Protein: RHG21
Rho GTPase-activating protein 21 (Rho GTPase-activating protein 10) (Rho-type GTPase-activating protein 21)

Gene: RHG21, ARHGAP21
Organism: Homo sapiens
Interactions: 184
UniProt ID: Q5T5U3

Gene Ontology (top 5):
GO:0000139 - Golgi membrane
GO:0005096 - GTPase activator activity
GO:0005794 - Golgi apparatus
GO:0005829 - cytosol
GO:0005886 - plasma membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1213091

ANLN
Anillin

2

3

High-throughput

0.789

High

962142

RHOA
Transforming protein RhoA

2

20

High-throughput

0.768

High

375594

RASK
GTPase KRas

2

16

High-throughput

0.754

High

978067

RHOB
Rho-related GTP-binding protein RhoB

2

20

High-throughput

0.754

High

1025554

CDK16
Cyclin-dependent kinase 16

2

3

High-throughput

0.737

High

990321

1433Z
14-3-3 protein zeta/delta

5

20

High-throughput

0.714

High

691091

1433T
14-3-3 protein theta

5

20

High-throughput

0.712

High

729913

1433B
14-3-3 protein beta/alpha

5

20

High-throughput

0.712

High

966431

1433G
14-3-3 protein gamma

4

20

High-throughput

0.694

High

1049384

1433F
14-3-3 protein eta

4

20

High-throughput

0.694

High

1091680

MYO1E
Unconventional myosin-Ie

1

5

High-throughput

0.691

High

1213075

MY18A
Unconventional myosin-XVIIIa

1

3

High-throughput

0.691

High

764819

CTNB1
Catenin beta-1

4

9

Small-scale

0.666

High

764362

CTNA1
Catenin alpha-1

3

6

High-throughput

0.633

High

971615

1433E
14-3-3 protein epsilon

2

12

High-throughput

0.621

High

348139

M4K4
Mitogen-activated protein kinase kinase kinase kinase 4

1

10

High-throughput

0.618

High

126640

RHOD
Rho-related GTP-binding protein RhoD

1

20

High-throughput

0.618

High

270816

ROCK2
Rho-associated protein kinase 2

1

2

High-throughput

0.618

High

341076

DIRA3
GTP-binding protein Di-Ras3

1

4

High-throughput

0.618

High

374664

RASH
GTPase HRas

1

11

High-throughput

0.618

High

440109

LCK
Tyrosine-protein kinase Lck

1

20

High-throughput

0.618

High

463571

LYN
Tyrosine-protein kinase Lyn

1

20

High-throughput

0.618

High

581097

RAC2
Ras-related C3 botulinum toxin substrate 2

1

20

High-throughput

0.618

High

594020

NCK1
SH2/SH3 adapter protein NCK1

1

20

High-throughput

0.618

High

597895

FER
Tyrosine-protein kinase Fer

1

20

High-throughput

0.618

High

601322

RHOQ
Rho-related GTP-binding protein RhoQ

1

20

High-throughput

0.618

High

710290

EPHA2
Ephrin type-A receptor 2

1

20

High-throughput

0.618

High

877140

KC1D
Casein kinase I isoform delta

1

14

High-throughput

0.618

High

885806

KC1E
Casein kinase I isoform epsilon

1

14

High-throughput

0.618

High

891189

GSK3A
Glycogen synthase kinase-3 alpha

1

12

High-throughput

0.618

High

891605

GSK3B
Glycogen synthase kinase-3 beta

1

12

High-throughput

0.618

High

920021

PLK1
Serine/threonine-protein kinase PLK1

1

6

High-throughput

0.618

High

936352

AFAD
Afadin

1

20

High-throughput

0.618

High

952884

ACTB
Actin, cytoplasmic 1

1

20

High-throughput

0.618

High

953496

RAC3
Ras-related C3 botulinum toxin substrate 3

1

20

High-throughput

0.618

High

955270

CDC42
Cell division control protein 42 homolog

1

20

High-throughput

0.618

High

956333

RAB2A
Ras-related protein Rab-2A

1

3

High-throughput

0.618

High

958779

ARF3
ADP-ribosylation factor 3

1

8

High-throughput

0.618

High

962763

RND3
Rho-related GTP-binding protein RhoE

1

20

High-throughput

0.618

High

975077

ARF6
ADP-ribosylation factor 6

1

8

High-throughput

0.618

High

988431

RAC1
Ras-related C3 botulinum toxin substrate 1

1

20

High-throughput

0.618

High

1014904

ARF1
ADP-ribosylation factor 1

1

8

Small-scale

0.618

High

1015040

ARF5
