

1

High-throughput

0.437

High

1329188

S15A4
Solute carrier family 15 member 4

1

0

High-throughput

0.426

High

1401111

MAGI1
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1

1

0

High-throughput

0.426

High

1421249

S6A16
Orphan sodium- and chloride-dependent neurotransmitter transporter NTT5

1

0

High-throughput

0.426

High

1357372

NAT14
Probable N-acetyltransferase 14

1

1

High-throughput

0.407

High

1358022

TM171
Transmembrane protein 171

3

0

High-throughput

0.347

High

1218473

CDKAL
Threonylcarbamoyladenosine tRNA methylthiotransferase

2

0

High-throughput

0.328

High

1288450

SO6A1
Solute carrier organic anion transporter family member 6A1

2

0

High-throughput

0.328

High

71247

HIDE1
Protein HIDE1

1

0

High-throughput

0.279

Low

253896

TPST2
Protein-tyrosine sulfotransferase 2

1

0

High-throughput

0.279

Low

946384

SIM11
Small integral membrane protein 11

1

0

High-throughput

0.279

Low

1022465

IDD
Integral membrane protein DGCR2/IDD

1

0

High-throughput

0.279

Low

1200371

KCP3
Keratinocyte-associated protein 3

1

0

High-throughput

0.279

Low

1256850

GOT1A
Vesicle transport protein GOT1A

1

0

High-throughput

0.279

Low

1291678

CMTD1
Catechol O-methyltransferase domain-containing protein 1

1

0

High-throughput

0.279

Low

1315480

K2013
Uncharacterized protein KIAA2013

1

0

High-throughput

0.279

Low

1412307

TMM79
Transmembrane protein 79

1

0

High-throughput

0.279

Low

1421252

IPPK
Inositol-pentakisphosphate 2-kinase

1

0

High-throughput

0.279

Low

1005073

RNF4
E3 ubiquitin-protein ligase RNF4

1

0

High-throughput

0.249

Low

1255439

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

1276305

ATG9A
Autophagy-related protein 9A

1

0

High-throughput

0.249

Low

1421256

MFRN1
Mitoferrin-1

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025