HitPredict

Interactor 1: RAN (P62826)
GTP-binding nuclear protein Ran (EC 3.6.5.-) (Androgen receptor-associated protein 24) (GTPase Ran) (Ras-like protein TC4) (Ras-related nuclear protein)
Gene: RAN

Interactor 2: IPO4 (Q8TEX9)
Importin-4 (Imp4) (Importin-4b) (Imp4b) (Ran-binding protein 4) (RanBP4)
Gene: IPO4

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.63	1.00	0.799

Property	Details
Experiments	35271311, 27114554
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	IBN_N~Ras
Common GO terms	GO:0000785 - chromatin GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0006606 - protein import into nucleus GO:0016020 - membrane and 1 others more... GO:0032991 - protein-containing complex
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 216 Hs			1 1081
+	Hs
		127238 RAN_HUMAN (1-216): 7.75e-79: 237: 100.00		IPO5_HUMAN (2-1081): 0: 568: 19.98
+	Hs
		236414 RB11A_HUMAN (4-207): 7.68e-78: 234: 25.94		RNBP6_HUMAN (2-1081): 1.39e-168: 527: 19.72
+	Sc
		698818 GSP1_YEAST (1-214): 5.23e-83: 247: 80.56		IMB4_YEAST (1-1079): 2.15e-113: 380: 20.96
+	Sc
		699008 GSP2_YEAST (1-214): 1.18e-80: 241: 79.72		IMB4_YEAST (1-1079): 2.15e-113: 380: 20.96
+	Sc
		687908 GSP1_YEAST (1-214): 5.23e-83: 247: 80.56		IMB3_YEAST (5-1079): 1.04e-109: 369: 17.81
+	Sc
		687909 GSP2_YEAST (1-214): 1.18e-80: 241: 79.72		IMB3_YEAST (5-1079): 1.04e-109: 369: 17.81
+	Hs
		312234 RAN_HUMAN (1-216): 7.75e-79: 237: 100.00		IPO7_HUMAN (1-803): 6.37e-90: 313: 12.32
+	Dm
		1373317 RANL_DROME (1-210): 2.56e-93: 273: 60.48		Q9VRV8_DROME (161-1080): 8.11e-70: 253: 12.49
+	Hs
		155560 RAN_HUMAN (1-216): 7.75e-79: 237: 100.00		TNPO2_HUMAN (199-1080): 9.86e-71: 256: 11.72
+	At
		784992 RAN1_ARATH (1-216): 1.39e-95: 279: 73.52		IMB1_ARATH (257-1080): 2.33e-47: 185: 13.67
+	At
		784999 RAN2_ARATH (1-215): 1.36e-88: 261: 74.77		IMB1_ARATH (257-1080): 2.33e-47: 185: 13.67
+	At
		1210454 RAN3_ARATH (1-215): 9.1e-84: 249: 74.31		IMB1_ARATH (257-1080): 2.33e-47: 185: 13.67
+	Sc
		698945 GSP1_YEAST (1-214): 5.23e-83: 247: 80.56		IMB1_YEAST (1-704): 1.63e-40: 163: 14.54
+	Hs
		919077 RAN_HUMAN (1-216): 7.75e-79: 237: 100.00		IMB1_HUMAN (332-1063): 1.95e-37: 154: 12.69
+	Hs
		919198 RAN_HUMAN (1-216): 7.75e-79: 237: 100.00		TNPO1_HUMAN (514-1074): 1.02e-22: 107: 12.96
+	At
		784988 RAN1_ARATH (1-216): 1.39e-95: 279: 73.52		TNPO1_ARATH (680-1076): 7.3e-09: 62: 14.49