ADP-ribosylation factor 5

1

8

High-throughput

0.618

High

1015505

RHOG
Rho-related GTP-binding protein RhoG

1

20

High-throughput

0.618

High

1144945

RAB35
Ras-related protein Rab-35

1

2

High-throughput

0.618

High

1213051

RHG21
Rho GTPase-activating protein 21

1

15

Small-scale

0.618

High

1213072

PARD3
Partitioning defective 3 homolog

1

19

High-throughput

0.618

High

1213085

RHOJ
Rho-related GTP-binding protein RhoJ

1

20

High-throughput

0.618

High

1213088

ECT2
Protein ECT2

1

7

High-throughput

0.618

High

1213089

RHOF
Rho-related GTP-binding protein RhoF

1

20

High-throughput

0.618

High

1213097

ZO2
Tight junction protein 2

1

9

High-throughput

0.618

High

1213103

ALK
ALK tyrosine kinase receptor

1

20

High-throughput

0.618

High

556140

CADH1
Cadherin-1

2

8

High-throughput

0.611

High

1210573

SAPC1
Suppressor APC domain-containing protein 1

3

1

High-throughput

0.609

High

730650

1433S
14-3-3 protein sigma

2

20

High-throughput

0.601

High

1213053

CP135
Centrosomal protein of 135 kDa

2

6

High-throughput

0.584

High

1213105

NINL
Ninein-like protein

2

13

High-throughput

0.584

High

254158

CTND1
Catenin delta-1

2

8

High-throughput

0.571

High

456750

ANXA2
Annexin A2

2

1

High-throughput

0.571

High

1068228

AHNK
Neuroblast differentiation-associated protein AHNAK

2

2

High-throughput

0.571

High

1213082

PKP4
Plakophilin-4

2

8

High-throughput

0.571

High

1213093

MAT2B
Methionine adenosyltransferase 2 subunit beta

2

1

High-throughput

0.571

High

714882

EF1D
Elongation factor 1-delta

1

0

High-throughput

0.554

High

1213102

PNMA2
Paraneoplastic antigen Ma2

2

6

High-throughput

0.549

High

1213055

CAVN1
Caveolae-associated protein 1

2

0

High-throughput

0.547

High

279389

TULP3
Tubby-related protein 3

1

3

High-throughput

0.541

High

340154

PCNT
Pericentrin

1

15

High-throughput

0.541

High

123728

MYO1C
Unconventional myosin-Ic

1

4

High-throughput

0.536

High

347085

BAG2
BAG family molecular chaperone regulator 2

1

3

High-throughput

0.536

High

407636

S100B
Protein S100-B

1

9

High-throughput

0.536

High

637559

FLNA
Filamin-A

1

6

High-throughput

0.536

High

668621

APC
Adenomatous polyposis coli protein

1

3

High-throughput

0.536

High

732621

ARRB2
Beta-arrestin-2

1

3

High-throughput

0.536

High

772843

MYH9
Myosin-9

1

2

High-throughput

0.536

High

862866

IQGA1
Ras GTPase-activating-like protein IQGAP1

1

7

High-throughput

0.536

High

866711

CAZA2
F-actin-capping protein subunit alpha-2

1

5

High-throughput

0.536

High

968333

PP1B
Serine/threonine-protein phosphatase PP1-beta catalytic subunit

1

2

High-throughput

0.536

High

1160652

DREB
Drebrin

1

2

High-throughput

0.536

High

1213064

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

2

High-throughput

0.536

High

1213067

SYNPO
Synaptopodin

1

4

High-throughput

0.536

High

1213079

MYO19
Unconventional myosin-XIX

1

6

High-throughput

0.536

High

1213087

EGLN3
Prolyl hydroxylase EGLN3

1

2

High-throughput

0.536

High

1213092

MYO5C
Unconventional myosin-Vc

1

1

High-throughput

0.536

High

1213099

LIMA1
LIM domain and actin-binding protein 1

1

7

High-throughput

0.536

High

566705

PDIA4
Protein disulfide-isomerase A4

2

3

High-throughput

0.521

High

1213081

PP1RA
Serine/threonine-protein phosphatase 1 regulatory subunit 10

2

2

High-throughput

0.521

High

1213086

PRR36
Proline-rich protein 36

2

5

High-throughput

0.521

High

181121

AXIN1
Axin-1

1

0

High-throughput

0.513

High

464984

SP1
Transcription factor Sp1

1

16

High-throughput

0.512

High

171077

VP26C
Vacuolar protein sorting-associated protein 26C

