Protein: UTP8
U3 small nucleolar RNA-associated protein 8 (U3 snoRNA-associated protein 8) (U three protein 8) (U3 protein 8 required for transcription) (t-UTP8)

Gene: UTP8
Organism: Saccharomyces cerevisiae S288C
Interactions: 157
UniProt ID: P53276

Gene Ontology (top 5):
GO:0000049 - tRNA binding
GO:0000462 - maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0005730 - nucleolus
GO:0006409 - tRNA export from nucleus
GO:0030490 - maturation of SSU-rRNA

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

919182

UTP4
U3 small nucleolar RNA-associated protein 4

11

1

Small-scale

0.758

High

919159

UTP17
NET1-associated nuclear protein 1

10

3

Small-scale

0.756

High

678431

PWP2
Periodic tryptophan protein 2

7

1

Small-scale

0.745

High

806549

UTP9
U3 small nucleolar RNA-associated protein 9

12

0

Small-scale

0.727

High

844550

UTP10
U3 small nucleolar RNA-associated protein 10

10

0

Small-scale

0.724

High

919164

UTP15
U3 small nucleolar RNA-associated protein 15

8

0

Small-scale

0.720

High

919162

UTP5
U3 small nucleolar RNA-associated protein 5

5

1

Small-scale

0.717

High

919179

NOC4
Nucleolar complex protein 4

7

0

Small-scale

0.712

High

918789

UTP22
U3 small nucleolar RNA-associated protein 22

6

0

Small-scale

0.706

High

865147

MPP10
U3 small nucleolar RNA-associated protein MPP10

6

0

Small-scale

0.699

High

817603

UTP7
U3 small nucleolar RNA-associated protein 7

5

0

Small-scale

0.686

High

919203

NOP58
Nucleolar protein 58

4

1

Small-scale

0.676

High

798275

ENP1
Essential nuclear protein 1

5

0

Small-scale

0.669

High

919208

NOP14
Nucleolar complex protein 14

4

0

Small-scale

0.664

High

919172

UTP21
U3 small nucleolar RNA-associated protein 21

3

2

Small-scale

0.640

High

919189

UTP16
U3 small nucleolar RNA-associated protein 16

3

0

High-throughput

0.638

High

823364

UTP18
U3 small nucleolar RNA-associated protein 18

3

0

Small-scale

0.613

High

919153

NAT10
RNA cytidine acetyltransferase

3

0

Small-scale

0.613

High

919157

UTP6
U3 small nucleolar RNA-associated protein 6

3

0

Small-scale

0.613

High

919163

DHR1
Probable ATP-dependent RNA helicase DHR1

3

0

High-throughput

0.613

High

524664

HSP71
Heat shock protein SSA1

3

2

High-throughput

0.611

High

816165

DPO5
rDNA transcriptional regulator POL5

2

0

High-throughput

0.585

High

825542

UTP25
U3 small nucleolar RNA-associated protein 25

2

0

Small-scale

0.585

High

826197

FAF1
Protein FAF1

2

0

Small-scale

0.585

High

919161

HAS1
ATP-dependent RNA helicase HAS1

2

1

Small-scale

0.584

High

919171

UTP13
U3 small nucleolar RNA-associated protein 13

2

3

Small-scale

0.584

High

919148

UTP8
U3 small nucleolar RNA-associated protein 8

2

0

Small-scale

0.576

High

919167

RRP5
rRNA biogenesis protein RRP5

2

0

High-throughput

0.576

High

915389

MSN5
Protein MSN5

2

2

Small-scale

0.570

High

753009

XPOT
Exportin-T

1

2

Small-scale

0.561

High

673209

RRP7
Ribosomal RNA-processing protein 7

2

0

High-throughput

0.559

High

677501

KRR1
KRR1 small subunit processome component

2

0

High-throughput

0.559

High

763600

UTP20
U3 small nucleolar RNA-associated protein 20

2

0

High-throughput

0.559

High

864483

MTR4
ATP-dependent RNA helicase DOB1

2

0

Small-scale

0.559

High

919152

CSL4
Exosome complex component CSL4

