Protein: HOSC
Homocitrate synthase, cytosolic isozyme (HCS) (EC 2.3.3.14)

Gene: HOSC, LYS20
Organism: Saccharomyces cerevisiae S288C
Interactions: 113
UniProt ID: P48570

Gene Ontology (top 5):
GO:0004410 - homocitrate synthase activity
GO:0005634 - nucleus
GO:0005739 - mitochondrion
GO:0006281 - DNA repair
GO:0019878 - lysine biosynthetic process via aminoadipic acid

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

819996

HOSM
Homocitrate synthase, mitochondrial

4

13

High-throughput

0.896

High

819971

HOSC
Homocitrate synthase, cytosolic isozyme

2

13

High-throughput

0.791

High

491772

HSP71
Heat shock protein SSA1

4

9

High-throughput

0.666

High

366565

HSP82
ATP-dependent molecular chaperone HSP82

2

8

High-throughput

0.584

High

692560

ZUO1
Zuotin

2

5

Small-scale

0.584

High

797466

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

2

5

High-throughput

0.584

High

511934

SSB1
Ribosome-associated molecular chaperone SSB1

2

10

High-throughput

0.571

High

544058

HSC82
ATP-dependent molecular chaperone HSC82

2

8

High-throughput

0.571

High

754539

SSZ1
Ribosome-associated complex subunit SSZ1

2

1

High-throughput

0.571

High

768877

SSB2
Ribosome-associated molecular chaperone SSB2

2

10

High-throughput

0.552

High

425357

PHO4
Phosphate system positive regulatory protein PHO4

1

1

High-throughput

0.536

High

356580

H4
Histone H4

1

1

Small-scale

0.501

High

627643

NAP1
Nucleosome assembly protein

1

0

High-throughput

0.493

High

733636

T2EB
Transcription initiation factor IIE subunit beta

1

0

High-throughput

0.493

High

746815

UBP14
Ubiquitin carboxyl-terminal hydrolase 14

1

0

High-throughput

0.493

High

751988

GLO3
ADP-ribosylation factor GTPase-activating protein GLO3

1

0

High-throughput

0.493

High

759396

STM1
Suppressor protein STM1

1

0

High-throughput

0.493

High

774553

DPH1
2-(3-amino-3-carboxypropyl)histidine synthase subunit 1

1

0

High-throughput

0.493

High

819973

RL37B
Large ribosomal subunit protein eL37B

1

0

High-throughput

0.493

High

819985

HMO1
High mobility group protein 1

1

0

High-throughput

0.493

High

819997

YRA1
RNA annealing protein YRA1

1

0

High-throughput

0.493

High

820000

ISA2
Iron-sulfur assembly protein 2

1

0

High-throughput

0.493

High

388994

SYTC
Threonine--tRNA ligase, cytoplasmic

1

2

High-throughput

0.479

High

389113

SYDC
Aspartate--tRNA ligase, cytoplasmic

1

2

High-throughput

0.479

High

412804

KAPA
