HitPredict

Interactor 1: 1433E (P62258)
14-3-3 protein epsilon (14-3-3E)
Gene: YWHAE

Interactor 2: HDAC9 (Q9UKV0)
Histone deacetylase 9 (HD9) (EC 3.5.1.98) (Histone deacetylase 7B) (HD7) (HD7b) (Histone deacetylase-related protein) (MEF2-interacting transcription repressor MITR)
Gene: HDAC9

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.614

Property	Details
Experiments	20936779, 15166223
Identification Methods	two hybrid, affinity chromatography technology, two hybrid pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0042826 - histone deacetylase binding
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 255 Hs			1 1011
+	Hs
		880661 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		HDAC4_HUMAN (1-1009): 0: 691: 54.67
+	Hs
		910173 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		HDAC5_HUMAN (1-1008): 0: 612: 55.67
+	Mm
		910239 1433E_MOUSE (1-255): 4.87e-154: 430: 100.00		Q3UJF1_MOUSE (1-1008): 0: 609: 54.42
+	Mm
		910352 1433E_MOUSE (1-255): 4.87e-154: 430: 100.00		HDAC5_MOUSE (1-1008): 0: 606: 53.75
+	Hs
		909856 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		HDAC7_HUMAN (75-1008): 1.75e-170: 525: 41.57
+	Mm
		910299 1433E_MOUSE (1-255): 4.87e-154: 430: 100.00		HDAC7_MOUSE (71-1008): 2.68e-155: 485: 41.45
+	Hs
		909530 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		HDAC1_HUMAN (623-1009): 3.2e-140: 430: 23.49
+	Hs
		177251 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		HDAC3_HUMAN (631-1007): 9.3e-131: 404: 22.34
+	At
		817061 14310_ARATH (2-254): 2.39e-137: 388: 71.15		HDA5_ARATH (607-1009): 9.34e-140: 436: 36.65
+	Hs
		910121 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		HDAC6_HUMAN (564-1009): 2e-107: 363: 30.95
+	Sc
		693004 BMH2_YEAST (4-242): 1.14e-134: 382: 77.08		RPD3_YEAST (619-1006): 1.04e-132: 409: 22.67
+	Sc
		664709 BMH1_YEAST (2-243): 2.43e-134: 381: 75.72		RPD3_YEAST (619-1006): 1.04e-132: 409: 22.67