HitPredict

Interactor 1: H4 (P62805)
Histone H4
Gene: H4C1

Interactor 2: CBP (Q92793)
CREB-binding protein (Histone lysine acetyltransferase CREBBP) (EC 2.3.1.48) (Protein lactyltransferas CREBBP) (EC 2.3.1.-) (Protein-lysine acetyltransferase CREBBP) (EC 2.3.1.-)
Gene: CREBBP

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.94	1.00	0.973

Property	Details
Experiments	14720327, 28680062, 32238831, 11163245, 12665567, 12566391, 10097092, 15005629, 24361270
Identification Methods	enzymatic study, x-ray crystallography, classical fluorescence spectroscopy, nuclear magnetic resonance
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	CENP-T_C~HAT_KAT11
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 103 Hs			1 2442
+	Hs
		917170 H4_HUMAN (1-103): 1.38e-48: 151: 100.00		EP300_HUMAN (1-2426): 0: 874: 55.06
+	Hs
		999008 H4G_HUMAN (1-98): 1.04e-38: 126: 84.69		EP300_HUMAN (1-2426): 0: 874: 55.06
+	Hs
		917657 H4_HUMAN (1-103): 1.38e-48: 151: 100.00		PHIP_HUMAN (1045-1205): 3.22e-45: 183: 30.36
+	Dm
		950390 H4_DROME (1-103): 4.51e-48: 150: 99.03		Q4V5A7_DROME (1059-1356): 3.56e-42: 168: 18.54
+	Zm
		19319 A0A1D6IAU4_MAIZE (1-103): 4.97e-53: 163: 98.06		A0A1D6HCG5_MAIZE (1000-1273): 4.58e-37: 153: 21.66
+	Hs
		170320 H4_HUMAN (1-103): 1.38e-48: 151: 100.00		TIF1A_HUMAN (667-1202): 2.17e-34: 147: 17.97
+	Mm
		918262 H4_MOUSE (1-103): 1.38e-48: 151: 100.00		BRDT_MOUSE (1057-1195): 7.37e-34: 145: 25.90
+	Hs
		631388 H4_HUMAN (1-103): 1.38e-48: 151: 100.00		BRD2_HUMAN (1065-1195): 9.64e-34: 143: 30.53
+	Hs
		917299 H4_HUMAN (1-103): 1.38e-48: 151: 100.00		BRD3_HUMAN (1073-1195): 1.36e-33: 143: 30.89
+	Sp
		448927 H4_SCHPO (18-103): 4.87e-42: 135: 89.54		YK82_SCHPO (698-1194): 1.8e-33: 142: 15.18
+	Sc
		356398 H4_YEAST (18-103): 6.13e-41: 132: 90.70		BDF1_YEAST (1024-1207): 1.45e-32: 139: 21.51
+	Sc
		356752 H4_YEAST (18-103): 6.13e-41: 132: 90.70		BDF2_YEAST (955-1279): 4.05e-26: 118: 14.15
+	Hs
		917517 H4_HUMAN (1-103): 1.38e-48: 151: 100.00		PB1_HUMAN (1040-1275): 1.29e-12: 76: 14.83
+	Hs
		917179 H4_HUMAN (1-103): 1.38e-48: 151: 100.00		BPTF_HUMAN (1831-2314): 7.5e-12: 73.6: 11.09
+	Hs
		918062 H4_HUMAN (1-103): 1.38e-48: 151: 100.00		CHD7_HUMAN (70-467): 2.16e-11: 72.1: 9.68
+	Hs
		917621 H4_HUMAN (1-103): 1.38e-48: 151: 100.00		KMT2C_HUMAN (1945-2437): 8.84e-10: 67.1: 13.89
+	Sc
		356682 H4_YEAST (18-103): 6.13e-41: 132: 90.70		GCN5_YEAST (1110-1192): 5.75e-12: 72.4: 37.35