cAMP-dependent protein kinase type 1

1

3

Small-scale

0.479

High

419920

SNF1
Carbon catabolite-derepressing protein kinase

1

1

Small-scale

0.479

High

479034

RL43A
Large ribosomal subunit protein eL43A

1

1

High-throughput

0.479

High

479135

RL43B
Large ribosomal subunit protein eL43B

1

1

High-throughput

0.479

High

546194

SYKC
Lysine--tRNA ligase, cytoplasmic

1

2

High-throughput

0.479

High

558142

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

3

High-throughput

0.479

High

625865

IF2M
Translation initiation factor IF-2, mitochondrial

1

1

High-throughput

0.479

High

628247

SIS1
Protein SIS1

1

6

High-throughput

0.479

High

662715

TF2B
Transcription initiation factor IIB

1

6

High-throughput

0.479

High

688322

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

2

High-throughput

0.479

High

689630

MET4
Transcriptional activator of sulfur metabolism MET4

1

1

High-throughput

0.479

High

701791

YPT7
Ypt/Rab-type GTPase YPT7

1

1

Small-scale

0.479

High

703682

PRS6A
26S proteasome regulatory subunit 6A

1

1

High-throughput

0.479

High

734844

SYYC
Tyrosine--tRNA ligase, cytoplasmic

1

1

High-throughput

0.479

High

742884

GBLP
Small ribosomal subunit protein RACK1

1

3

Small-scale

0.479

High

744054

SYG
Glycine--tRNA ligase 1, mitochondrial

1

3

High-throughput

0.479

High

819978

UBP10
Ubiquitin carboxyl-terminal hydrolase 10

1

2

High-throughput

0.479

High

819983

GIS1
Transcriptional activator/repressor GIS1

1

1

High-throughput

0.479

High

819984

RUVB1
RuvB-like protein 1

1

2

High-throughput

0.479

High

819995

YL11B
Transposon Ty1-LR1 Gag-Pol polyprotein

1

1

High-throughput

0.479

High

819998

RIO1
Serine/threonine-protein kinase RIO1

1

1

High-throughput

0.479

High

407172

RS3
Small ribosomal subunit protein uS3

1

0

High-throughput

0.458

High

425085

SYH
Histidine--tRNA ligase, mitochondrial

1

0

High-throughput

0.458

High

606696

RPC2
DNA-directed RNA polymerase III subunit RPC2

1

0

High-throughput

0.458

High

615284

IF5A1
Eukaryotic translation initiation factor 5A-1

1

0

High-throughput

0.458

High

619492

PSA2
Proteasome subunit alpha type-2

1

0

High-throughput

0.458

High

629250

RBSK
Ribokinase

1

0

High-throughput

0.458

High

730005

RS27A
Small ribosomal subunit protein eS27A

1

0

High-throughput

0.458

High

753421

ECM29
Proteasome component ECM29

1

0

High-throughput

0.458

High

758941

LYS1
Saccharopine dehydrogenase [NAD(+), L-lysine-forming]