2

0

High-throughput

0.559

High

919155

IMP4
U3 small nucleolar ribonucleoprotein protein IMP4

2

0

High-throughput

0.559

High

919166

UTP14
U3 small nucleolar RNA-associated protein 14

2

0

High-throughput

0.559

High

919191

BMS1
Ribosome biogenesis protein BMS1

2

0

High-throughput

0.559

High

919195

RRP6
Exosome complex exonuclease RRP6

2

0

High-throughput

0.559

High

919205

EFG1P
rRNA-processing protein EFG1

2

0

Small-scale

0.559

High

527269

HSP72
Heat shock protein SSA2

2

2

High-throughput

0.552

High

819359

SSB2
Ribosome-associated molecular chaperone SSB2

2

2

High-throughput

0.549

High

747489

RSSA1
Small ribosomal subunit protein uS2A

2

0

High-throughput

0.547

High

511831

RS24A
Small ribosomal subunit protein eS24A

1

0

High-throughput

0.513

High

637251

PWP1
Periodic tryptophan protein 1

1

0

High-throughput

0.513

High

919173

MRD1
Multiple RNA-binding domain-containing protein 1

1

0

Small-scale

0.513

High

570285

RS17B
Small ribosomal subunit protein eS17B

1

1

High-throughput

0.489

High

645758

HSP74
Heat shock protein SSA4

1

2

High-throughput

0.489

High

682348

SPB4
ATP-dependent rRNA helicase SPB4

1

1

High-throughput

0.479

High

722124

XPO1
Exportin-1

1

2

Small-scale

0.479

High

863115

RRP41
Exosome complex component SKI6

1

2

High-throughput

0.479

High

918876

RRP46
Exosome complex component RRP46

1

2

High-throughput

0.479

High

919170

RRP45
Exosome complex component RRP45

1

2

High-throughput

0.479

High

919197

UTP12
U3 small nucleolar RNA-associated protein 12

1

2

High-throughput

0.479

High

919198

RRP42
Exosome complex component RRP42

1

2

High-throughput

0.479

High

919201

NOP56
Nucleolar protein 56

1

1

High-throughput

0.479

High

844337

ELP2
Elongator complex protein 2

1

1

High-throughput

0.470

High

435247

RS3
Small ribosomal subunit protein uS3

1

0

High-throughput

0.458

High

442027

RS14A
Small ribosomal subunit protein uS11A

1

0

High-throughput

0.458

High

512559

RS6A
Small ribosomal subunit protein eS6A

1

0

High-throughput

0.458

High

513129

RS8A
Small ribosomal subunit protein eS8A

1

0

High-throughput

0.458

High

585322

FBRL
rRNA 2'-O-methyltransferase fibrillarin

1

0

High-throughput

0.458

High

672920

RRP43
Exosome complex component RRP43

1

0

High-throughput

0.458

High

674740

RS2
Small ribosomal subunit protein uS5

1

0

High-throughput

0.458

High

689571

RS7A
Small ribosomal subunit protein eS7A

1

0

High-throughput

0.458

High

747030

IMP3
U3 small nucleolar ribonucleoprotein protein IMP3

1

0

High-throughput

0.458

High

753492

RS3A1
Small ribosomal subunit protein eS1A

1

0

High-throughput

0.458

High

754312

DCA13
Protein SOF1

1

0

High-throughput

0.458

High

758392

UTP11
U3 small nucleolar RNA-associated protein 11

1

0

High-throughput

0.458

High

778449

RS27A
Small ribosomal subunit protein eS27A

1

0

High-throughput

0.458

High

782083

RL1D1
Ribosome biogenesis protein UTP30

1

0

High-throughput

0.458

High

802884

DBP8
ATP-dependent RNA helicase DBP8

1

0

High-throughput

0.458

High

804731

RRP4
Exosome complex component RRP4

1

0

High-throughput

0.458

High

804943

LRP1
Exosome complex protein LRP1

1

0

High-throughput

0.458

High

808290

RRP8
25S rRNA

1

0

High-throughput

