HitPredict

Interactor 1: UB2D2 (P62837)
Ubiquitin-conjugating enzyme E2 D2 (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme D2) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme D2) (Ubiquitin carrier protein D2) (Ubiquitin-conjugating enzyme E2(17)KB 2) (Ubiquitin-conjugating enzyme E2-17 kDa 2) (Ubiquitin-protein ligase D2) (p53-regulated ubiquitin-conjugating enzyme 1)
Gene: UBE2D2

Interactor 2: UBA5 (Q9GZZ9)
Ubiquitin-like modifier-activating enzyme 5 (Ubiquitin-activating enzyme 5) (ThiFP1) (UFM1-activating enzyme) (Ubiquitin-activating enzyme E1 domain-containing protein 1)
Gene: UBA5

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	29643511
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	ThiF~UQ_con
Common GO terms	GO:0005524 - ATP binding GO:0005634 - nucleus GO:0005829 - cytosol
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 147 Hs			1 404
+	Hs
		919796 UB2D2_HUMAN (1-147): 9.5e-83: 241: 100.00		UBA3_HUMAN (6-247): 2.13e-65: 217: 19.77
+	Hs
		1282360 UB2E3_HUMAN (4-146): 3.05e-74: 221: 66.43		SAE2_HUMAN (57-233): 2.97e-53: 189: 26.40
+	Hs
		607190 UB2D4_HUMAN (1-147): 2.21e-83: 243: 93.20		UBA1_HUMAN (20-218): 5.28e-32: 130: 13.15
+	Hs
		607026 UB2D1_HUMAN (1-147): 7.06e-83: 241: 89.12		UBA1_HUMAN (20-218): 5.28e-32: 130: 13.15
+	Hs
		607050 UB2D2_HUMAN (1-147): 9.5e-83: 241: 100.00		UBA1_HUMAN (20-218): 5.28e-32: 130: 13.15
+	Hs
		607039 UB2D3_HUMAN (1-147): 1.54e-81: 238: 97.28		UBA1_HUMAN (20-218): 5.28e-32: 130: 13.15
+	Hs
		607136 UB2E2_HUMAN (4-146): 5.85e-75: 223: 65.73		UBA1_HUMAN (20-218): 5.28e-32: 130: 13.15
+	Sp
		293848 UBC4_SCHPO (1-147): 1.21e-80: 236: 84.35		UBA1_SCHPO (35-300): 2e-27: 116: 13.11
+	Hs
		607129 UB2E3_HUMAN (4-146): 3.05e-74: 221: 66.43		UBA1_HUMAN (20-218): 5.28e-32: 130: 13.15
+	Sc
		549788 UBC4_YEAST (3-147): 1.04e-79: 233: 80.00		UBA1_YEAST (44-218): 2.65e-27: 116: 19.21
+	Hs
		607028 UB2E1_HUMAN (4-146): 8.81e-73: 217: 65.73		UBA1_HUMAN (20-218): 5.28e-32: 130: 13.15
+	Hs
		607023 UBE2A_HUMAN (2-144): 1.41e-70: 210: 39.16		UBA1_HUMAN (20-218): 5.28e-32: 130: 13.15
+	Hs
		607054 UBE2B_HUMAN (2-144): 5.71e-70: 209: 37.76		UBA1_HUMAN (20-218): 5.28e-32: 130: 13.15
+	Hs
		607042 UBE2N_HUMAN (4-147): 7.67e-69: 206: 47.22		UBA1_HUMAN (20-218): 5.28e-32: 130: 13.15
+	Sp
		251976 UBC1_SCHPO (4-146): 6.92e-45: 147: 45.83		UBA1_SCHPO (35-300): 2e-27: 116: 13.11
+	Sp
		293851 UBC14_SCHPO (8-146): 5.28e-43: 140: 47.14		UBA1_SCHPO (35-300): 2e-27: 116: 13.11
+	Dm
		715098 UBE2N_DROME (4-147): 8.8e-45: 145: 49.31		Q8T0L3_DROME (47-210): 4.46e-18: 88.7: 16.36