HitPredict

Interactor 1: ERR3 (P62508)
Estrogen-related receptor gamma (ERR gamma-2) (Estrogen receptor-related protein 3) (Nuclear receptor subfamily 3 group B member 3)
Gene: ESRRG

Interactor 2: SRPK1 (Q96SB4)
SRSF protein kinase 1 (EC 2.7.11.1) (SFRS protein kinase 1) (Serine/arginine-rich protein-specific kinase 1) (SR-protein-specific kinase 1)
Gene: SRPK1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.53	0.60	0.569

Property	Details
Experiments	23602568
Identification Methods	enzymatic study, protein kinase assay
Interaction Type	direct interaction, phosphorylation reaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000785 - chromatin GO:0005654 - nucleoplasm
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 458 Hs			1 655
+	Hs
		370259 ESR1_HUMAN (32-457): 2.07e-114: 350: 32.61		SRPK1_HUMAN (1-655): 5.68e-157: 468: 94.64
+	Hs
		369378 ESR1_HUMAN (32-457): 2.07e-114: 350: 32.61		SRPK2_HUMAN (48-655): 9.43e-136: 415: 57.97
+	Hs
		1269424 ESR2_HUMAN (127-458): 1.2e-72: 239: 39.50		SRPK1_HUMAN (1-655): 5.68e-157: 468: 94.64
+	Hs
		942851 ESR2_HUMAN (127-458): 1.2e-72: 239: 39.50		SRPK2_HUMAN (48-655): 9.43e-136: 415: 57.97
+	Hs
		587205 RXRA_HUMAN (30-456): 6.83e-128: 380: 29.85		KS6A6_HUMAN (1-349): 8.64e-77: 261: 15.01
+	Hs
		369662 ESR1_HUMAN (32-457): 2.07e-114: 350: 32.61		KS6A1_HUMAN (1-359): 2.84e-81: 273: 14.32
+	Hs
		369218 ESR1_HUMAN (32-457): 2.07e-114: 350: 32.61		KS6A3_HUMAN (1-353): 1.92e-78: 266: 13.83
+	Hs
		611521 NR4A1_HUMAN (42-454): 8.47e-108: 333: 29.16		KS6A6_HUMAN (1-349): 8.64e-77: 261: 15.01
+	Hs
		369006 ESR1_HUMAN (32-457): 2.07e-114: 350: 32.61		CDK2_HUMAN (414-653): 1.01e-65: 219: 19.43
+	Hs
		370471 ESR1_HUMAN (32-457): 2.07e-114: 350: 32.61		CLK4_HUMAN (436-654): 5.51e-63: 218: 23.89
+	Hs
		369195 ESR1_HUMAN (32-457): 2.07e-114: 350: 32.61		CLK3_HUMAN (484-653): 1.02e-60: 216: 28.65
+	Hs
		369024 ESR1_HUMAN (32-457): 2.07e-114: 350: 32.61		MARK3_HUMAN (409-655): 3.06e-47: 179: 12.65
+	Hs
		369888 ESR1_HUMAN (32-457): 2.07e-114: 350: 32.61		MARK2_HUMAN (409-654): 1.03e-46: 178: 12.70
+	Hs
		834090 ESR2_HUMAN (127-458): 1.2e-72: 239: 39.50		CLK3_HUMAN (484-653): 1.02e-60: 216: 28.65
+	Hs
		647937 ESR2_HUMAN (127-458): 1.2e-72: 239: 39.50		MARK3_HUMAN (409-655): 3.06e-47: 179: 12.65
+	Hs
		1183083 ESR2_HUMAN (127-458): 1.2e-72: 239: 39.50		MARK2_HUMAN (409-654): 1.03e-46: 178: 12.70