0.458

High

818324

LCP5
U3 small nucleolar ribonucleoprotein protein LCP5

1

0

High-throughput

0.458

High

825066

RRT14
Regulator of rDNA transcription protein 14

1

0

High-throughput

0.458

High

852584

ROK1
ATP-dependent RNA helicase ROK1

1

0

High-throughput

0.458

High

864939

NOP9
Nucleolar protein 9

1

0

Small-scale

0.458

High

871034

NOL10
Ribosome biogenesis protein ENP2

1

0

High-throughput

0.458

High

871110

MTR3
Exosome complex component MTR3

1

0

High-throughput

0.458

High

874436

RS12
Small ribosomal subunit protein eS12

1

0

High-throughput

0.458

High

918927

PESC
Pescadillo homolog

1

0

High-throughput

0.458

High

919151

ESF2
Pre-rRNA-processing protein ESF2

1

0

High-throughput

0.458

High

919158

NU116
Nucleoporin NUP116/NSP116

1

0

Small-scale

0.458

High

919160

TOM1
E3 ubiquitin-protein ligase TOM1

1

0

High-throughput

0.458

High

919168

FCF1
rRNA-processing protein FCF1

1

0

High-throughput

0.458

High

919174

SGD1
Suppressor of glycerol defect protein 1

1

0

High-throughput

0.458

High

919176

NEP1
Ribosomal RNA small subunit methyltransferase NEP1

1

0

High-throughput

0.458

High

919177

ESF1
Pre-rRNA-processing protein ESF1

1

0

High-throughput

0.458

High

919178

RRP9
Ribosomal RNA-processing protein 9

1

0

High-throughput

0.458

High

919180

BFR2
Protein BFR2

1

0

High-throughput

0.458

High

919184

CMS1
Protein CMS1

1

0

High-throughput

0.458

High

919185

RCL1
rRNA processing protein RCL1

1

0

High-throughput

0.458

High

919186

RRP44
Exosome complex exonuclease DIS3

1

0

High-throughput

0.458

High

919187

RRP40
Exosome complex component RRP40

1

0

High-throughput

0.458

High

919192

FCF2
rRNA-processing protein FCF2

1

0

High-throughput

0.458

High

919193

SAS10
Something about silencing protein 10

1

0

High-throughput

0.458

High

919200

DBP10
ATP-dependent RNA helicase DBP10

1

0

High-throughput

0.458

High

919202

RRP36
rRNA biogenesis protein RRP36

1

0

High-throughput

0.458

High

919204

RRP12
Ribosomal RNA-processing protein 12

1

0

High-throughput

0.458

High

919209

PNO1
Pre-rRNA-processing protein PNO1

1

0

High-throughput

0.458

High

383809

RS17A
Small ribosomal subunit protein eS17A

1

1

High-throughput

0.437

High

430892

ERF3
Eukaryotic peptide chain release factor GTP-binding subunit

1

1

Small-scale

0.437

High

503155

RS22A
Small ribosomal subunit protein uS8A

1

1

High-throughput

0.437

High

919154

APJ1
J domain-containing protein APJ1

1

1

High-throughput

0.437

High

919207

RS22B
Small ribosomal subunit protein uS8B

1

1

High-throughput

0.437

High

394764

EF1A
Elongation factor 1-alpha

1

0

High-throughput

0.426

High

545698

SSB1
Ribosome-associated molecular chaperone SSB1

1

2

High-throughput

0.407

High

676202

MAS5
Mitochondrial protein import protein MAS5

1

1

High-throughput

0.407

High

727204

HS104
Heat shock protein 104

1

1

High-throughput

0.407

High

742907

HSP79
Heat shock protein homolog SSE2

1

3

High-throughput

0.407

High

752549

HSP78
Heat shock protein 78, mitochondrial

1

1

High-throughput

0.407

High

804328

SSZ1
Ribosome-associated complex subunit SSZ1

1

1

High-throughput

0.407

High

745822

GSP1
GTP-binding nuclear protein GSP1/CNR1

2

0

Small-scale

0.325

High

783493

SYYC
