HitPredict

Interactor 1: RHOB (P62745)
Rho-related GTP-binding protein RhoB (Rho cDNA clone 6) (h6)
Gene: RHOB

Interactor 2: FERM2 (Q96AC1)
Fermitin family homolog 2 (Kindlin-2) (Mitogen-inducible gene 2 protein) (MIG-2) (Pleckstrin homology domain-containing family C member 1) (PH domain-containing family C member 1)
Gene: FERMT2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	34079125, 31871319
Identification Methods	proximity labelling technology, affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	FERM_M~Ras, PH~Ras
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0005925 - focal adhesion GO:0007155 - cell adhesion and 1 others more... GO:0019901 - protein kinase binding
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 196 Hs			1 680
+	Hs
		925505 RAC1_HUMAN (1-196): 2.37e-79: 236: 55.10		FERM2_HUMAN (1-680): 0: 1112: 100.00
+	Hs
		900779 RHOA_HUMAN (1-196): 7.19e-78: 232: 83.67		FERM2_HUMAN (1-680): 0: 1112: 100.00
+	Hs
		545550 RAC2_HUMAN (1-196): 7.63e-77: 230: 53.57		FERM2_HUMAN (1-680): 0: 1112: 100.00
+	Hs
		436448 RHOC_HUMAN (1-196): 8.84e-76: 227: 83.16		FERM2_HUMAN (1-680): 0: 1112: 100.00
+	Hs
		951217 RHOG_HUMAN (1-196): 8.84e-76: 227: 51.53		FERM2_HUMAN (1-680): 0: 1112: 100.00
+	Hs
		892531 RAC3_HUMAN (1-179): 1.15e-74: 224: 57.54		FERM2_HUMAN (1-680): 0: 1112: 100.00
+	Hs
		894293 CDC42_HUMAN (1-196): 1.35e-74: 224: 49.49		FERM2_HUMAN (1-680): 0: 1112: 100.00
+	Hs
		564642 RHOQ_HUMAN (2-195): 6.71e-68: 207: 51.74		FERM2_HUMAN (1-680): 0: 1112: 100.00
+	Hs
		120577 RHOD_HUMAN (7-182): 3.37e-66: 203: 53.98		FERM2_HUMAN (1-680): 0: 1112: 100.00
+	Hs
		545719 RAC2_HUMAN (1-196): 7.63e-77: 230: 53.57		TLN2_HUMAN (485-670): 8.22e-55: 205: 22.55
+	Dm
		114274 RAC1_DROME (1-196): 1.58e-77: 231: 53.06		M9PBW9_DROME (485-667): 5.49e-53: 200: 17.26
+	Dm
		776919 RAC1_DROME (1-196): 1.58e-77: 231: 53.06		Q9VSL8_DROME (485-667): 5.5e-53: 200: 17.26