Protein: ISW1
ISWI chromatin-remodeling complex ATPase ISW1 (EC 3.6.4.-)

Gene: ISW1
Organism: Saccharomyces cerevisiae S288C
Interactions: 166
UniProt ID: P38144

Gene Ontology (top 5):
GO:0000182 - rDNA binding
GO:0000785 - chromatin
GO:0000976 - transcription cis-regulatory region binding
GO:0001178 - regulation of transcriptional start site selection at RNA polymerase II promoter
GO:0003682 - chromatin binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

794188

IOC3
ISWI one complex protein 3

12

1

Small-scale

0.983

High

382048

H4
Histone H4

6

16

Small-scale

0.937

High

794203

H3
Histone H3

6

20

Small-scale

0.935

High

381079

H2B1
Histone H2B.1

5

20

Small-scale

0.915

High

419707

H2A2
Histone H2A.2

5

20

Small-scale

0.912

High

744289

CHD1
Chromo domain-containing protein 1

4

17

Small-scale

0.892

High

381496

H2B2
Histone H2B.2

4

20

Small-scale

0.875

High

734417

BTAF1
TATA-binding protein-associated factor MOT1

3

16

Small-scale

0.855

High

794233

ISW2
ISWI chromatin-remodeling complex ATPase ISW2

3

17

Small-scale

0.855

High

794247

H2AZ
Histone H2A.Z

3

20

High-throughput

0.817

High

794244

ARP7
Actin-related protein 7

2

20

High-throughput

0.789

High

459079

RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1

2

3

High-throughput

0.759

High

794246

CMR1
DNA damage-binding protein CMR1

2

18

High-throughput

0.754

High

794234

IOC2
ISWI one complex protein 2

6

1

Small-scale

0.733

High

794218

IOC4
ISWI one complex protein 4

5

1

Small-scale

0.714

High

794214

RUVB1
RuvB-like protein 1

1

8

High-throughput

0.691

High

794229

RSC58
Chromatin structure-remodeling complex protein RSC58

4

1

High-throughput

0.687

High

794230

ESC8
Protein ESC8

4

1

High-throughput

0.683

High

794198

ITC1
Imitation switch two complex protein 1

3

17

High-throughput

0.667

High

794223

SGD1
Suppressor of glycerol defect protein 1

1

9

High-throughput

0.665

High

678318

RSC6
Chromatin structure-remodeling complex protein RSC6

3

18

High-throughput

0.662

High

649955

SIN3
Transcriptional regulatory protein SIN3

3

15

High-throughput

0.657

High

794205

RSC4
Chromatin structure-remodeling complex subunit RSC4

3

20

High-throughput

0.657

High

419410

H2A1
Histone H2A.1

1

20

Small-scale

0.647

High

794185

ATAD2
ATPase histone chaperone YTA7

3

7

High-throughput

0.633

High

745579

RSC7
Chromatin structure-remodeling complex subunit RSC7

2

2

High-throughput

0.621

High

794189

RSC8
Chromatin structure-remodeling complex protein RSC8

2

20

High-throughput

0.621

High

794226

RSC2
Chromatin structure-remodeling complex subunit RSC2

2

20

High-throughput

0.621

High

594334

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

3

High-throughput

0.618

High

647087

RPC2
DNA-directed RNA polymerase III subunit RPC2

1

2

High-throughput

0.618

High

743082

STH1
Nuclear protein STH1/NPS1

1

17

High-throughput

0.618

High

792001

GBLP
Small ribosomal subunit protein RACK1

1

18

High-throughput

0.618

High

794236

RRP6
Exosome complex exonuclease RRP6

1

1

Small-scale

0.618

High

794242

DBP10
ATP-dependent RNA helicase DBP10

1

20

High-throughput

0.618

High

547868

NHP6B
Non-histone chromosomal protein 6B

2

20

High-throughput

0.588

High

794195

RFX1
RFX-like DNA-binding protein RFX1

2

6

High-throughput

0.588

High

794212

NHP10
Non-histone protein 10

2

20

High-throughput

0.588

High

794182

SCC4
MAU2 chromatid cohesion factor homolog

2

3

Small-scale

