Protein: BRR2
Pre-mRNA-splicing helicase BRR2 (EC 3.6.4.13) (Protein Snu246)

Gene: BRR2
Organism: Saccharomyces cerevisiae S288C
Interactions: 136
UniProt ID: P32639

Gene Ontology (top 5):
GO:0000388 - spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
GO:0000398 - mRNA splicing, via spliceosome
GO:0003676 - nucleic acid binding
GO:0003724 - RNA helicase activity
GO:0005524 - ATP binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

697193

PRP8
Pre-mRNA-splicing factor 8

21

11

Small-scale

0.991

High

589420

PRP2
Pre-mRNA-splicing factor ATP-dependent RNA helicase-like protein PRP2

5

17

Small-scale

0.910

High

554210

PRP16
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16

3

19

Small-scale

0.872

High

697191

BRR2
Pre-mRNA-splicing helicase BRR2

3

17

Small-scale

0.847

High

697196

NCBP1
Nuclear cap-binding protein complex subunit 1

3

7

High-throughput

0.847

High

697265

SP382
Pre-mRNA-splicing factor SPP382

3

0

High-throughput

0.816

High

697231

PRP43
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43

2

20

High-throughput

0.811

High

697234

CWC22
Pre-mRNA-splicing factor CWC22

2

3

High-throughput

0.789

High

697198

SN114
Pre-mRNA-splicing factor SNU114

12

13

Small-scale

0.761

High

697281

SNU66
66 kDa U4/U6.U5 small nuclear ribonucleoprotein component

10

3

Small-scale

0.755

High

586385

PRP6
Pre-mRNA-splicing factor 6

9

20

Small-scale

0.751

High

589069

PRP4
U4/U6 small nuclear ribonucleoprotein PRP4

9

17

Small-scale

0.750

High

697225

LSM8
U6 snRNA-associated Sm-like protein LSm8

10

20

Small-scale

0.750

High

697226

PRP31
Pre-mRNA-processing factor 31

8

8

Small-scale

0.746

High

697250

PRP3
U4/U6 small nuclear ribonucleoprotein PRP3

8

3

Small-scale

0.746

High

697213

RSMB
Small nuclear ribonucleoprotein-associated protein B

8

11

Small-scale

0.745

High

697223

SMD3
Small nuclear ribonucleoprotein Sm D3

7

20

Small-scale

0.742

High

697214

LSM4
U6 snRNA-associated Sm-like protein LSm4

7

9

Small-scale

0.741

High

697241

LSM3
U6 snRNA-associated Sm-like protein LSm3

8

20

Small-scale

0.741

High

697246

SMD1
Small nuclear ribonucleoprotein Sm D1

7

5

Small-scale

0.741

High

697268

DIB1
Spliceosomal protein DIB1

7

2

Small-scale

0.741

High

697202

LSM2
U6 snRNA-associated Sm-like protein LSm2

7

20

Small-scale

0.737

High

697239

LSM7
U6 snRNA-associated Sm-like protein LSm7

6

20

Small-scale

0.724

High

697215

LSM5
U6 snRNA-associated Sm-like protein LSm5

6

2

Small-scale

0.722

High

697264

LSM6
U6 snRNA-associated Sm-like protein LSm6

6

8

Small-scale

0.722

High

697263

SMD2
Small nuclear ribonucleoprotein Sm D2

6

6

Small-scale

0.720

High

697275

CWC2
Pre-mRNA-splicing factor CWC2

5

13

Small-scale

0.718

High

697217

RUXG
Small nuclear ribonucleoprotein G

6

17

Small-scale

0.717

High

697240

RUXF
Small nuclear ribonucleoprotein F

6

8

Small-scale

0.717

High

692272

PRP19
Pre-mRNA-processing factor 19

5

20

Small-scale

0.712

High

697279

SNU23
23 kDa U4/U6.U5 small nuclear ribonucleoprotein component

7

0

Small-scale

0.709

High

697274

RU2A
U2 small nuclear ribonucleoprotein A'

