HitPredict

Interactor 1: UBE2H (P62256)
Ubiquitin-conjugating enzyme E2 H (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme H) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme H) (UbcH2) (Ubiquitin carrier protein H) (Ubiquitin-conjugating enzyme E2-20K) (Ubiquitin-protein ligase H)
Gene: UBE2H

Interactor 2: SAE1 (Q9UBE0)
SUMO-activating enzyme subunit 1 (Ubiquitin-like 1-activating enzyme E1A) [Cleaved into: SUMO-activating enzyme subunit 1, N-terminally processed]
Gene: SAE1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	38113892
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	ThiF~UQ_con
Common GO terms	GO:0005634 - nucleus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 183 Hs			1 346
+	Hs
		919796 UB2D2_HUMAN (7-150): 8.88e-73: 217: 29.73		UBA3_HUMAN (28-337): 4.67e-82: 258: 17.68
+	Hs
		48107 UB2D2_HUMAN (7-150): 8.88e-73: 217: 29.73		UBA6_HUMAN (17-295): 1.69e-45: 168: 14.48
+	Hs
		48104 UB2D1_HUMAN (7-150): 2.2e-72: 216: 32.43		UBA6_HUMAN (17-295): 1.69e-45: 168: 14.48
+	Hs
		48106 UB2D3_HUMAN (7-150): 5.39e-71: 213: 29.05		UBA6_HUMAN (17-295): 1.69e-45: 168: 14.48
+	Hs
		607190 UB2D4_HUMAN (7-150): 2.75e-73: 218: 31.08		UBA1_HUMAN (4-242): 1.38e-39: 150: 14.73
+	Hs
		607050 UB2D2_HUMAN (7-150): 8.88e-73: 217: 29.73		UBA1_HUMAN (4-242): 1.38e-39: 150: 14.73
+	Hs
		607026 UB2D1_HUMAN (7-150): 2.2e-72: 216: 32.43		UBA1_HUMAN (4-242): 1.38e-39: 150: 14.73
+	Sc
		549788 UBC4_YEAST (1-149): 7.24e-71: 212: 32.03		UBA1_YEAST (16-232): 6.94e-40: 151: 21.61
+	Hs
		607039 UB2D3_HUMAN (7-150): 5.39e-71: 213: 29.05		UBA1_HUMAN (4-242): 1.38e-39: 150: 14.73
+	Sp
		293848 UBC4_SCHPO (7-149): 2.5e-70: 211: 29.25		UBA1_SCHPO (18-236): 6.77e-39: 148: 17.80
+	Hs
		607129 UB2E3_HUMAN (5-150): 1.84e-65: 201: 28.00		UBA1_HUMAN (4-242): 1.38e-39: 150: 14.73
+	Hs
		607136 UB2E2_HUMAN (5-150): 1.61e-65: 201: 27.33		UBA1_HUMAN (4-242): 1.38e-39: 150: 14.73
+	Hs
		607023 UBE2A_HUMAN (4-150): 8.87e-65: 197: 30.46		UBA1_HUMAN (4-242): 1.38e-39: 150: 14.73
+	Hs
		607028 UB2E1_HUMAN (5-150): 3.02e-64: 197: 27.33		UBA1_HUMAN (4-242): 1.38e-39: 150: 14.73
+	Hs
		607047 UBE2H_HUMAN (1-183): 8.84e-64: 196: 100.00		UBA1_HUMAN (4-242): 1.38e-39: 150: 14.73
+	Hs
		607054 UBE2B_HUMAN (4-149): 8e-64: 195: 30.67		UBA1_HUMAN (4-242): 1.38e-39: 150: 14.73
+	Hs
		782203 UB2E1_HUMAN (5-150): 3.02e-64: 197: 27.33		UBA7_HUMAN (17-212): 1.05e-37: 145: 21.50
+	Sp
		293850 UBC8_SCHPO (1-178): 2.41e-62: 192: 55.31		UBA1_SCHPO (18-236): 6.77e-39: 148: 17.80
+	Dm
		715098 UBE2N_DROME (5-152): 6.43e-62: 190: 34.21		Q8T0L3_DROME (17-242): 8.9e-39: 148: 17.50
+	Hs
		908500 UBE2H_HUMAN (1-183): 8.84e-64: 196: 100.00		ULA1_HUMAN (239-343): 2.52e-17: 84.7: 28.18