HitPredict

Interactor 1: PP1B (P62207)
Serine/threonine-protein phosphatase PP1-beta catalytic subunit (PP-1B) (EC 3.1.3.16) (EC 3.1.3.53)
Gene: PPP1CB

Interactor 2: MYPT1 (Q90623)
Protein phosphatase 1 regulatory subunit 12A (130 kDa myosin-binding subunit of smooth muscle myosin phosphatase) (Myosin phosphatase-targeting subunit 1) (Myosin phosphatase target subunit 1) (PP1M subunit M110) (Protein phosphatase myosin-binding subunit)
Gene: PPP1R12A

Species: Gallus gallus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	15164081
Identification Methods	x-ray crystallography
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0030155 - regulation of cell adhesion GO:0072357 - PTW/PP1 phosphatase complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 327 Gg			1 1004
+	Hs
		161348 PP1B_HUMAN (1-327): 0: 597: 100.00		MYPT1_HUMAN (1-1001): 4.4e-134: 431: 83.27
+	Hs
		161347 PP1A_HUMAN (1-326): 0: 576: 88.79		MYPT1_HUMAN (1-1001): 4.4e-134: 431: 83.27
+	Mm
		906366 PP1A_MOUSE (1-326): 0: 576: 88.49		MYPT1_MOUSE (1-1001): 1.62e-125: 408: 78.14
+	Mm
		926555 PP1G_MOUSE (1-327): 0: 569: 86.89		MYPT1_MOUSE (1-1001): 1.62e-125: 408: 78.14
+	Hs
		906561 PP1B_HUMAN (1-327): 0: 597: 100.00		PP16A_HUMAN (2-308): 6.92e-82: 277: 37.27
+	Hs
		906617 PP1B_HUMAN (1-327): 0: 597: 100.00		RAI14_HUMAN (30-992): 5.05e-74: 265: 14.68
+	Hs
		906079 PP1A_HUMAN (1-326): 0: 576: 88.79		PP16A_HUMAN (2-308): 6.92e-82: 277: 37.27
+	Hs
		906572 PP1B_HUMAN (1-327): 0: 597: 100.00		PP16B_HUMAN (2-520): 6.4e-72: 251: 26.13
+	Hs
		906099 PP1A_HUMAN (1-326): 0: 576: 88.79		PP16B_HUMAN (2-520): 6.4e-72: 251: 26.13
+	Hs
		3260 PP1B_HUMAN (1-327): 0: 597: 100.00		A0A0S2Z4Q8_HUMAN (2-163): 4.58e-61: 207: 64.33
+	Hs
		906005 PP1A_HUMAN (1-326): 0: 576: 88.79		MIB1_HUMAN (1-238): 2.69e-37: 153: 19.77
+	Ce
		953872 GLC7A_CAEEL (3-317): 0: 569: 92.38		P90902_CAEEL (44-298): 2.46e-36: 145: 37.21
+	Hs
		906585 PP1B_HUMAN (1-327): 0: 597: 100.00		PP12C_HUMAN (542-983): 9.23e-24: 110: 17.32
+	Hs
		225133 PP1B_HUMAN (1-327): 0: 597: 100.00		MYPT2_HUMAN (1-942): 3.32e-23: 108: 11.92
+	Hs
		906517 PP1B_HUMAN (1-327): 0: 597: 100.00		PPR27_HUMAN (36-152): 6.33e-21: 92.4: 43.22
+	Hs
		906116 PP1A_HUMAN (1-326): 0: 576: 88.79		PP12C_HUMAN (542-983): 9.23e-24: 110: 17.32
+	Hs
		225132 PP1A_HUMAN (1-326): 0: 576: 88.79		MYPT2_HUMAN (1-942): 3.32e-23: 108: 11.92
+	Mm
		906293 PP1A_MOUSE (1-326): 0: 576: 88.49		MYPT2_MOUSE (1-893): 7.33e-23: 107: 11.40
+	Mm
		906252 PP1A_MOUSE (1-326): 0: 576: 88.49		PP12C_MOUSE (541-983): 9.27e-21: 100: 16.56
+	Hs
		906000 PP1A_HUMAN (1-326): 0: 576: 88.79		PPR27_HUMAN (36-152): 6.33e-21: 92.4: 43.22