Protein: MBRL
Membralin (Transmembrane protein 259)

Gene: MBRL, TMEM259
Organism: Homo sapiens
Interactions: 90
UniProt ID: Q4ZIN3

Gene Ontology (top 5):
GO:0005783 - endoplasmic reticulum
GO:0005789 - endoplasmic reticulum membrane
GO:0034976 - response to endoplasmic reticulum stress
GO:1904294 - positive regulation of ERAD pathway

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1119215

RN185
E3 ubiquitin-protein ligase RNF185

4

2

Small-scale

0.694

High

1119237

SRPRB
Signal recognition particle receptor subunit beta

3

0

Small-scale

0.628

High

299908

ERLN2
Erlin-2

2

1

Small-scale

0.611

High

1119199

TMUB2
Transmembrane and ubiquitin-like domain-containing protein 2

3

1

Small-scale

0.609

High

654393

CALX
Calnexin

3

0

Small-scale

0.606

High

1119204

TM199
Transmembrane protein 199

2

0

High-throughput

0.602

High

429061

ADRB2
Beta-2 adrenergic receptor

2

1

High-throughput

0.561

High

489429

BCL2
Apoptosis regulator Bcl-2

1

1

High-throughput

0.536

High

714665

CNR2
Cannabinoid receptor 2

1

3

Small-scale

0.536

High

992087

B2CL1
Bcl-2-like protein 1

1

1

High-throughput

0.536

High

1119220

RNF5
E3 ubiquitin-protein ligase RNF5

1

2

High-throughput

0.536

High

872037

AT1B3
Sodium/potassium-transporting ATPase subunit beta-3

2

1

Small-scale

0.533

High

1119223

TMUB1
Transmembrane and ubiquitin-like domain-containing protein 1

2

1

Small-scale

0.533

High

217171

EXTL3
Exostosin-like 3

1

0

High-throughput

0.513

High

302400

CSTN1
Calsyntenin-1

1

0

High-throughput

0.513

High

430701

CD3E
T-cell surface glycoprotein CD3 epsilon chain

1

0

High-throughput

0.513

High

1016591

ASPH
Aspartyl/asparaginyl beta-hydroxylase

1

0

High-throughput

0.513

High

1119193

DIK1A
Divergent protein kinase domain 1A

1

0

High-throughput

0.513

High

1119202

STING
Stimulator of interferon genes protein

1

0

High-throughput

0.513

High

1119210

TLC3A
TLC domain-containing protein 3A

1

0

High-throughput

0.513

High

1119222

EMC6
ER membrane protein complex subunit 6

1

0

High-throughput

0.513

High

237069

PLOD3
Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3 [Includes: Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3