1

1

High-throughput

0.494

High

634478

LMNB1
Lamin-B1

1

16

High-throughput

0.489

High

682509

S100P
Protein S100-P

1

10

High-throughput

0.489

High

692716

CALL3
Calmodulin-like protein 3

1

6

High-throughput

0.489

High

706157

S10A2
Protein S100-A2

1

10

High-throughput

0.489

High

1213096

FBLN5
Fibulin-5

1

2

High-throughput

0.489

High

172912

XPO1
Exportin-1

1

13

High-throughput

0.479

High

189617

STX7
Syntaxin-7

1

1

High-throughput

0.479

High

218289

TGON2
Trans-Golgi network integral membrane protein 2

1

2

High-throughput

0.479

High

228486

LANC1
Glutathione S-transferase LANCL1

1

1

High-throughput

0.479

High

251597

CCNT1
Cyclin-T1

1

2

High-throughput

0.479

High

299233

FLOT1
Flotillin-1

1

3

High-throughput

0.479

High

324145

CE152
Centrosomal protein of 152 kDa

1

5

High-throughput

0.479

High

366356

PLMN
Plasminogen

1

2

High-throughput

0.479

High

408915

G3P
Glyceraldehyde-3-phosphate dehydrogenase

1

3

High-throughput

0.479

High

437209

K2C8
Keratin, type II cytoskeletal 8

1

2

High-throughput

0.479

High

445002

S10A9
Protein S100-A9

1

10

High-throughput

0.479

High

459626

PROF1
Profilin-1

1

9

High-throughput

0.479

High

540491

LAMP1
Lysosome-associated membrane glycoprotein 1

1

3

High-throughput

0.479

High

582831

EZRI
Ezrin

1

11

High-throughput

0.479

High

604025

CXA1
Gap junction alpha-1 protein

1

2

High-throughput

0.479

High

642918

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

7

High-throughput

0.479

High

657596

GCSP
Glycine dehydrogenase

1

1

High-throughput

0.479

High

683854

MOES
Moesin

1

11

High-throughput

0.479

High

701995

TMOD1
Tropomodulin-1

1

2

High-throughput

0.479

High

724759

METK2
S-adenosylmethionine synthase isoform type-2

1

4

High-throughput

0.479

High

786658

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

1

2

High-throughput

0.479

High

791448

SYUA
Alpha-synuclein

1

4

High-throughput

0.479

High

799195

BRCA1
Breast cancer type 1 susceptibility protein

1

4

High-throughput

0.479

High

833291

PERI
Peripherin

1

10

High-throughput

0.479

High

872412

SOX2
Transcription factor SOX-2

1

5

High-throughput

0.479

High

896551

VASP
Vasodilator-stimulated phosphoprotein

1

5

High-throughput

0.479

High

903952

BAP31
B-cell receptor-associated protein 31

1

2

High-throughput

0.479

High

986471

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

2

High-throughput

0.479

High

1027512

HNRPU
Heterogeneous nuclear ribonucleoprotein U

1

9

High-throughput

0.479

High

1035685

KIF23
Kinesin-like protein KIF23

1

5

High-throughput

0.479

High

1041110

CAV1
Caveolin-1

1

1

High-throughput

0.479

High

1045379

TF65
Transcription factor p65

1

7

High-throughput

0.479

High

1058458

CKAP4
Cytoskeleton-associated protein 4

1

10

High-throughput

0.479

High

1063785

LG3BP
Galectin-3-binding protein

1

5

High-throughput

0.479

High

1091412

ANK3
Ankyrin-3

1

9

High-throughput

0.479

High

1109797

HDAC1
Histone deacetylase 1

1

5

High-throughput

0.479

High

1123665

DCTN1
Dynactin subunit 1

1

7

High-throughput

0.479

High

1141665

EEA1
Early endosome antigen 1

1

8

High-throughput

0.479

High

1152095

MARE1
Microtubule-associated protein RP/EB family member 1

1

5

High-throughput

0.479

High

1156111

ZYX
Zyxin

1

7

High-throughput

0.479

High

1159683

OCLN
Occludin

1

2

High-throughput

0.479

High

1178186

CL16A
Protein CLEC16A

1

1

High-throughput

0.479

High

1203156

ODFP2
Outer dense fiber protein 2

1

4

High-throughput

0.479

High

1213054

RNF43
E3 ubiquitin-protein ligase RNF43

1

3

High-throughput

