HitPredict

Interactor 1: RUXG (P62308)
Small nuclear ribonucleoprotein G (snRNP-G) (Sm protein G) (Sm-G) (SmG)
Gene: SNRPG

Interactor 2: U1SBP (Q16560)
U11/U12 small nuclear ribonucleoprotein 35 kDa protein (U11/U12 snRNP 35 kDa protein) (U11/U12-35K) (Protein HM-1) (U1 snRNP-binding protein homolog)
Gene: SNRNP35

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000398 - mRNA splicing, via spliceosome GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005689 - U12-type spliceosomal complex GO:0008380 - RNA splicing and 1 others more... GO:0071011 - precatalytic spliceosome
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 76 Hs			1 246
+	Hs
		68425 RUXGL_HUMAN (1-76): 7.68e-29: 99.4: 94.74		U1SBP_HUMAN (1-246): 2.27e-42: 146: 100.00
+	Hs
		442013 RUXG_HUMAN (1-76): 1.78e-29: 100: 100.00		RU17_HUMAN (36-135): 1.04e-38: 141: 45.10
+	Hs
		68395 RUXGL_HUMAN (1-76): 7.68e-29: 99.4: 94.74		RU17_HUMAN (36-135): 1.04e-38: 141: 45.10
+	Dm
		565307 RUXF_DROME (1-74): 1.57e-24: 89: 27.03		RU17_DROME (36-137): 1.6e-41: 148: 46.15
+	Hs
		927963 RSMN_HUMAN (1-70): 1.26e-22: 88.2: 21.25		U1SBP_HUMAN (1-246): 2.27e-42: 146: 100.00
+	Hs
		911852 RUXF_HUMAN (5-73): 4.25e-24: 87.8: 24.64		U1SBP_HUMAN (1-246): 2.27e-42: 146: 100.00
+	Hs
		538978 RSMB_HUMAN (1-70): 6.75e-22: 86.3: 21.25		U1SBP_HUMAN (1-246): 2.27e-42: 146: 100.00
+	Hs
		442037 RSMN_HUMAN (1-70): 1.26e-22: 88.2: 21.25		RU17_HUMAN (36-135): 1.04e-38: 141: 45.10
+	Hs
		442012 RUXF_HUMAN (5-73): 4.25e-24: 87.8: 24.64		RU17_HUMAN (36-135): 1.04e-38: 141: 45.10
+	Sp
		143345 RUXG_SCHPO (1-76): 1.27e-24: 89: 47.37		RU17_SCHPO (23-139): 8.84e-40: 139: 42.02
+	Hs
		441858 RSMB_HUMAN (1-70): 6.75e-22: 86.3: 21.25		RU17_HUMAN (36-135): 1.04e-38: 141: 45.10
+	Sp
		143344 RUXF_SCHPO (5-72): 1.97e-23: 85.9: 23.53		RU17_SCHPO (23-139): 8.84e-40: 139: 42.02
+	Hs
		167659 LSM1_HUMAN (13-74): 7.23e-18: 73.3: 33.85		RU17_HUMAN (36-135): 1.04e-38: 141: 45.10
+	Mm
		646096 RSMB_MOUSE (1-70): 8.68e-22: 85.9: 21.25		TIA1_MOUSE (19-227): 8.45e-21: 91.7: 10.05
+	Sc
		770323 RUXG_YEAST (7-76): 1.94e-22: 83.4: 54.80		RU17_YEAST (36-197): 5.03e-18: 82.9: 30.18
+	Hs
		538845 RSMB_HUMAN (1-70): 6.75e-22: 86.3: 21.25		CSTF2_HUMAN (34-125): 1.25e-15: 77.5: 31.52
+	Sc
		873653 RUXF_YEAST (5-73): 3.07e-21: 80.5: 24.29		RU17_YEAST (36-197): 5.03e-18: 82.9: 30.18