HitPredict

Interactor 1: ACTA (P62736)
Actin, aortic smooth muscle (EC 3.6.4.-) (Alpha-actin-2) (Cell growth-inhibiting gene 46 protein) [Cleaved into: Actin, aortic smooth muscle, intermediate form]
Gene: ACTA2

Interactor 2: TSC1 (Q92574)
Hamartin (Tuberous sclerosis 1 protein)
Gene: TSC1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.34	0.60	0.457

Property	Details
Experiments	17355907
Identification Methods	two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0030027 - lamellipodium GO:0032991 - protein-containing complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 377 Hs			1 1164
+	Hs
		891934 ACTB_HUMAN (4-377): 0: 598: 94.12		TSC1_HUMAN (1-1164): 0: 725: 100.00
+	Hs
		724859 ACTBL_HUMAN (4-377): 0: 712: 87.97		MYH9_HUMAN (673-1164): 1.25e-23: 111: 12.40
+	Hs
		891760 ACTB_HUMAN (4-377): 0: 598: 94.12		DCTN1_HUMAN (540-1022): 9.26e-59: 223: 16.33
+	Hs
		929862 ACTG_HUMAN (4-377): 0: 598: 94.39		DCTN1_HUMAN (540-1022): 9.26e-59: 223: 16.33
+	Hs
		932151 ACTC_HUMAN (1-377): 0: 598: 98.41		DCTN1_HUMAN (540-1022): 9.26e-59: 223: 16.33
+	Hs
		915383 ACTA_HUMAN (1-377): 0: 596: 100.00		DCTN1_HUMAN (540-1022): 9.26e-59: 223: 16.33
+	Rn
		892228 ACTB_RAT (4-377): 0: 598: 94.12		MYH9_RAT (519-1164): 1.12e-27: 124: 10.00
+	Hs
		891935 ACTB_HUMAN (4-377): 0: 598: 94.12		MY18A_HUMAN (461-1064): 4e-25: 115: 10.31
+	Hs
		929952 ACTG_HUMAN (4-377): 0: 598: 94.39		MY18A_HUMAN (461-1064): 4e-25: 115: 10.31
+	Hs
		932297 ACTC_HUMAN (1-377): 0: 598: 98.41		MY18A_HUMAN (461-1064): 4e-25: 115: 10.31
+	Hs
		933030 ACTS_HUMAN (1-377): 0: 598: 97.88		MY18A_HUMAN (461-1064): 4e-25: 115: 10.31
+	Rn
		92841 ACTB_RAT (4-377): 0: 598: 94.12		CTRO_RAT (337-1025): 8.64e-25: 114: 9.83
+	Hs
		724738 ACTB_HUMAN (4-377): 0: 598: 94.12		MYH9_HUMAN (673-1164): 1.25e-23: 111: 12.40
+	Hs
		724762 ACTG_HUMAN (4-377): 0: 598: 94.39		MYH9_HUMAN (673-1164): 1.25e-23: 111: 12.40
+	Hs
		724766 ACTC_HUMAN (1-377): 0: 598: 98.41		MYH9_HUMAN (673-1164): 1.25e-23: 111: 12.40
+	Hs
		724767 ACTS_HUMAN (1-377): 0: 598: 97.88		MYH9_HUMAN (673-1164): 1.25e-23: 111: 12.40
+	Hs
		148662 ACTC_HUMAN (1-377): 0: 598: 98.41		CTRO_HUMAN (337-991): 3.67e-23: 109: 7.78
+	Mm
		892205 ACTB_MOUSE (4-377): 0: 598: 94.12		MYH9_MOUSE (753-1164): 6.75e-17: 88.7: 9.71
+	Rn
		892236 ACTB_RAT (4-377): 0: 598: 94.12		MYH10_RAT (813-1164): 1.59e-12: 74.5: 10.51
+	Hs
		725136 ACTC_HUMAN (1-377): 0: 598: 98.41		MYH10_HUMAN (687-992): 3.26e-09: 63.6: 20.43