0.479

High

1213056

FIP1
Pre-mRNA 3'-end-processing factor FIP1

1

3

High-throughput

0.479

High

1213058

CE128
Centrosomal protein of 128 kDa

1

13

High-throughput

0.479

High

1213060

CNTRL
Centriolin

1

6

High-throughput

0.479

High

1213062

NAA40
N-alpha-acetyltransferase 40

1

2

High-throughput

0.479

High

1213063

DDX42
ATP-dependent RNA helicase DDX42

1

4

High-throughput

0.479

High

1213068

NIN
Ninein

1

13

High-throughput

0.479

High

1213070

NECP1
Adaptin ear-binding coat-associated protein 1

1

1

High-throughput

0.479

High

1213073

PPIL4
Peptidyl-prolyl cis-trans isomerase-like 4

1

2

High-throughput

0.479

High

1213084

CHM4B
Charged multivesicular body protein 4b

1

1

High-throughput

0.479

High

1213090

TRI36
E3 ubiquitin-protein ligase TRIM36

1

20

High-throughput

0.479

High

1213095

ANFY1
Rabankyrin-5

1

8

High-throughput

0.479

High

1213098

ZRAN1
Ubiquitin thioesterase ZRANB1

1

7

High-throughput

0.479

High

1213106

TRRAP
Transformation/transcription domain-associated protein

1

1

High-throughput

0.479

High

186294

PMM2
Phosphomannomutase 2

1

0

High-throughput

0.458

High

226063

STX6
Syntaxin-6

1

0

High-throughput

0.458

High

327302

ZFPL1
Zinc finger protein-like 1

1

0

High-throughput

0.458

High

970633

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.458

High

991859

DYLT1
Dynein light chain Tctex-type 1

1

0

High-throughput

0.458

High

1213066

SPICE
Spindle and centriole-associated protein 1

1

0

High-throughput

0.458

High

1213071

FBX22
F-box only protein 22

1

0

High-throughput

0.458

High

1213094

UBP36
Ubiquitin carboxyl-terminal hydrolase 36

1

0

High-throughput

0.458

High

516530

CALM3
Calmodulin-3

1

6

High-throughput

0.445

High

529940

TAU
Microtubule-associated protein tau

1

9

High-throughput

0.445

High

1213080

SYGP1
Ras/Rap GTPase-activating protein SynGAP

1

7

High-throughput

0.445

High

1103080

ZN177
Zinc finger protein 177

1

15

High-throughput

0.439

High

246654

KDM1A
Lysine-specific histone demethylase 1A

1

6

High-throughput

0.437

High

292144

S2512
Electrogenic aspartate/glutamate antiporter SLC25A12, mitochondrial

1

4

High-throughput

0.437

High

298729

ATP5H
ATP synthase peripheral stalk subunit d, mitochondrial

1

1

High-throughput

0.437

High

424416

HMGN1
Non-histone chromosomal protein HMG-14

1

2

High-throughput

0.437

High

1213057

SYNE3
Nesprin-3

1

5

High-throughput

0.437

High

1213061

PABP2
Polyadenylate-binding protein 2

1

7

High-throughput

0.437

High

1213065

PHF6
PHD finger protein 6

1

2

High-throughput

0.437

High

1213069

CE120
Centrosomal protein of 120 kDa

1

11

High-throughput

0.437

High

1213074

PSPC1
Paraspeckle component 1

1

10

High-throughput

0.437

High

1213076

CK052
Uncharacterized protein C11orf52

1

3

High-throughput

0.437

High

1213077

PF21A
PHD finger protein 21A

1

4

High-throughput

0.437

High

1213100

ATIF1
ATPase inhibitor, mitochondrial

1

2

High-throughput

0.437

High

1213101

RCOR1
REST corepressor 1

1

2

High-throughput

0.437

High

1213104

MARE3
Microtubule-associated protein RP/EB family member 3

1

5

High-throughput

0.437

High

1213052

BTBD8
BTB/POZ domain-containing protein 8

1

10

High-throughput

0.407

High

1213059

CR3L2
Cyclic AMP-responsive element-binding protein 3-like protein 2

1

9

High-throughput

0.407

High

915455

HMGA2
High mobility group protein HMGI-C

1

0

High-throughput

0.249

Low

1213078

ENTR1
Endosome-associated-trafficking regulator 1

1

0

High-throughput

0.249

Low

1213083

NSRP1
Nuclear speckle splicing regulatory protein 1

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025