HitPredict

Interactor 1: RHOB (P62745)
Rho-related GTP-binding protein RhoB (Rho cDNA clone 6) (h6)
Gene: RHOB

Interactor 2: SLK (Q9H2G2)
STE20-like serine/threonine-protein kinase (STE20-like kinase) (hSLK) (EC 2.7.11.1) (CTCL tumor antigen se20-9) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (Serine/threonine-protein kinase 2)
Gene: SLK

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	34079125, 31871319
Identification Methods	proximity labelling technology, affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Pkinase~Ras
Common GO terms	GO:0005829 - cytosol GO:0006915 - apoptotic process GO:0030334 - regulation of cell migration GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 196 Hs			1 1235
+	Rn
		92842 RHOA_RAT (1-196): 3.27e-78: 233: 83.16		CTRO_RAT (8-1230): 9.38e-148: 493: 15.98
+	Hs
		148653 RAC1_HUMAN (1-196): 2.37e-79: 236: 55.10		CTRO_HUMAN (8-1230): 4.15e-145: 486: 15.52
+	Hs
		148632 RHOB_HUMAN (1-196): 7.52e-78: 232: 100.00		CTRO_HUMAN (8-1230): 4.15e-145: 486: 15.52
+	Mm
		823530 RAC1_MOUSE (1-196): 2.37e-79: 236: 55.10		CTRO_MOUSE (8-1230): 4.45e-138: 465: 16.06
+	Mm
		823539 RHOA_MOUSE (1-196): 3.27e-78: 233: 83.16		CTRO_MOUSE (8-1230): 4.45e-138: 465: 16.06
+	Hs
		296408 RAC1_HUMAN (1-196): 2.37e-79: 236: 55.10		STK10_HUMAN (1-1000): 9.75e-115: 383: 32.25
+	Hs
		296406 RHOB_HUMAN (1-196): 7.52e-78: 232: 100.00		STK10_HUMAN (1-1000): 9.75e-115: 383: 32.25
+	Hs
		925245 RAC1_HUMAN (1-196): 2.37e-79: 236: 55.10		PAK2_HUMAN (7-305): 1.42e-110: 358: 36.79
+	Hs
		915646 RHOB_HUMAN (1-196): 7.52e-78: 232: 100.00		PAK2_HUMAN (7-305): 1.42e-110: 358: 36.79
+	Hs
		850632 RAC1_HUMAN (1-196): 2.37e-79: 236: 55.10		KS6A3_HUMAN (22-342): 5.85e-95: 323: 22.49
+	Hs
		925763 RAC1_HUMAN (1-196): 2.37e-79: 236: 55.10		M4K5_HUMAN (29-292): 6.48e-62: 230: 44.74
+	Mm
		925783 RAC1_MOUSE (1-196): 2.37e-79: 236: 55.10		TNIK_MOUSE (29-323): 2.89e-55: 213: 40.59
+	Hs
		916061 RHOB_HUMAN (1-196): 7.52e-78: 232: 100.00		TNIK_HUMAN (29-323): 5.68e-55: 212: 40.59
+	Hs
		925344 RAC1_HUMAN (1-196): 2.37e-79: 236: 55.10		MRCKA_HUMAN (749-1226): 6.27e-47: 187: 15.39
+	Hs
		915741 RHOB_HUMAN (1-196): 7.52e-78: 232: 100.00		MRCKA_HUMAN (749-1226): 6.27e-47: 187: 15.39
+	Hs
		925766 RAC1_HUMAN (1-196): 2.37e-79: 236: 55.10		MRCKB_HUMAN (697-1209): 1.18e-18: 94.6: 12.80
+	Hs
		925253 RAC1_HUMAN (1-196): 2.37e-79: 236: 55.10		ROCK1_HUMAN (796-1223): 6.3e-17: 88.9: 11.01
+	Hs
		915655 RHOB_HUMAN (1-196): 7.52e-78: 232: 100.00		ROCK1_HUMAN (796-1223): 6.3e-17: 88.9: 11.01
+	Hs
		254468 RAC1_HUMAN (1-196): 2.37e-79: 236: 55.10		ROCK2_HUMAN (590-1232): 1.74e-15: 84.3: 10.38
+	Hs
		254467 RHOB_HUMAN (1-196): 7.52e-78: 232: 100.00		ROCK2_HUMAN (590-1232): 1.74e-15: 84.3: 10.38