Protein: ARSA
Arylsulfatase A (ASA) (EC 3.1.6.8) (Cerebroside-sulfatase) [Cleaved into: Arylsulfatase A component B; Arylsulfatase A component C]

Gene: ARSA
Organism: Homo sapiens
Interactions: 83
UniProt ID: P15289

Gene Ontology (top 5):
GO:0004065 - arylsulfatase activity
GO:0004098 - cerebroside-sulfatase activity
GO:0005509 - calcium ion binding
GO:0005576 - extracellular region
GO:0005764 - lysosome

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

582312

GALNS
N-acetylgalactosamine-6-sulfatase

3

7

High-throughput

0.861

High

582307

ARSA
Arylsulfatase A

1

7

Small-scale

0.710

High

582318

SPHM
N-sulphoglucosamine sulphohydrolase

1

7

High-throughput

0.691

High

582324

UPAR
Urokinase plasminogen activator surface receptor

3

4

High-throughput

0.667

High

582347

TMM25
Transmembrane protein 25

3

2

High-throughput

0.667

High

582349

SUMF1
Formylglycine-generating enzyme

3

13

High-throughput

0.667

High

582351

DNS2B
Deoxyribonuclease-2-beta

2

1

High-throughput

0.628

High

582366

KLK5
Kallikrein-5

2

9

High-throughput

0.628

High

582332

PDIA5
Protein disulfide-isomerase A5

2

5

High-throughput

0.611

High

582333

MESD
LRP chaperone MESD

3

5

High-throughput

0.609

High

582334

PTPRK
Receptor-type tyrosine-protein phosphatase kappa

3

4

High-throughput

0.609

High

351653

SG1D1
Secretoglobin family 1D member 1

3

2

High-throughput

0.604

High

582317

ANX11
Annexin A11

2

0

High-throughput

0.580

High

582313

SYUA
Alpha-synuclein

1

1

Small-scale

0.561

High

257089

CCD22
Coiled-coil domain-containing protein 22

2

3

High-throughput

0.553

High

170646

CLGN
Calmegin

1

9

High-throughput

0.536

High

336185

TNF6B
Tumor necrosis factor receptor superfamily member 6B

1

1

High-throughput

0.536

High

532332

CH60
60 kDa heat shock protein, mitochondrial

1

3

High-throughput

0.536

High

534587

BIP
Endoplasmic reticulum chaperone BiP

1

7

High-throughput

0.536

High

566532

PDIA4
Protein disulfide-isomerase A4

1

3

High-throughput

0.536

High

570645

EDN3
Endothelin-3

1

1

High-throughput

0.536

High

573308

ENPL
Endoplasmin

1

6

High-throughput

0.536

High

582308

CALR
Calreticulin

1

9

High-throughput

0.536

High

582311

AMRP
Alpha-2-macroglobulin receptor-associated protein

1

1

High-throughput

0.536

High

582322

ATS12
A disintegrin and metalloproteinase with thrombospondin motifs 12

1

3

High-throughput

0.536

High

582323

NAAA
N-acylethanolamine-hydrolyzing acid amidase

1

6

High-throughput

0.536

High

582327

SEM3B
Semaphorin-3B

1

1

High-throughput

0.536

High

582328

DNJC3
DnaJ homolog subfamily C member 3

1

5

High-throughput

0.536

High

582331

GAS6
Growth arrest-specific protein 6

1

3

High-throughput

0.536

High

582337

DB135
Beta-defensin 135

1

1

High-throughput

0.536

High

582338

TBB8
Tubulin beta-8 chain

1

2

High-throughput

0.536

High

582340

SUSD4
Sushi domain-containing protein 4

1

2

High-throughput

0.536

High

582355

NAR5
Ecto-ADP-ribosyltransferase 5

1

2

High-throughput

0.536

High

582358

CNPY3
Protein canopy homolog 3

1

2

High-throughput

0.536

High

582360

CNTP3
Contactin-associated protein-like 3

1

6

High-throughput

0.536

High

582365

WNT16
Protein Wnt-16

1

2

High-throughput

0.536

High

582367

INSL5
Insulin-like peptide INSL5

1

4

High-throughput

0.536

High

582314

CETN2
Centrin-2

1

0

High-throughput

0.518

High

582315

PPIC
Peptidyl-prolyl cis-trans isomerase C

1

0

High-throughput

0.518

High

132561

UPK1A
Uroplakin-1a

1

0

High-throughput

0.513

