HitPredict

Interactor 1: 1433E (P62258)
14-3-3 protein epsilon (14-3-3E)
Gene: YWHAE

Interactor 2: SRGP1 (Q7Z6B7)
SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho GTPase-activating protein 13)
Gene: SRGAP1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0007165 - signal transduction
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 255 Hs			1 1085
+	Mm
		910322 1433E_MOUSE (1-255): 4.87e-154: 430: 100.00		SRGP2_MOUSE (1-1085): 0: 695: 65.52
+	Hs
		253335 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		SRGP2_HUMAN (1-1085): 0: 691: 65.49
+	Mm
		910285 1433E_MOUSE (1-255): 4.87e-154: 430: 100.00		SRGP3_MOUSE (1-1085): 0: 685: 67.30
+	Hs
		909873 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		HMHA1_HUMAN (30-844): 4.17e-90: 315: 14.60
+	Hs
		70666 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		MYO9A_HUMAN (75-970): 5.98e-86: 308: 11.93
+	Hs
		64684 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		RHG32_HUMAN (456-1077): 4.76e-84: 302: 17.03
+	Hs
		302638 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		FA13A_HUMAN (494-1085): 4.89e-85: 299: 16.05
+	Mm
		910284 1433E_MOUSE (1-255): 4.87e-154: 430: 100.00		RHG33_MOUSE (346-1043): 2.15e-82: 295: 17.21
+	Hs
		909650 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		RHG21_HUMAN (251-1044): 1.44e-78: 285: 16.73
+	Hs
		910011 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		RGAP1_HUMAN (132-777): 1.31e-81: 281: 13.92
+	Sc
		664801 BMH1_YEAST (2-243): 2.43e-134: 381: 75.72		RGD1_YEAST (67-697): 2.53e-91: 308: 15.61
+	Hs
		506563 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		BCR_HUMAN (494-673): 1.21e-17: 90.9: 30.56