HitPredict

Interactor 1: H4 (P62805)
Histone H4
Gene: H4C1

Interactor 2: EZH2 (Q15910)
Histone-lysine N-methyltransferase EZH2 (EC 2.1.1.356) (ENX-1) (Enhancer of zeste homolog 2) (Lysine N-methyltransferase 6)
Gene: EZH2

Species: Homo sapiens

Source: innatedb

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.77	1.00	0.881

Property	Details
Experiments	27248496, 30804502, 24457600, 36517590
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	CENP-T_C~SET
Common GO terms	GO:0000781 - chromosome, telomeric region GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006325 - chromatin organization
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 103 Hs			1 746
+	Hs
		331767 H4_HUMAN (1-103): 1.38e-48: 151: 100.00		NSD2_HUMAN (275-729): 1.99e-91: 314: 16.03
+	Hs
		917762 H4_HUMAN (1-103): 1.38e-48: 151: 100.00		NSD1_HUMAN (275-729): 6.24e-90: 311: 15.82
+	Hs
		917878 H4_HUMAN (1-103): 1.38e-48: 151: 100.00		SETD2_HUMAN (190-732): 2.07e-89: 310: 16.64
+	Sc
		356466 H4_YEAST (18-103): 6.13e-41: 132: 90.70		SET1_YEAST (205-733): 1.13e-84: 292: 16.01
+	Hs
		917944 H4_HUMAN (1-103): 1.38e-48: 151: 100.00		EHMT1_HUMAN (441-732): 1.73e-70: 253: 24.27
+	Hs
		917879 H4_HUMAN (1-103): 1.38e-48: 151: 100.00		NSD3_HUMAN (275-729): 9.41e-70: 251: 14.42
+	Hs
		917760 H4_HUMAN (1-103): 1.38e-48: 151: 100.00		EHMT2_HUMAN (467-732): 1.91e-68: 247: 24.21
+	Sc
		356561 H4_YEAST (18-103): 6.13e-41: 132: 90.70		SET2_YEAST (470-733): 1.22e-59: 216: 25.56
+	Hs
		917145 H4_HUMAN (1-103): 1.38e-48: 151: 100.00		KMT2A_HUMAN (606-733): 6.89e-19: 94.4: 39.54
+	Hs
		165658 H4_HUMAN (1-103): 1.38e-48: 151: 100.00		SET1A_HUMAN (611-732): 3.19e-18: 92: 38.71