High

327102

NXPH4
Neurexophilin-4

1

0

High-throughput

0.513

High

582319

MANF
Mesencephalic astrocyte-derived neurotrophic factor

1

0

High-throughput

0.513

High

582321

RAB25
Ras-related protein Rab-25

1

0

High-throughput

0.513

High

582339

ERFE
Erythroferrone

1

0

High-throughput

0.513

High

582342

PLGT2
Protein O-glucosyltransferase 2

1

0

High-throughput

0.513

High

168373

NCTR3
Natural cytotoxicity triggering receptor 3

1

2

High-throughput

0.489

High

322577

FBX21
F-box only protein 21

1

6

High-throughput

0.489

High

582344

NFXL1
NF-X1-type zinc finger protein NFXL1

1

8

High-throughput

0.489

High

582357

SH23A
SH2 domain-containing protein 3A

1

4

High-throughput

0.489

High

582363

DPEP2
Dipeptidase 2

1

2

High-throughput

0.489

High

217783

TGON2
Trans-Golgi network integral membrane protein 2

1

6

High-throughput

0.479

High

582330

CUL3
Cullin-3

1

2

High-throughput

0.479

High

582353

PLD4
5'-3' exonuclease PLD4

1

0

High-throughput

0.458

High

582310

KAIN
Kallistatin

1

3

High-throughput

0.445

High

582350

CA054
Uncharacterized protein C1orf54

1

6

High-throughput

0.445

High

582345

TRI67
Tripartite motif-containing protein 67

1

6

High-throughput

0.437

High

582352

NECT2
Nectin-2

1

0

High-throughput

0.426

High

2088

TVA20
T cell receptor alpha variable 20

1

2

High-throughput

0.407

High

582325

SRSF4
Serine/arginine-rich splicing factor 4

1

2

High-throughput

0.407

High

582362

KLK15
Kallikrein-15

1

9

High-throughput

0.407

High

582335

PCH2
Pachytene checkpoint protein 2 homolog

6

0

High-throughput

0.387

High

212830

ZBT43
Zinc finger and BTB domain-containing protein 43

3

0

High-throughput

0.347

High

277080

PROP1
Homeobox protein prophet of Pit-1

2

0

High-throughput

0.316

High

330034

VENTX
Homeobox protein VENTX

2

0

High-throughput

0.316

High

582309

PIT1
Pituitary-specific positive transcription factor 1

2

0

High-throughput

0.316

High

582326

FOXI1
Forkhead box protein I1

2

0

High-throughput

0.316

High

582329

KCC2B
Calcium/calmodulin-dependent protein kinase type II subunit beta

2

0

High-throughput

0.316

High

582336

PKN1
Serine/threonine-protein kinase N1

2

0

High-throughput

0.316

High

582354

EID2B
EP300-interacting inhibitor of differentiation 2B

2

0

High-throughput

0.316

High

582356

RHXF2
Rhox homeobox family member 2

2

0

High-throughput

0.316

High

281172

CDC45
Cell division control protein 45 homolog

1

0

High-throughput

0.279

Low

582320

NDUV3
NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial

1

0

High-throughput

0.279

Low

582346

CTU1
Cytoplasmic tRNA 2-thiolation protein 1

1

0

High-throughput

0.279

Low

582348

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

0

High-throughput

0.279

Low

582359

5NT1A
Cytosolic 5'-nucleotidase 1A

1

0

High-throughput

0.279

Low

582364

FXL12
F-box/LRR-repeat protein 12

1

0

High-throughput

0.279

Low

582341

CV039
Synaptic plasticity regulator PANTS

1

0

High-throughput

0.268

Low

582361

ENKD1
Enkurin domain-containing protein 1

1

0

High-throughput

0.268

Low

582343

CLC4G
C-type lectin domain family 4 member G

1

0

High-throughput

0.265

Low

317438

GFPT2
Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2

1

0

High-throughput

0.249

Low

582316

PPOX
Protoporphyrinogen oxidase

1

0

High-throughput

0.249

Low

431509

AP2A
Transcription factor AP-2-alpha

1

0

High-throughput

0.238

Low


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Last updated: 11Aug2025