HitPredict

Interactor 1: 1433E (P62258)
14-3-3 protein epsilon (14-3-3E)
Gene: YWHAE

Interactor 2: IKKE (Q14164)
Inhibitor of nuclear factor kappa-B kinase subunit epsilon (I-kappa-B kinase epsilon) (IKK-E) (IKK-epsilon) (IkBKE) (EC 2.7.11.10) (Inducible I kappa-B kinase) (IKK-i)
Gene: IKBKE

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	36931259
Identification Methods	cross-linking study
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0019903 - protein phosphatase binding GO:0031625 - ubiquitin protein ligase binding and 1 others more... GO:0031966 - mitochondrial membrane
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 255 Hs			1 716
+	Hs
		910130 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		TBK1_HUMAN (1-714): 4.2e-162: 486: 48.13
+	Hs
		647862 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		MARK3_HUMAN (9-654): 6.73e-126: 393: 15.46
+	Mm
		910231 1433E_MOUSE (1-255): 4.87e-154: 430: 100.00		MARK3_MOUSE (9-654): 1.51e-125: 393: 16.52
+	Xl
		223344 O57468_XENLA (1-255): 1.7e-152: 426: 96.47		Q804T2_XENLA (9-654): 8.73e-123: 384: 15.79
+	Mm
		910278 1433E_MOUSE (1-255): 4.87e-154: 430: 100.00		TAOK2_MOUSE (2-702): 5.02e-113: 371: 15.97
+	At
		965360 14332_ARATH (4-255): 1.05e-147: 414: 74.41		CIPKC_ARATH (8-465): 1.91e-122: 376: 21.41
+	At
		788672 14333_ARATH (1-253): 3.45e-147: 413: 74.12		CIPKC_ARATH (8-465): 1.91e-122: 376: 21.41
+	At
		1280891 14337_ARATH (2-255): 7.73e-147: 412: 71.21		CIPKC_ARATH (8-465): 1.91e-122: 376: 21.41
+	Hs
		909590 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		KS6A2_HUMAN (6-290): 2.47e-89: 297: 21.95
+	Hs
		883214 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		SIK1_HUMAN (8-267): 1.54e-86: 290: 26.88
+	Hs
		909916 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		MARK4_HUMAN (9-262): 3.68e-86: 289: 28.21
+	Mm
		910308 1433E_MOUSE (1-255): 4.87e-154: 430: 100.00		MARK4_MOUSE (9-262): 3.68e-86: 289: 28.21
+	Mm
		910318 1433E_MOUSE (1-255): 4.87e-154: 430: 100.00		MARK1_MOUSE (9-407): 6.74e-84: 283: 24.69
+	Sc
		419854 BMH2_YEAST (4-242): 1.14e-134: 382: 77.08		SNF1_YEAST (9-487): 5.7e-101: 325: 17.23
+	Sc
		419824 BMH1_YEAST (2-243): 2.43e-134: 381: 75.72		SNF1_YEAST (9-487): 5.7e-101: 325: 17.23
+	Hs
		262252 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		ULK1_HUMAN (2-221): 1.05e-23: 109: 31.72
+	Hs
		909795 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		ULK2_HUMAN (1-221): 7.38e-24: 109: 31.28
+	Hs
		910106 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		MARK1_HUMAN (15-221): 9.47e-22: 102: 34.93
+	Sc
		605967 BMH2_YEAST (4-242): 1.14e-134: 382: 77.08		RAD53_YEAST (12-221): 8.31e-22: 102: 32.09