HitPredict

Interactor 1: 1433E (P62258)
14-3-3 protein epsilon (14-3-3E)
Gene: YWHAE

Interactor 2: TNK1 (Q13470)
Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (CD38 negative kinase 1)
Gene: TNK1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	1.00	0.861

Property	Details
Experiments	25852190, 32707033, 36931259
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, pull down, cross-linking study
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	14-3-3~PK_Tyr_Ser-Thr
Common GO terms	GO:0005737 - cytoplasm GO:0016020 - membrane
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 255 Hs			1 666
+	Hs
		337416 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		ABL1_HUMAN (22-643): 2.23e-124: 397: 21.38
+	Hs
		383724 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		ERBB2_HUMAN (65-631): 7.95e-122: 393: 22.82
+	At
		965327 14332_ARATH (4-255): 1.05e-147: 414: 74.41		PBS1_ARATH (36-471): 3.55e-129: 390: 17.94
+	Hs
		411661 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		LCK_HUMAN (91-392): 1.46e-113: 352: 30.46
+	At
		788521 14333_ARATH (1-253): 3.45e-147: 413: 74.12		PBL9_ARATH (59-404): 2.54e-121: 369: 21.96
+	Hs
		909589 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		ERBB4_HUMAN (89-373): 2.84e-46: 179: 36.68
+	Hs
		338232 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		EGFR_HUMAN (89-373): 4.38e-46: 178: 36.59
+	Hs
		909560 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		FAK2_HUMAN (92-373): 3.64e-45: 175: 36.88