5

14

Small-scale

0.709

High

697252

CEF1
Pre-mRNA-splicing factor CEF1

4

15

Small-scale

0.694

High

697243

PRP38
Pre-mRNA-splicing factor 38

6

0

Small-scale

0.691

High

697256

SYF1
Pre-mRNA-splicing factor SYF1

4

20

Small-scale

0.686

High

697276

CLF1
Pre-mRNA-splicing factor CLF1

4

20

Small-scale

0.686

High

697204

SP381
Pre-mRNA-splicing factor SPP381

5

0

Small-scale

0.682

High

697212

SNU13
13 kDa ribonucleoprotein-associated protein

4

4

Small-scale

0.678

High

697261

SN309
Pre-mRNA-splicing factor SNT309

3

1

High-throughput

0.667

High

697280

PRP46
Pre-mRNA-splicing factor PRP46

3

20

High-throughput

0.667

High

697247

CUS1
Cold sensitive U2 snRNA suppressor 1

3

4

High-throughput

0.664

High

697199

NTR2
Pre-mRNA-splicing factor NTR2

4

0

Small-scale

0.661

High

697278

RUXE
Small nuclear ribonucleoprotein E

4

4

Small-scale

0.659

High

586473

PRP9
Pre-mRNA-splicing factor PRP9

3

1

Small-scale

0.656

High

629364

BUD31
Pre-mRNA-splicing factor BUD31

3

5

Small-scale

0.656

High

692387

PRP21
Pre-mRNA-splicing factor PRP21

3

5

Small-scale

0.656

High

697227

SF3B1
U2 snRNP component HSH155

3

12

Small-scale

0.656

High

697260

RSE1
Pre-mRNA-splicing factor RSE1

3

4

Small-scale

0.656

High

697236

CWC24
Pre-mRNA-splicing factor CWC24

3

4

Small-scale

0.653

High

697273

NCBP2
Nuclear cap-binding protein subunit 2

3

16

High-throughput

0.640

High

697244

RU17
U1 small nuclear ribonucleoprotein 70 kDa homolog

2

17

Small-scale

0.640

High

697208

LIN1
Protein LIN1

2

5

Small-scale

0.628

High

356349

H4
Histone H4

1

9

High-throughput

0.618

High

557959

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

3

Small-scale

0.618

High

616106

PRP28
Pre-mRNA-splicing ATP-dependent RNA helicase PRP28

1

18

Small-scale

0.618

High

622304

PRP22
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP22

1

19

High-throughput

0.618

High

655687

PRP45
Pre-mRNA-processing protein 45

2

10

High-throughput

0.611

High

697203

SLT11
Pre-mRNA-splicing factor SLT11

2

4

High-throughput

0.611

High

697229

CWC23
Pre-mRNA-splicing factor CWC23

2

8

High-throughput

0.611

High

510679

SSB1
Ribosome-associated molecular chaperone SSB1

2

11

High-throughput

0.601

High

697248

SLU7
Pre-mRNA-splicing factor SLU7

2

4

Small-scale

0.600

High

389701

CDC25
Cell division control protein 25

2

0

Small-scale

0.587

High

697251

CWC21
Pre-mRNA-splicing factor CWC21

2

1

Small-scale

0.584

High

697266

URN1
Pre-mRNA-splicing factor URN1

2

0

High-throughput

0.576

High

657723

YJU2
Splicing factor YJU2

2

2

High-throughput

0.571

High

697220

IST3
U2 snRNP component IST3

2

15

High-throughput

0.571

High

598618

ISY1
Pre-mRNA-splicing factor ISY1

2

5

High-throughput

0.558

High

493505

HSP72
Heat shock protein SSA2

2

12

High-throughput

0.552

High

376698

PABP
Polyadenylate-binding protein, cytoplasmic and nuclear

1

11

High-throughput

0.536

High

548522

GCN2
eIF-2-alpha kinase GCN2

1

3

High-throughput

0.536

High

697210

PRP39
Pre-mRNA-processing factor 39

1

20

High-throughput

0.536

High

697219

RFC2
Replication factor C subunit 2

1

4

High-throughput

0.536

High

697271

LUC7
Protein LUC7

1

4

High-throughput

0.536

High

697232

SNU71
U1 small nuclear ribonucleoprotein component SNU71

1

0

High-throughput

0.513

High

697235

NOG2
Nucleolar GTP-binding protein 2

1

9

Small-scale

0.508

High

697282

YD85C
SERF-like protein YDL085C-A

1

0

High-throughput

0.493

High

697230

SEH1
Nucleoporin SEH1

1

20

High-throughput

0.489

High

697197

FAB1
1-phosphatidylinositol 3-phosphate 5-kinase FAB1

1

3

Small-scale

0.481

High

697218

ATAD2
ATPase histone chaperone YTA7

1

4

Small-scale

0.481

High

697245

ACAC
Acetyl-CoA carboxylase

1

1

Small-scale

0.481

High

355409

H2B1
Histone H2B.1

1

7

High-throughput

0.479

High

355835

H2B2
Histone H2B.2

1

7

High-throughput

0.479

High

661698

TF2B
Transcription initiation factor IIB

1

2

High-throughput

0.479

High

688162

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

1

High-throughput

0.479

High

691951

NAB2