0.584

High

794186

DSN1
Kinetochore-associated protein DSN1

2

3

High-throughput

0.584

High

637209

PWP1
Periodic tryptophan protein 1

1

20

High-throughput

0.575

High

794222

SWR1
Helicase SWR1

1

16

High-throughput

0.575

High

757759

SAS3
Histone acetyltransferase SAS3

2

7

High-throughput

0.571

High

763876

SPT10
Protein SPT10

2

3

High-throughput

0.571

High

794184

RT106
Histone chaperone RTT106

2

2

High-throughput

0.571

High

794190

TAF1
Transcription initiation factor TFIID subunit 1

2

3

High-throughput

0.571

High

794201

APJ1
J domain-containing protein APJ1

2

7

High-throughput

0.571

High

794209

HOS3
Histone deacetylase HOS3

2

20

High-throughput

0.571

High

794220

POB3
FACT complex subunit POB3

2

10

High-throughput

0.571

High

639006

VPS1
Vacuolar protein sorting-associated protein 1

2

3

High-throughput

0.567

High

526488

HSP72
Heat shock protein SSA2

2

18

High-throughput

0.552

High

544589

SSB1
Ribosome-associated molecular chaperone SSB1

2

18

High-throughput

0.552

High

713263

MCM5
Minichromosome maintenance protein 5

2

5

High-throughput

0.552

High

794183

SSB2
Ribosome-associated molecular chaperone SSB2

2

18

High-throughput

0.552

High

522347

MPPB
Mitochondrial-processing peptidase subunit beta

2

1

High-throughput

0.537

High

794206

ABF2
ARS-binding factor 2, mitochondrial

1

20

High-throughput

0.536

High

794215

HMO1
High mobility group protein 1

1

20

High-throughput

0.536

High

794174

NMD2
Nonsense-mediated mRNA decay protein 2

1

0

High-throughput

0.517

High

415218

TOP1
DNA topoisomerase 1

1

7

High-throughput

0.515

High

794227

RSC3
Chromatin structure-remodeling complex protein RSC3

1

0

High-throughput

0.513

High

521117

PRI1
DNA primase small subunit

1

0

High-throughput

0.493

High

564657

STE12
Protein STE12

1

0

High-throughput

0.493

High

794207

LGE1
Transcriptional regulatory protein LGE1

1

0

High-throughput

0.493

High

646025

KIN3
Serine/threonine-protein kinase KIN3

1

5

High-throughput

0.481

High

735615

SMY1
Kinesin-related protein SMY1

1

7

High-throughput

0.481

High

749663

TYE7
Transcription factor TYE7

1

1

High-throughput

0.481

High

755228

NUF2
Kinetochore protein NUF2

1

2

High-throughput

0.481

High

779741

DYHC
Dynein heavy chain, cytoplasmic

1

2

High-throughput

0.481

High

435037

RS3
Small ribosomal subunit protein uS3

1

4

High-throughput

0.479

High

448955

TOP2
DNA topoisomerase 2

1

9

High-throughput

0.479

High

602006

CBF1
Centromere-binding protein 1

1

10

Small-scale

0.479

High

647757

RFA1
Replication factor A protein 1

1

11

Small-scale

0.479

High

670605

SIS1
Protein SIS1

1

5

High-throughput

0.479

High

706882

TF2B
Transcription initiation factor IIB

1

3

High-throughput

0.479

High

709715

BMH1
Protein BMH1

1

1

High-throughput

0.479

High

734945

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

2

High-throughput

0.479

High

739611

SPT16
FACT complex subunit SPT16

1

6

High-throughput

0.479

High

745711

GSP1
GTP-binding nuclear protein GSP1/CNR1

1

11

High-throughput

0.479

High

747812

SMY2
Protein SMY2

1

1

High-throughput

0.479

High

763313

TAF14
Transcription initiation factor TFIID subunit 14

1

3

Small-scale

0.479

High

764059

SPT21
Protein SPT21

1

2

High-throughput

0.479

High

794170

LDB7
Chromatin structure-remodeling complex protein RSC14

1

1

High-throughput

0.479

High

794171

RFC1
Replication factor C subunit 1

1

8

