HitPredict

Interactor 1: UBE2H (P62256)
Ubiquitin-conjugating enzyme E2 H (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme H) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme H) (UbcH2) (Ubiquitin carrier protein H) (Ubiquitin-conjugating enzyme E2-20K) (Ubiquitin-protein ligase H)
Gene: UBE2H

Interactor 2: TRAIP (Q9BWF2)
E3 ubiquitin-protein ligase TRAIP (EC 2.3.2.27) (RING finger protein 206) (TRAF-interacting protein)
Gene: TRAIP

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	1.00	0.698

Property	Details
Experiments	19549727
Identification Methods	two hybrid, two hybrid array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	UQ_con~zf-RING_2
Common GO terms	GO:0004842 - ubiquitin-protein transferase activity GO:0005634 - nucleus
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 183 Hs			1 469
+	Hs
		919842 UB2D2_HUMAN (7-150): 8.88e-73: 217: 29.73		TRAIP_HUMAN (1-469): 1.32e-114: 346: 100.00
+	Hs
		849430 UB2D1_HUMAN (7-150): 2.2e-72: 216: 32.43		TRAIP_HUMAN (1-469): 1.32e-114: 346: 100.00
+	Hs
		895896 UB2D3_HUMAN (7-150): 5.39e-71: 213: 29.05		TRAIP_HUMAN (1-469): 1.32e-114: 346: 100.00
+	Hs
		551657 UBE2H_HUMAN (1-183): 8.84e-64: 196: 100.00		DESP_HUMAN (35-463): 2.92e-31: 130: 14.06
+	Dm
		715093 UBE2N_DROME (5-152): 6.43e-62: 190: 34.21		Q7K2X1_DROME (7-294): 2.71e-30: 123: 23.65
+	Hs
		787888 UB2D2_HUMAN (7-150): 8.88e-73: 217: 29.73		EPS15_HUMAN (3-170): 2.69e-10: 64.9: 14.53
+	Hs
		787873 UB2D1_HUMAN (7-150): 2.2e-72: 216: 32.43		EPS15_HUMAN (3-170): 2.69e-10: 64.9: 14.53
+	Hs
		787884 UB2D3_HUMAN (7-150): 5.39e-71: 213: 29.05		EPS15_HUMAN (3-170): 2.69e-10: 64.9: 14.53
+	Hs
		908682 UBE2H_HUMAN (1-183): 8.84e-64: 196: 100.00		MRCKA_HUMAN (33-378): 2.7e-14: 77.6: 10.64
+	Hs
		787874 UB2E1_HUMAN (5-150): 3.02e-64: 197: 27.33		EPS15_HUMAN (3-170): 2.69e-10: 64.9: 14.53
+	Hs
		787886 UBE2H_HUMAN (1-183): 8.84e-64: 196: 100.00		EPS15_HUMAN (3-170): 2.69e-10: 64.9: 14.53
+	Hs
		725129 UBE2H_HUMAN (1-183): 8.84e-64: 196: 100.00		MYH10_HUMAN (77-300): 1.02e-09: 63.3: 14.40
+	Hs
		724749 UBE2H_HUMAN (1-183): 8.84e-64: 196: 100.00		MYH9_HUMAN (41-307): 2.24e-09: 62.1: 14.47