1

0

High-throughput

0.458

High

814139

SSN8
RNA polymerase II holoenzyme cyclin-like subunit

1

0

High-throughput

0.458

High

819974

INO80
Chromatin-remodeling ATPase INO80

1

0

Small-scale

0.458

High

819975

SPC98
Spindle pole body component SPC98

1

0

High-throughput

0.458

High

819981

GCN5
Histone acetyltransferase GCN5

1

0

Small-scale

0.458

High

819986

SCC2
Sister chromatid cohesion protein 2

1

0

High-throughput

0.458

High

819987

RPN9
26S proteasome regulatory subunit RPN9

1

0

High-throughput

0.458

High

819991

NEJ1
Non-homologous end-joining protein 1

1

0

Small-scale

0.458

High

819992

TFC6
Transcription factor tau 91 kDa subunit

1

0

High-throughput

0.458

High

820002

RKM4
Ribosomal lysine N-methyltransferase 4

1

0

High-throughput

0.458

High

478343

HSP77
Import motor subunit, mitochondrial

1

5

High-throughput

0.445

High

494392

HSP72
Heat shock protein SSA2

1

9

High-throughput

0.445

High

554689

HSP26
Heat shock protein 26

1

2

High-throughput

0.445

High

560722

BIP
Endoplasmic reticulum chaperone BiP

1

2

High-throughput

0.445

High

633371

MAS5
Mitochondrial protein import protein MAS5

1

2

High-throughput

0.445

High

680846

HS104
Heat shock protein 104

1

6

High-throughput

0.445

High

695056

HSP7F
Heat shock protein homolog SSE1

1

14

High-throughput

0.445

High

696013

HSP79
Heat shock protein homolog SSE2

1

14

High-throughput

0.445

High

705402

HSP78
Heat shock protein 78, mitochondrial

1

6

High-throughput

0.445

High

715819

MDJ1
DnaJ homolog 1, mitochondrial

1

3

High-throughput

0.445

High

761261

CAJ1
Protein CAJ1

1

2

High-throughput

0.445

High

819980

APJ1
J domain-containing protein APJ1

1

2

High-throughput

0.445

High

524382

CAF20
Cap-associated protein CAF20

1

3

High-throughput

0.437

High

700981

SMY2
Protein SMY2

1

2

High-throughput

0.437

High

701503

SC61A
Protein transport protein SEC61

1

2

High-throughput

0.437

High

714898

PEX5
Peroxisomal targeting signal receptor

1

3

High-throughput

0.437

High

752852

SYNC
Asparagine--tRNA ligase, cytoplasmic

1

2

High-throughput

0.437

High

752935

YHI0
Putative proline--tRNA ligase YHR020W

1

2

High-throughput

0.437

High

817277

HLJ1
Protein HLJ1

1

2

High-throughput

0.437

High

819976

PPID
Peptidyl-prolyl cis-trans isomerase CPR6

1

1

High-throughput

0.437

High

792380

TCPH
T-complex protein 1 subunit eta

1

1

High-throughput

0.407

High

819993

SWA2
Auxilin-like clathrin uncoating factor SWA2

1

2

High-throughput

0.407

High

819999

HSP42
Heat shock protein 42

1

2

High-throughput

0.407

High

407554

RS9B
Small ribosomal subunit protein uS4B

1

0

High-throughput

0.269

Low

629434

PUF4
Pumilio homology domain family member 4

1

0

High-throughput

0.269

Low

745598

YBI6
Uncharacterized protein YBL086C

1

0

High-throughput

0.269

Low

784164

RL10
Large ribosomal subunit protein uL16

1

0

High-throughput

0.269

Low

819979

NAT10
RNA cytidine acetyltransferase

1

0

High-throughput

0.269

Low

819989

RRP5
rRNA biogenesis protein RRP5

1

0

High-throughput

0.269

Low

343841

SYMC
Methionine--tRNA ligase, cytoplasmic

1

0

High-throughput

0.249

Low

383235

RL25
Large ribosomal subunit protein uL23

1

0

High-throughput

0.249

Low

406569

RL22A
Large ribosomal subunit protein eL22A

1

0

High-throughput

0.249

Low

413601

RS14A
Small ribosomal subunit protein uS11A

1

0

High-throughput

0.249

Low

472284

RL31A
Large ribosomal subunit protein eL31A

1

0

High-throughput

0.249

Low

593865

IF2A
Eukaryotic translation initiation factor 2 subunit alpha

1

0

High-throughput

0.249

Low

631972

RS2
Small ribosomal subunit protein uS5

1

0

High-throughput

0.249

Low

643680

SYLC
Leucine--tRNA ligase, cytoplasmic

1

0

High-throughput

0.249

Low

645537

RS7A
Small ribosomal subunit protein eS7A

1

0

High-throughput

0.249

Low

732317

PSG1
PMA1 stabilization in the Golgi protein 1 [Cleaved into: PSG1-N'; PSG1-C']

1

0

High-throughput

0.249

Low

762363

LAA1
AP-1 accessory protein LAA1

1

0

High-throughput

0.249

Low

819972

RS12
Small ribosomal subunit protein eS12

1

0

High-throughput

0.249

Low

819977

PDR16
Phosphatidylinositol transfer protein PDR16

1

0

High-throughput

0.249

Low

819982

YMC0
Uncharacterized protein YML020W

1

0

High-throughput

0.249

Low

819990

CYK2
Cytokinesis protein 2

1

0

High-throughput

0.249

Low

819994

ENB1
Siderophore iron transporter ENB1

1

0

High-throughput

0.249

Low

820001

EMC6
ER membrane protein complex subunit 6

1

0

High-throughput

0.249

Low

762146

YM11
Uncharacterized protein YMR124W

1

0

High-throughput

0.232

Low

766525

PFD2
Prefoldin subunit 2

1

0

High-throughput

0.232

Low

819988

HSP31
Glutathione-independent glyoxalase HSP31

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024