High-throughput

0.479

High

794208

IMA1
Importin subunit alpha

1

20

Small-scale

0.479

High

794210

RSC9
Chromatin structure-remodeling complex subunit RSC9

1

1

High-throughput

0.479

High

794216

SCC2
Sister chromatid cohesion protein 2

1

2

High-throughput

0.479

High

794224

SFH1
Chromatin structure-remodeling complex subunit SFH1

1

10

High-throughput

0.479

High

794231

SGO1
Shugoshin

1

1

High-throughput

0.479

High

794235

YL11B
Transposon Ty1-LR1 Gag-Pol polyprotein

1

1

High-throughput

0.479

High

794237

SCC1
Sister chromatid cohesion protein 1

1

6

High-throughput

0.479

High

794238

RIO1
Serine/threonine-protein kinase RIO1

1

6

High-throughput

0.479

High

794239

SMT3
Ubiquitin-like protein SMT3

1

13

High-throughput

0.479

High

794248

MEX67
mRNA export factor MEX67

1

2

Small-scale

0.479

High

794249

HTL1
High temperature lethal protein 1

1

1

High-throughput

0.479

High

794192

NNF1
Kinetochore-associated protein NNF1

1

0

High-throughput

0.460

High

653792

APN1
Apurinic-apyrimidinic endonuclease 1

1

0

High-throughput

0.458

High

794199

NSA1
Ribosome biogenesis protein NSA1

1

0

High-throughput

0.458

High

794217

LRS4
Monopolin complex subunit LRS4

1

0

Small-scale

0.458

High

794225

TFC6
Transcription factor tau 91 kDa subunit

1

0

High-throughput

0.458

High

392609

HSP82
ATP-dependent molecular chaperone HSP82

1

8

High-throughput

0.445

High

448165

HAP2
Transcriptional activator HAP2

1

3

High-throughput

0.445

High

481594

HSP73
Heat shock protein SSA3

1

18

High-throughput

0.445

High

488949

SWI6
Regulatory protein SWI6

1

11

High-throughput

0.445

High

523708

HSP71
Heat shock protein SSA1

1

18

High-throughput

0.445

High

547789

NHP6A
Non-histone chromosomal protein 6A

1

20

High-throughput

0.445

High

548769

MCM1
Pheromone receptor transcription factor

1

7

High-throughput

0.445

High

645609

AFT1
Iron-regulated transcriptional activator AFT1

1

1

High-throughput

0.445

High

671521

SWI4
Regulatory protein SWI4

1

11

High-throughput

0.445

High

675932

MAS5
Mitochondrial protein import protein MAS5

1

7

High-throughput

0.445

High

684696

RL5
Large ribosomal subunit protein uL18

1

3

High-throughput

0.445

High

736637

ASF1
Histone chaperone ASF1

1

10

High-throughput

0.445

High

741425

HSP7F
Heat shock protein homolog SSE1

1

20

High-throughput

0.445

High

752171

HSP78
Heat shock protein 78, mitochondrial

1

3

High-throughput

0.445

High

752959

IXR1
Intrastrand cross-link recognition protein

1

20

High-throughput

0.445

High

754148

MSN2
Zinc finger protein MSN2

1

12

High-throughput

0.445

High

781734

SET3
SET domain-containing protein 3

1

16

High-throughput

0.445

High

794173

SSZ1
Ribosome-associated complex subunit SSZ1

1

14

High-throughput

0.445

High

794175

SET1
Histone-lysine N-methyltransferase, H3 lysine-4 specific

1

20

High-throughput

0.445

High

794177

CAJ1
Protein CAJ1

1

4

High-throughput

0.445

High

794178

XDJ1
DnaJ protein homolog XDJ1

1

7

High-throughput

0.445

High

794180

MBP1
Transcription factor MBP1

1

12

High-throughput

0.445

High

794181

HSP7E
Heat shock protein SSC3, mitochondrial

1

17

High-throughput

0.445

High

794191

SET2
Histone-lysine N-methyltransferase, H3 lysine-36 specific

1

20

High-throughput

0.445

High

794197

HOS2
Probable histone deacetylase HOS2

1

20

High-throughput

0.445

High

794211

GCN5
Histone acetyltransferase GCN5

1

20

High-throughput

0.445

High