Tyrosine--tRNA ligase, cytoplasmic

1

0

Small-scale

0.299

High

636954

CCA1
CCA tRNA nucleotidyltransferase, mitochondrial

1

0

Small-scale

0.292

High

919150

BRE5
UBP3-associated protein BRE5

1

0

High-throughput

0.279

Low

919206

TFB5
General transcription and DNA repair factor IIH subunit TFB5

1

0

Small-scale

0.279

Low

627859

PRP4
U4/U6 small nuclear ribonucleoprotein PRP4

1

0

High-throughput

0.269

Low

919196

YRA1
RNA annealing protein YRA1

1

0

High-throughput

0.269

Low

509661

UBI4P
Polyubiquitin [Cleaved into: Ubiquitin]

1

0

High-throughput

0.261

Low

433757

RL26A
Large ribosomal subunit protein uL24A

1

0

High-throughput

0.249

Low

455174

RS19A
Small ribosomal subunit protein eS19A

1

0

High-throughput

0.249

Low

460354

SYV
Valine--tRNA ligase, mitochondrial

1

0

Small-scale

0.249

Low

504328

RL31A
Large ribosomal subunit protein eL31A

1

0

High-throughput

0.249

Low

514746

RS18A
Small ribosomal subunit protein uS13A

1

0

High-throughput

0.249

Low

558815

CAF20
Cap-associated protein CAF20

1

0

High-throughput

0.249

Low

613779

MDM10
Mitochondrial distribution and morphology protein 10

1

0

High-throughput

0.249

Low

647173

RPC2
DNA-directed RNA polymerase III subunit RPC2

1

0

High-throughput

0.249

Low

704694

PRR1
Serine/threonine-protein kinase PRR1

1

0

High-throughput

0.249

Low

707742

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.249

Low

709891

BMH1
Protein BMH1

1

0

High-throughput

0.249

Low

735078

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

0

High-throughput

0.249

Low

747962

SMY2
Protein SMY2

1

0

High-throughput

0.249

Low

748480

SC61A
Protein transport protein SEC61

1

0

High-throughput

0.249

Low

792161

GBLP
Small ribosomal subunit protein RACK1

1

0

High-throughput

0.249

Low

793339

SYG
Glycine--tRNA ligase 1, mitochondrial

1

0

Small-scale

0.249

Low

795119

NU170
Nucleoporin NUP170

1

0

Small-scale

0.249

Low

812514

LAA1
AP-1 accessory protein LAA1

1

0

High-throughput

0.249

Low

813423

PO152
Nucleoporin POM152

1

0

Small-scale

0.249

Low

826691

DSN1
Kinetochore-associated protein DSN1

1

0

High-throughput

0.249

Low

919149

MPP6
M-phase phosphoprotein 6 homolog

1

0

High-throughput

0.249

Low

919156

RS15
Small ribosomal subunit protein uS19

1

0

High-throughput

0.249

Low

919165

VMS1
tRNA endonuclease VMS1

1

0

High-throughput

0.249

Low

919169

SYRC
Arginine--tRNA ligase, cytoplasmic

1

0

Small-scale

0.249

Low

919175

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

0

High-throughput

0.249

Low

919183

VAM6
Vacuolar morphogenesis protein 6

1

0

High-throughput

0.249

Low

919188

SGO1
Shugoshin

1

0

High-throughput

0.249

Low

919190

RS10A
Small ribosomal subunit protein eS10A

1

0

High-throughput

0.249

Low

919194

PSF3
DNA replication complex GINS protein PSF3

1

0

High-throughput

0.238

Low

486264

TBA1
Tubulin alpha-1 chain

1

0

High-throughput

0.232

Low

579798

HSC82
ATP-dependent molecular chaperone HSC82

1

0

High-throughput

0.232

Low

816327

HSP7E
Heat shock protein SSC3, mitochondrial

1

0

High-throughput

0.232

Low

919181

SWA2
Auxilin-like clathrin uncoating factor SWA2

1

0

High-throughput

0.232

Low

919199

HSP42
Heat shock protein 42

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025