Nuclear polyadenylated RNA-binding protein NAB2

1

2

High-throughput

0.479

High

693959

PUB1
Nuclear and cytoplasmic polyadenylated RNA-binding protein PUB1

1

15

High-throughput

0.479

High

696280

PP12
Serine/threonine-protein phosphatase PP1-2

1

4

High-throughput

0.479

High

697205

NTC20
Pre-mRNA-splicing factor NTC20

1

1

High-throughput

0.479

High

697222

PRP17
Pre-mRNA-processing factor 17

1

20

High-throughput

0.479

High

697224

CWC26
Pre-mRNA-splicing factor CWC26

1

2

High-throughput

0.479

High

697233

SYF2
Pre-mRNA-splicing factor SYF2

1

1

High-throughput

0.479

High

697237

CWC25
Pre-mRNA-splicing factor CWC25

1

3

High-throughput

0.479

High

697242

NAM8
Protein NAM8

1

9

High-throughput

0.479

High

697254

CWC15
Pre-mRNA-splicing factor CWC15

1

1

High-throughput

0.479

High

697255

SCC2
Sister chromatid cohesion protein 2

1

3

High-throughput

0.479

High

697262

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

1

High-throughput

0.479

High

697269

RDS3
Pre-mRNA-splicing factor RDS3

1

1

High-throughput

0.479

High

697270

PRP11
Pre-mRNA-splicing factor PRP11

1

5

High-throughput

0.479

High

697272

PML1
Pre-mRNA leakage protein 1

1

2

High-throughput

0.479

High

697283

HSH49
Protein HSH49

1

12

High-throughput

0.479

High

697249

SYH1
SMY2 homolog 2

1

13

Small-scale

0.464

High

420558

SPT2
Protein SPT2

1

0

Small-scale

0.460

High

565266

SPO12
Sporulation-specific protein 12

1

0

Small-scale

0.460

High

697221

MET28
Transcriptional activator of sulfur metabolism MET28

1

0

Small-scale

0.460

High

697257

SPO20
Sporulation-specific protein 20

1

0

Small-scale

0.460

High

566148

EST1
Telomere elongation protein EST1

1

0

High-throughput

0.458

High

696624

RU1A
U1 small nuclear ribonucleoprotein A

1

0

High-throughput

0.458

High

697200

YK21
Uncharacterized protein YKR041W

1

0

High-throughput

0.458

High

366012

HSP82
ATP-dependent molecular chaperone HSP82

1

9

High-throughput

0.445

High

478028

HSP77
Import motor subunit, mitochondrial

1

7

High-throughput

0.445

High

485484

SSBP1
Single-stranded nucleic acid-binding protein

1

9

High-throughput

0.445

High

490698

HSP71
Heat shock protein SSA1

1

12

High-throughput

0.445

High

605725

NPR1
Nitrogen permease reactivator protein

1

7

High-throughput

0.445

High

633064

MAS5
Mitochondrial protein import protein MAS5

1

7

High-throughput

0.445

High

680554

HS104
Heat shock protein 104

1

3

High-throughput

0.445

High

694352

HSP7F
Heat shock protein homolog SSE1

1

20

High-throughput

0.445

High

697194

PRP18
Pre-mRNA-splicing factor 18

1

1

Small-scale

0.445

High

697195

HSP78
Heat shock protein 78, mitochondrial

1

3

High-throughput

0.445

High

697207

SSZ1
Ribosome-associated complex subunit SSZ1

1

4

High-throughput

0.445

High

697216

SSB2
Ribosome-associated molecular chaperone SSB2

1

11

High-throughput

0.445

High

697228

CTF18
Chromosome transmission fidelity protein 18

1

5

High-throughput

0.445

High

697192

SMY2
Protein SMY2

1

2

Small-scale

0.437

High

697253

ACL4
Assembly chaperone of RPL4

1

0

High-throughput

0.426

High

691356

NHP2
H/ACA ribonucleoprotein complex subunit NHP2

1

4

High-throughput

0.407

High

697238

PFD4
Prefoldin subunit 4

1

3

High-throughput

0.407

High

697258

SEC13
Protein transport protein SEC13

1

15

High-throughput

0.407

High

697259

PFD5
Prefoldin subunit 5

1

2

High-throughput

0.407

High

697267

SWA2
Auxilin-like clathrin uncoating factor SWA2

1

7

High-throughput

0.407

High

697277

HSP42
Heat shock protein 42

1

1

High-throughput

0.407

High

697201

SEA4
SEH-associated protein 4

1

0

High-throughput

0.279

Low

697206

AIM4
Altered inheritance of mitochondria protein 4

1

0

High-throughput

0.279

Low

516222

KAR1
Cell division control protein KAR1

1

0

Small-scale

0.251

Low

697211

GIP4
GLC7-interacting protein 4

1

0

Small-scale

0.251

Low

697209

TIM17
Mitochondrial import inner membrane translocase subunit TIM17

1

0

Small-scale

0.249

Low

576220

ERD2
ER lumen protein-retaining receptor

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024