Protein: GNS
N-acetylglucosamine-6-sulfatase (EC 3.1.6.14) (Glucosamine-6-sulfatase) (G6S)

Gene: GNS
Organism: Homo sapiens
Interactions: 42
UniProt ID: P15586

Gene Ontology (top 5):
GO:0005539 - glycosaminoglycan binding
GO:0005576 - extracellular region
GO:0006027 - glycosaminoglycan catabolic process
GO:0008449 - N-acetylglucosamine-6-sulfatase activity
GO:0008484 - sulfuric ester hydrolase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

584965

SULF2
Extracellular sulfatase Sulf-2

2

7

High-throughput

0.811

High

548403

MPRI
Cation-independent mannose-6-phosphate receptor

2

7

High-throughput

0.611

High

301845

CLPX
ATP-dependent clpX-like chaperone, mitochondrial

2

1

High-throughput

0.574

High

584968

SUMF1
Formylglycine-generating enzyme

2

13

High-throughput

0.574

High

584974

FKB14
Peptidyl-prolyl cis-trans isomerase FKBP14

2

3

High-throughput

0.574

High

532337

CH60
60 kDa heat shock protein, mitochondrial

1

3

High-throughput

0.536

High

584975

UGGG1
UDP-glucose:glycoprotein glucosyltransferase 1

1

1

High-throughput

0.536

High

584972

FBX6
F-box only protein 6

2

10

High-throughput

0.533

High

584950

CAN2
Calpain-2 catalytic subunit

1

0

High-throughput

0.513

High

584970

PAR6B
Partitioning defective 6 homolog beta

1

0

High-throughput

0.513

High

584960

G3BP1
Ras GTPase-activating protein-binding protein 1

1

2

High-throughput

0.489

High

584961

CUL1
Cullin-1

1

2

High-throughput

0.489

High

584977

FBX2
F-box only protein 2

1

10

High-throughput

0.489

High

136818

AGRIN
Agrin [Cleaved into: Agrin N-terminal 110 kDa subunit; Agrin C-terminal 110 kDa subunit; Agrin C-terminal 90 kDa fragment

1

6

High-throughput

0.479

High

440336

FYN
Tyrosine-protein kinase Fyn

1

2

High-throughput

0.479

High

550823

PCNA
Proliferating cell nuclear antigen

1

1

High-throughput

0.479

High

557064

SRC
Proto-oncogene tyrosine-protein kinase Src

1

2

High-throughput

0.479

High

584951

EFNA1
Ephrin-A1

1

2

High-throughput

0.479

High

584956

EFNA4
Ephrin-A4

1

2

High-throughput

0.479

High

584959

GRB2
Growth factor receptor-bound protein 2

1

4

High-throughput

0.479

High

584964

TM11B
Transmembrane protease serine 11B

1

7

High-throughput

0.479

High

536432

HSP7C
Heat shock cognate 71 kDa protein

1

0

High-throughput

0.458

High

584958

RHOA
Transforming protein RhoA

1

0

High-throughput

0.458

High

217788

TGON2
Trans-Golgi network integral membrane protein 2

1

6

High-throughput

0.437

High

362148

ABL1
Tyrosine-protein kinase ABL1

1

2

High-throughput

0.437

High

584949

NCK1
SH2/SH3 adapter protein NCK1

1

3

High-throughput

0.437

High

584953

EPHA2
Ephrin type-A receptor 2

1

2

High-throughput

0.437

High

584954

MECP2
Methyl-CpG-binding protein 2

1

1

High-throughput

0.437

High

584955

EFNA3
Ephrin-A3

1

2

High-throughput

0.437

High

584962

TRI67
Tripartite motif-containing protein 67

1

6

High-throughput

0.437

High

584966

TM192
Transmembrane protein 192

1

1

High-throughput

0.437

High

584973

TMPS4
Transmembrane protease serine 4

1

5

High-throughput

0.437

High

584976

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.437

High

584967

POC5
Centrosomal protein POC5

1

2

High-throughput

0.407

High

584969

ENASE
Cytosolic endo-beta-N-acetylglucosaminidase

2

0

High-throughput

0.328

High

122704

KIF2A
Kinesin-like protein KIF2A

1

0

High-throughput

0.279

Low

341894

CEP43
Centrosomal protein 43

1

0

High-throughput

0.279

Low

336339

SVIL
Supervillin

1

0

High-throughput

0.249

Low

584957

ABCE1
ATP-binding cassette sub-family E member 1

1

0

High-throughput

0.249

Low

584963

ATG9A
Autophagy-related protein 9A

1

0

High-throughput

0.249

Low

584971

CFA74
Cilia- and flagella-associated protein 74

1

0

High-throughput

0.249

Low

584952

HEMH
Ferrochelatase, mitochondrial

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025