Interactor 1: PLK1 (P53350)
Serine/threonine-protein kinase PLK1 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-1) (Serine/threonine-protein kinase 13) (STPK13)
Gene: PLK1
Interactor 2: FADD (Q13158)
FAS-associated death domain protein (FAS-associating death domain-containing protein) (Growth-inhibiting gene 3 protein) (Mediator of receptor induced toxicity)
Gene: FADD
Species: Homo sapiens
Source: intact
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.60 | 1.00 | 0.780 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 20890306 |
| Identification Methods | anti bait coimmunoprecipitation, molecular sieving, protein kinase assay, immunodepleted coimmunoprecipitation, pull down |
| Interaction Type | physical association, phosphorylation reaction, direct interaction |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | DED~Pkinase |
| Common GO terms | GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0045862 - positive regulation of proteolysis |
| Homologous interactions | 2 |
Homologous interactions
Color coding for hit scores 
|
|
|||||||||||||
| + | Hs |   |
 |
|||||||||||
| + | Hs | |
|
|||||||||||
Service provided by Combinatics, Japan
Last updated: 11Aug2025
