HitPredict

Interactor 1: 1433E (P62258)
14-3-3 protein epsilon (14-3-3E)
Gene: YWHAE

Interactor 2: SNRK (Q9NRH2)
SNF-related serine/threonine-protein kinase (EC 2.7.11.1) (SNF1-related kinase)
Gene: SNRK

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	36931259
Identification Methods	cross-linking study
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0035556 - intracellular signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 255 Hs			1 765
+	Hs
		909730 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		MARK2_HUMAN (2-742): 8.32e-150: 458: 27.38
+	Mm
		910234 1433E_MOUSE (1-255): 4.87e-154: 430: 100.00		MARK2_MOUSE (2-742): 1.61e-147: 452: 27.32
+	Xl
		223345 O57468_XENLA (1-255): 1.7e-152: 426: 96.47		Q8QGV3_XENLA (13-742): 5.46e-148: 453: 27.54
+	Hs
		647862 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		MARK3_HUMAN (13-699): 5.14e-145: 445: 25.47
+	Hs
		909916 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		MARK4_HUMAN (13-652): 5.42e-144: 442: 29.03
+	Mm
		910231 1433E_MOUSE (1-255): 4.87e-154: 430: 100.00		MARK3_MOUSE (13-699): 3.88e-144: 442: 25.47
+	Mm
		910308 1433E_MOUSE (1-255): 4.87e-154: 430: 100.00		MARK4_MOUSE (13-654): 1.23e-143: 441: 28.88
+	Hs
		910013 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		SIK2_HUMAN (1-760): 1.86e-139: 435: 23.53
+	Xl
		223344 O57468_XENLA (1-255): 1.7e-152: 426: 96.47		Q804T2_XENLA (13-678): 5.81e-143: 438: 25.70
+	Hs
		883214 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		SIK1_HUMAN (7-724): 1.83e-139: 431: 25.17
+	Hs
		909786 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		BRSK2_HUMAN (9-484): 1.55e-139: 430: 27.58
+	Mm
		910272 1433E_MOUSE (1-255): 4.87e-154: 430: 100.00		BRSK2_MOUSE (9-484): 1.29e-139: 430: 27.18
+	Hs
		910106 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		MARK1_HUMAN (13-742): 7.59e-138: 427: 25.48
+	Mm
		910318 1433E_MOUSE (1-255): 4.87e-154: 430: 100.00		MARK1_MOUSE (13-742): 1.24e-137: 427: 25.89
+	Hs
		871354 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		AAPK2_HUMAN (1-546): 4.85e-138: 420: 24.73
+	Dm
		90534 1433E_DROME (1-254): 2.95e-146: 411: 82.69		E1JGN0_DROME (13-626): 1.97e-134: 428: 27.97
+	At
		965360 14332_ARATH (4-255): 1.05e-147: 414: 74.41		CIPKC_ARATH (2-362): 5.07e-137: 415: 30.69
+	At
		788672 14333_ARATH (1-253): 3.45e-147: 413: 74.12		CIPKC_ARATH (2-362): 5.07e-137: 415: 30.69
+	At
		1280891 14337_ARATH (2-255): 7.73e-147: 412: 71.21		CIPKC_ARATH (2-362): 5.07e-137: 415: 30.69
+	Hs
		910187 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		SIK3_HUMAN (14-371): 7.29e-72: 258: 39.30