HitPredict

Interactor 1: H4 (P62805)
Histone H4
Gene: H4C1

Interactor 2: CBX1 (P83916)
Chromobox protein homolog 1 (HP1Hsbeta) (Heterochromatin protein 1 homolog beta) (HP1 beta) (Heterochromatin protein p25) (M31) (Modifier 1 protein) (p25beta)
Gene: CBX1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.60	0.667

Property	Details
Experiments	27248496, 24981860, 21888893
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000781 - chromosome, telomeric region GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006325 - chromatin organization
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 103 Hs			1 185
+	Hs
		917205 H4_HUMAN (1-103): 1.38e-48: 151: 100.00		CBX3_HUMAN (1-177): 2.11e-63: 195: 69.49
+	Mm
		918238 H4_MOUSE (1-103): 1.38e-48: 151: 100.00		CBX1_MOUSE (1-185): 2.21e-62: 193: 100.00
+	Hs
		800335 H4_HUMAN (1-103): 1.38e-48: 151: 100.00		CBX5_HUMAN (1-183): 9.59e-60: 186: 57.45
+	Mm
		918248 H4_MOUSE (1-103): 1.38e-48: 151: 100.00		CBX5_MOUSE (1-183): 7.63e-60: 186: 57.98
+	Hs
		327834 H4_HUMAN (1-103): 1.38e-48: 151: 100.00		CBX7_HUMAN (12-114): 5.3e-30: 112: 27.18
+	Mm
		918268 H4_MOUSE (1-103): 1.38e-48: 151: 100.00		CBX6_MOUSE (12-101): 2.46e-27: 107: 30.00
+	Mm
		918259 H4_MOUSE (1-103): 1.38e-48: 151: 100.00		CBX7_MOUSE (12-106): 5.6e-28: 104: 27.37
+	Hs
		315996 H4_HUMAN (1-103): 1.38e-48: 151: 100.00		CBX6_HUMAN (12-101): 1.25e-25: 103: 30.00
+	Hs
		917274 H4_HUMAN (1-103): 1.38e-48: 151: 100.00		CBX2_HUMAN (10-110): 2.55e-25: 103: 29.70
+	Hs
		918158 H4_HUMAN (1-103): 1.38e-48: 151: 100.00		CDYL_HUMAN (7-120): 2.53e-25: 103: 25.86
+	Hs
		123221 H4_HUMAN (1-103): 1.38e-48: 151: 100.00		CBX4_HUMAN (12-89): 1e-24: 101: 34.62
+	Hs
		917958 H4_HUMAN (1-103): 1.38e-48: 151: 100.00		CBX8_HUMAN (12-88): 1.45e-24: 100: 35.07
+	Hs
		918227 H4_HUMAN (1-103): 1.38e-48: 151: 100.00		CDY2_HUMAN (18-110): 2.53e-23: 97.9: 25.00
+	Dm
		639958 H4_DROME (1-103): 4.51e-48: 150: 99.03		PC_DROME (2-80): 1.9e-14: 72.2: 35.44