HitPredict

Interactor 1: PP2AB (P62714)
Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform (PP2A-beta) (EC 3.1.3.16)
Gene: PPP2CB

Interactor 2: 2A5G (Q13362)
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform (PP2A B subunit isoform B'-gamma) (PP2A B subunit isoform B56-gamma) (PP2A B subunit isoform PR61-gamma) (PP2A B subunit isoform R5-gamma) (Renal carcinoma antigen NY-REN-29)
Gene: PPP2R5C

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.86	1.00	0.932

Property	Details
Experiments	26186194, 27880917, 28514442, 33961781, 19156129
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	B56~Metallophos
Common GO terms	GO:0000159 - protein phosphatase type 2A complex GO:0000775 - chromosome, centromeric region GO:0005634 - nucleus GO:0005829 - cytosol GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 309 Hs			1 524
+	Hs
		930833 PP2AA_HUMAN (1-309): 0: 533: 97.41		2A5G_HUMAN (1-524): 0: 898: 100.00
+	Hs
		890958 PP4C_HUMAN (4-309): 0: 511: 64.50		2A5G_HUMAN (1-524): 0: 898: 100.00
+	Hs
		737787 PP1G_HUMAN (7-306): 0: 510: 46.60		2A5G_HUMAN (1-524): 0: 898: 100.00
+	Hs
		905872 PP1A_HUMAN (5-296): 0: 508: 47.18		2A5G_HUMAN (1-524): 0: 898: 100.00
+	Mm
		915336 PP2AB_MOUSE (1-309): 0: 532: 100.00		Q91V89_MOUSE (17-523): 0: 825: 80.35
+	Mm
		930650 PP2AA_MOUSE (1-309): 0: 532: 97.41		Q91V89_MOUSE (17-523): 0: 825: 80.35
+	Hs
		92474 PP2AA_HUMAN (1-309): 0: 533: 97.41		E9PFR3_HUMAN (23-523): 0: 821: 80.52
+	Hs
		930847 PP2AA_HUMAN (1-309): 0: 533: 97.41		2A5D_HUMAN (23-523): 0: 821: 80.52
+	Hs
		915191 PP2AB_HUMAN (1-309): 0: 532: 100.00		2A5D_HUMAN (23-523): 0: 821: 80.52
+	Hs
		890964 PP4C_HUMAN (4-309): 0: 511: 64.50		2A5D_HUMAN (23-523): 0: 821: 80.52
+	Dm
		619908 PP2A_DROME (1-309): 0: 527: 94.50		Q9VEC6_DROME (25-488): 0: 764: 70.08
+	Dm
		619900 PP2A_DROME (1-309): 0: 527: 94.50		Q9VB23_DROME (22-438): 0: 690: 72.01
+	Hs
		930861 PP2AA_HUMAN (1-309): 0: 533: 97.41		2A5E_HUMAN (21-436): 0: 673: 72.12
+	Hs
		915202 PP2AB_HUMAN (1-309): 0: 532: 100.00		2A5E_HUMAN (21-436): 0: 673: 72.12
+	Hs
		930853 PP2AA_HUMAN (1-309): 0: 533: 97.41		2A5A_HUMAN (23-417): 0: 667: 72.15
+	Hs
		915194 PP2AB_HUMAN (1-309): 0: 532: 100.00		2A5A_HUMAN (23-417): 0: 667: 72.15
+	Hs
		930854 PP2AA_HUMAN (1-309): 0: 533: 97.41		2A5B_HUMAN (18-436): 0: 662: 68.50
+	Hs
		915195 PP2AB_HUMAN (1-309): 0: 532: 100.00		2A5B_HUMAN (18-436): 0: 662: 68.50
+	Sc
		618834 PP2A2_YEAST (9-309): 0: 531: 76.08		2A5D_YEAST (18-438): 0: 625: 54.75
+	Sc
		618770 PP2A1_YEAST (7-309): 0: 519: 74.92		2A5D_YEAST (18-438): 0: 625: 54.75