HitPredict

Interactor 1: ACTA (P62736)
Actin, aortic smooth muscle (EC 3.6.4.-) (Alpha-actin-2) (Cell growth-inhibiting gene 46 protein) [Cleaved into: Actin, aortic smooth muscle, intermediate form]
Gene: ACTA2

Interactor 2: DREB (Q16643)
Drebrin (Developmentally-regulated brain protein)
Gene: DBN1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	1.00	0.861

Property	Details
Experiments	28514442, 33961781, 37071682
Identification Methods	affinity chromatography technology, cross-linking study, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Actin~Cofilin_ADF
Common GO terms	GO:0005737 - cytoplasm GO:0030027 - lamellipodium
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 377 Hs			1 649
+	Hs
		1084964 ACTBL_HUMAN (4-377): 0: 712: 87.97		DREB_HUMAN (1-649): 5.59e-95: 307: 100.00
+	Hs
		891799 ACTB_HUMAN (4-377): 0: 598: 94.12		DREB_HUMAN (1-649): 5.59e-95: 307: 100.00
+	Hs
		929879 ACTG_HUMAN (4-377): 0: 598: 94.39		DREB_HUMAN (1-649): 5.59e-95: 307: 100.00
+	Hs
		932187 ACTC_HUMAN (1-377): 0: 598: 98.41		DREB_HUMAN (1-649): 5.59e-95: 307: 100.00
+	Hs
		892099 ACTB_HUMAN (4-377): 0: 598: 94.12		DBNL_HUMAN (3-464): 1.68e-73: 244: 29.98
+	Hs
		932439 ACTC_HUMAN (1-377): 0: 598: 98.41		DBNL_HUMAN (3-464): 1.68e-73: 244: 29.98
+	Sc
		551386 ACT_YEAST (4-377): 0: 643: 86.63		ABP1_YEAST (4-508): 1.78e-30: 128: 13.51
+	Ce
		501469 ACT2_CAEEL (1-377): 0: 599: 94.43		Q9XUT0_CAEEL (4-564): 1.01e-44: 171: 16.98
+	Hs
		891932 ACTB_HUMAN (4-377): 0: 598: 94.12		CTTB2_HUMAN (131-644): 3.31e-33: 139: 14.55
+	Dm
		950123 ACT6_DROME (1-377): 0: 593: 92.84		TITIN_DROME (173-542): 1.72e-27: 121: 13.80
+	Hs
		203220 ACTC_HUMAN (1-377): 0: 598: 98.41		SYNJ1_HUMAN (103-518): 1.79e-09: 63.3: 9.35
+	Dm
		54871 ACT6_DROME (1-377): 0: 593: 92.84		A1ZA72_DROME (119-642): 1.06e-09: 64.1: 10.13