HitPredict

Interactor 1: RAN (P62826)
GTP-binding nuclear protein Ran (EC 3.6.5.-) (Androgen receptor-associated protein 24) (GTPase Ran) (Ras-like protein TC4) (Ras-related nuclear protein)
Gene: RAN

Interactor 2: RGPD5 (Q99666)
RANBP2-like and GRIP domain-containing protein 5/6 (Ran-binding protein 2-like 1/2) (RanBP2-like 1/2) (RanBP2L1) (RanBP2L2) (Sperm membrane protein BS-63)
Gene: RGPD5

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	1.00	0.863

Property	Details
Experiments	28514442, 33961781, 21988832
Identification Methods	affinity chromatography technology, two hybrid, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	Rab_bind~Ras, Ran_BP1~Ras
Common GO terms	GO:0005643 - nuclear pore GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 216 Hs			1 1765
+	Hs
		152774 RAN_HUMAN (1-216): 7.75e-79: 237: 100.00		RGPD8_HUMAN (1-1765): 0: 2162: 99.49
+	Hs
		483422 RAN_HUMAN (1-216): 7.75e-79: 237: 100.00		RGPD2_HUMAN (1-1760): 0: 2110: 93.41
+	Hs
		63882 RAN_HUMAN (1-216): 7.75e-79: 237: 100.00		RGPD3_HUMAN (1-1757): 0: 2109: 95.56
+	Hs
		483392 RAN_HUMAN (1-216): 7.75e-79: 237: 100.00		RGPD1_HUMAN (26-1760): 0: 2095: 93.83
+	At
		784989 RAN1_ARATH (1-216): 1.39e-95: 279: 73.52		RBP1B_ARATH (1306-1504): 8.22e-41: 152: 31.10
+	At
		784998 RAN2_ARATH (1-215): 1.36e-88: 261: 74.77		RBP1B_ARATH (1306-1504): 8.22e-41: 152: 31.10
+	At
		784994 RAN1_ARATH (1-216): 1.39e-95: 279: 73.52		RBP1A_ARATH (1010-1239): 2.67e-31: 125: 26.09
+	At
		1210453 RAN3_ARATH (1-215): 9.1e-84: 249: 74.31		RBP1B_ARATH (1306-1504): 8.22e-41: 152: 31.10
+	Ce
		184995 RAN_CAEEL (3-205): 3.44e-97: 283: 88.18		Q86G90_CAEEL (758-1464): 3.05e-25: 116: 17.05
+	Ce
		184992 RAN_CAEEL (3-205): 3.44e-97: 283: 88.18		Q21021_CAEEL (779-1464): 1.32e-24: 114: 17.19
+	Xl
		193796 RAN_XENLA (1-216): 7.81e-80: 239: 98.15		O42193_XENLA (1310-1516): 4.13e-42: 155: 30.95
+	Sc
		698847 GSP1_YEAST (1-214): 5.23e-83: 247: 80.56		YRB1_YEAST (995-1173): 1.27e-38: 145: 43.24
+	Sc
		691616 GSP1_YEAST (1-214): 5.23e-83: 247: 80.56		NUP2_YEAST (698-1171): 1.67e-33: 142: 18.33
+	At
		785000 RAN2_ARATH (1-215): 1.36e-88: 261: 74.77		RBP1A_ARATH (1010-1239): 2.67e-31: 125: 26.09
+	Sp
		660086 SPI1_SCHPO (1-214): 1.23e-84: 251: 80.84		RANG_SCHPO (1269-1469): 3.01e-34: 133: 30.73
+	At
		784991 RAN1_ARATH (1-216): 1.39e-95: 279: 73.52		NU50A_ARATH (793-1198): 3.2e-22: 103: 16.87
+	At
		1210455 RAN3_ARATH (1-215): 9.1e-84: 249: 74.31		RBP1A_ARATH (1010-1239): 2.67e-31: 125: 26.09
+	Sc
		698835 GSP1_YEAST (1-214): 5.23e-83: 247: 80.56		YRB2_YEAST (879-1163): 7.39e-31: 127: 18.00
+	Hs
		834710 RAN_HUMAN (1-216): 7.75e-79: 237: 100.00		RBP2_HUMAN (686-1191): 1.36e-30: 134: 23.67
+	Hs
		796725 RAN_HUMAN (1-216): 7.75e-79: 237: 100.00		RANG_HUMAN (1014-1207): 2.48e-27: 113: 37.88