HitPredict

Interactor 1: RHOB (P62745)
Rho-related GTP-binding protein RhoB (Rho cDNA clone 6) (h6)
Gene: RHOB

Interactor 2: BORG5 (Q00587)
Cdc42 effector protein 1 (Binder of Rho GTPases 5) (Serum protein MSE55)
Gene: CDC42EP1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	34079125, 31871319
Identification Methods	proximity labelling technology, affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PBD~Ras
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0005925 - focal adhesion GO:0007266 - Rho protein signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 196 Hs			1 391
+	Hs
		925198 RAC1_HUMAN (1-196): 2.37e-79: 236: 55.10		BORG5_HUMAN (1-391): 1.77e-158: 452: 100.00
+	Hs
		900382 RHOA_HUMAN (1-196): 7.19e-78: 232: 83.67		BORG5_HUMAN (1-391): 1.77e-158: 452: 100.00
+	Hs
		545325 RAC2_HUMAN (1-196): 7.63e-77: 230: 53.57		BORG5_HUMAN (1-391): 1.77e-158: 452: 100.00
+	Hs
		436256 RHOC_HUMAN (1-196): 8.84e-76: 227: 83.16		BORG5_HUMAN (1-391): 1.77e-158: 452: 100.00
+	Hs
		950927 RHOG_HUMAN (1-196): 8.84e-76: 227: 51.53		BORG5_HUMAN (1-391): 1.77e-158: 452: 100.00
+	Hs
		892320 RAC3_HUMAN (1-179): 1.15e-74: 224: 57.54		BORG5_HUMAN (1-391): 1.77e-158: 452: 100.00
+	Hs
		893907 CDC42_HUMAN (1-196): 1.35e-74: 224: 49.49		BORG5_HUMAN (1-391): 1.77e-158: 452: 100.00
+	Hs
		564481 RHOQ_HUMAN (2-195): 6.71e-68: 207: 51.74		BORG5_HUMAN (1-391): 1.77e-158: 452: 100.00
+	Hs
		925610 RAC1_HUMAN (1-196): 2.37e-79: 236: 55.10		BORG4_HUMAN (25-280): 3.94e-67: 218: 30.54
+	Hs
		900891 RHOA_HUMAN (1-196): 7.19e-78: 232: 83.67		BORG4_HUMAN (25-280): 3.94e-67: 218: 30.54
+	Hs
		915970 RHOB_HUMAN (1-196): 7.52e-78: 232: 100.00		BORG4_HUMAN (25-280): 3.94e-67: 218: 30.54
+	Hs
		545611 RAC2_HUMAN (1-196): 7.63e-77: 230: 53.57		BORG4_HUMAN (25-280): 3.94e-67: 218: 30.54
+	Hs
		951333 RHOG_HUMAN (1-196): 8.84e-76: 227: 51.53		BORG4_HUMAN (25-280): 3.94e-67: 218: 30.54
+	Hs
		892591 RAC3_HUMAN (1-179): 1.15e-74: 224: 57.54		BORG4_HUMAN (25-280): 3.94e-67: 218: 30.54
+	Hs
		894420 CDC42_HUMAN (1-196): 1.35e-74: 224: 49.49		BORG4_HUMAN (25-280): 3.94e-67: 218: 30.54
+	Hs
		564682 RHOQ_HUMAN (2-195): 6.71e-68: 207: 51.74		BORG4_HUMAN (25-280): 3.94e-67: 218: 30.54
+	Hs
		150124 CDC42_HUMAN (1-196): 1.35e-74: 224: 49.49		BORG1_HUMAN (33-217): 2.72e-53: 177: 32.09
+	Hs
		894571 CDC42_HUMAN (1-196): 1.35e-74: 224: 49.49		BORG2_HUMAN (33-218): 6.27e-48: 165: 27.85
+	Hs
		150121 RHOQ_HUMAN (2-195): 6.71e-68: 207: 51.74		BORG1_HUMAN (33-217): 2.72e-53: 177: 32.09
+	Hs
		894139 CDC42_HUMAN (1-196): 1.35e-74: 224: 49.49		BORG3_HUMAN (38-67): 9.1e-09: 55.7: 86.67