794213

GIS1
Transcriptional activator/repressor GIS1

1

10

High-throughput

0.445

High

794221

RCO1
Transcriptional regulatory protein RCO1

1

20

High-throughput

0.445

High

794228

BRE1
E3 ubiquitin-protein ligase BRE1

1

17

High-throughput

0.445

High

794240

HSP42
Heat shock protein 42

1

1

High-throughput

0.445

High

794245

CAF1A
Chromatin assembly factor 1 subunit A

1

14

High-throughput

0.445

High

753068

NIP80
Protein NIP100

1

13

High-throughput

0.439

High

794176

END3
Actin cytoskeleton-regulatory complex protein END3

1

1

High-throughput

0.439

High

149719

RS9A
Small ribosomal subunit protein uS4A

1

3

High-throughput

0.437

High

383662

RS17A
Small ribosomal subunit protein eS17A

1

3

High-throughput

0.437

High

410082

RL25
Large ribosomal subunit protein uL23

1

3

High-throughput

0.437

High

433596

RL26A
Large ribosomal subunit protein uL24A

1

6

High-throughput

0.437

High

455021

RS19A
Small ribosomal subunit protein eS19A

1

6

High-throughput

0.437

High

503001

RS22A
Small ribosomal subunit protein uS8A

1

5

High-throughput

0.437

High

504174

RL31A
Large ribosomal subunit protein eL31A

1

4

High-throughput

0.437

High

512399

RS6A
Small ribosomal subunit protein eS6A

1

5

High-throughput

0.437

High

512965

RS8A
Small ribosomal subunit protein eS8A

1

3

High-throughput

0.437

High

514602

RS18A
Small ribosomal subunit protein uS13A

1

3

High-throughput

0.437

High

674576

RS2
Small ribosomal subunit protein uS5

1

4

High-throughput

0.437

High

747318

RSSA1
Small ribosomal subunit protein uS2A

1

2

High-throughput

0.437

High

751662

SEC3
Exocyst complex component SEC3

1

18

High-throughput

0.437

High

753326

RS3A1
Small ribosomal subunit protein eS1A

1

4

High-throughput

0.437

High

778284

RS27A
Small ribosomal subunit protein eS27A

1

4

High-throughput

0.437

High

794172

RS20
Small ribosomal subunit protein uS10

1

3

High-throughput

0.437

High

794179

LAA1
AP-1 accessory protein LAA1

1

3

High-throughput

0.437

High

794194

RS12
Small ribosomal subunit protein eS12

1

3

High-throughput

0.437

High

794204

RS15
Small ribosomal subunit protein uS19

1

3

High-throughput

0.437

High

794232

RS10A
Small ribosomal subunit protein eS10A

1

6

High-throughput

0.437

High

653853

HSP12
12 kDa heat shock protein

1

0

High-throughput

0.426

High

738743

CBF3A
Centromere DNA-binding protein complex CBF3 subunit A

1

0

High-throughput

0.426

High

794202

MOT3
Transcriptional activator/repressor MOT3

1

0

High-throughput

0.426

High

394478

EF1A
Elongation factor 1-alpha

1

2

High-throughput

0.407

High

427031

FUR4
Uracil permease

1

1

High-throughput

0.407

High

577110

SEC63
Protein translocation protein SEC63

1

6

High-throughput

0.407

High

740491

UBP4
Ubiquitin carboxyl-terminal hydrolase 4

1

8

High-throughput

0.407

High

794193

PFD3
Prefoldin subunit 3

1

1

High-throughput

0.407

High

794196

CCH1
Calcium-channel protein CCH1

1

2

High-throughput

0.407

High

794243

ERP3
Protein ERP3

1

0

High-throughput

0.251

Low

748358

SC61A
Protein transport protein SEC61

1

0

High-throughput

0.249

Low

794187

UTP10
U3 small nucleolar RNA-associated protein 10

1

0

High-throughput

0.249

Low

794200

YG1I
Uncharacterized membrane protein YGR026W

1

0

High-throughput

0.232

Low

794219

PFD5
Prefoldin subunit 5

1

0

High-throughput

0.232

Low

794241

JID1
J domain-containing protein 1

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025