1

0

High-throughput

0.493

High

172017

GP182
G-protein coupled receptor 182

1

2

High-throughput

0.489

High

328335

S1PR4
Sphingosine 1-phosphate receptor 4

1

4

High-throughput

0.489

High

393453

AT1B1
Sodium/potassium-transporting ATPase subunit beta-1

1

1

High-throughput

0.489

High

598739

S1PR1
Sphingosine 1-phosphate receptor 1

1

4

High-throughput

0.489

High

600766

C5AR1
C5a anaphylatoxin chemotactic receptor 1

1

3

High-throughput

0.489

High

626782

PTAFR
Platelet-activating factor receptor

1

3

High-throughput

0.489

High

676805

SSR1
Somatostatin receptor type 1

1

1

High-throughput

0.489

High

686255

GASR
Gastrin/cholecystokinin type B receptor

1

1

High-throughput

0.489

High

782426

P2RY2
P2Y purinoceptor 2

1

4

High-throughput

0.489

High

1119201

LHPL1
LHFPL tetraspan subfamily member 1 protein

1

1

High-throughput

0.489

High

1119209

LHPL5
LHFPL tetraspan subfamily member 5 protein

1

1

High-throughput

0.489

High

1119213

SPSB4
SPRY domain-containing SOCS box protein 4

1

2

High-throughput

0.489

High

1119217

SPSB2
SPRY domain-containing SOCS box protein 2

1

2

High-throughput

0.489

High

1119218

GPR21
Probable G-protein coupled receptor 21

1

2

High-throughput

0.489

High

1119219

CML1
Chemerin-like receptor 1

1

4

High-throughput

0.489

High

1119227

GP173
Probable G-protein coupled receptor 173

1

3

High-throughput

0.489

High

1119228

GPR27
Probable G-protein coupled receptor 27

1

3

High-throughput

0.489

High

266172

ERLN1
Erlin-1

1

1

Small-scale

0.479

High

149651

COPE
Coatomer subunit epsilon

1

0

Small-scale

0.458

High

838870

EMD
Emerin

1

0

Small-scale

0.458

High

1088261

CP51A
Lanosterol 14-alpha demethylase

1

0

Small-scale

0.458

High

1119192

MBRL
Membralin

1

0

Small-scale

0.458

High

1119197

LMBRL
Protein LMBR1L

1

0

High-throughput

0.458

High

1119211

EDEM1
ER degradation-enhancing alpha-mannosidase-like protein 1

1

0

High-throughput

0.458

High

1119232

ZDHC7
Palmitoyltransferase ZDHHC7

1

0

High-throughput

0.458

High

1119198

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.437

High

1119203

S15A3
Solute carrier family 15 member 3

1

1

High-throughput

0.437

High

1119194

STYK1
Tyrosine-protein kinase STYK1

3

0

High-throughput

0.349

High

215784

B3GT2
Beta-1,3-galactosyltransferase 2

3

0

High-throughput

0.347

High

1119236

SIAT9
Lactosylceramide alpha-2,3-sialyltransferase

3

0

High-throughput

0.347

High

1119225

YIPF3
Protein YIPF3

2

0

High-throughput

0.328

High

1119229

TNR19
Tumor necrosis factor receptor superfamily member 19

2

0

High-throughput

0.328

High

217321

TYOBP
TYRO protein tyrosine kinase-binding protein

1

0

High-throughput

0.279

Low

295728

B3GA3
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3

1

0

High-throughput

0.279

Low

328195

SG1D2
Secretoglobin family 1D member 2

1

0

High-throughput

0.279

Low

354847

DQA1
HLA class II histocompatibility antigen, DQ alpha 1 chain

1

0

High-throughput

0.279

Low

361577

APOA2
Apolipoprotein A-II

1

0

High-throughput

0.279

Low

361693

APOC3
Apolipoprotein C-III

1

0

High-throughput

0.279

Low

648024

VATL
V-type proton ATPase 16 kDa proteolipid subunit c

1

0

High-throughput

0.279

Low

874410

APOC4
Apolipoprotein C-IV

1

0

High-throughput

0.279

Low

959227

S25A3
Solute carrier family 25 member 3

1

0

High-throughput

0.279

Low

1119196

TMCO3
Transmembrane and coiled-coil domain-containing protein 3

1

0

High-throughput

0.279

Low

1119200

ANR46
Ankyrin repeat domain-containing protein 46

1

0

High-throughput

0.279

Low

1119205

M4A15
Membrane-spanning 4-domains subfamily A member 15

1

0

High-throughput

0.279

Low

1119207

OR4N2
Olfactory receptor 4N2

1

0

High-throughput

0.279

Low

1119208

OR6T1
Olfactory receptor 6T1

1

0

High-throughput

0.279

Low

1119212

FUCT1
GDP-fucose transporter 1

1

0

High-throughput

0.279

Low

1119214

VOPP1
WW domain binding protein VOPP1

1

0

High-throughput

0.279

Low

1119216

PLPR2
Phospholipid phosphatase-related protein type 2

1

0

High-throughput

0.279

Low

1119221

ABHEA
Protein ABHD14A

1

0

High-throughput

0.279

Low

1119226

GPR88
G protein-coupled receptor 88

1

0

High-throughput

0.279

Low

1119233

P2RX2
P2X purinoceptor 2

1

0

High-throughput

0.279

Low

1119234

TSN16
Tetraspanin-16

1

0

High-throughput

0.279

Low

1119235

TNF18
Tumor necrosis factor ligand superfamily member 18

1

0

High-throughput

0.279

Low

49141

TM223
Transmembrane protein 223

1

0

High-throughput

0.269

Low

205474

TGON2
Trans-Golgi network integral membrane protein 2

1

0

High-throughput

0.249

Low

352633

TNFA
Tumor necrosis factor

1

0

High-throughput

0.249

Low

907687

RS15A
Small ribosomal subunit protein uS8

1

0

Small-scale

0.249

Low

1062422

PAF15
PCNA-associated factor

1

0

Small-scale

0.249

Low

1079745

EREP1
Endosomal transmembrane epsin interactor 1

1

0

High-throughput

0.249

Low

1119155

SIM43
Small integral membrane protein 43

1

0

High-throughput

0.249

Low

1119195

CH074
Uncharacterized protein C8orf74

1

0

High-throughput

0.249

Low

1119206

DAAF3
Dynein axonemal assembly factor 3

1

0

Small-scale

0.249

Low

1119224

TRIM4
E3 ubiquitin-protein ligase TRIM4

1

0

Small-scale

0.249

Low

1119230

T106B
Transmembrane protein 106B

1

0

High-throughput

0.249

Low

1119231

OTULL
Inactive ubiquitin thioesterase OTULINL

1

0

High-throughput

0.249

Low

849859

ARSL
Arylsulfatase L

1

0

High-throughput

0.238

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024