HitPredict

Interactor 1: RBX1 (P62877)
E3 ubiquitin-protein ligase RBX1 (EC 2.3.2.27) (EC 2.3.2.32) (E3 ubiquitin-protein transferase RBX1) (Protein ZYP) (RING finger protein 75) (RING-box protein 1) (Rbx1) (Regulator of cullins 1) (ROC1) [Cleaved into: E3 ubiquitin-protein ligase RBX1, N-terminally processed (E3 ubiquitin-protein transferase RBX1, N-terminally processed)]
Gene: RBX1

Interactor 2: CUL4A (Q13619)
Cullin-4A (CUL-4A)
Gene: CUL4A

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.98 1.00 0.990

The method score is based on:

Property Details
Experiments 19250909, 27203177, 29958295, 30349055, 12481031, 33961781, 10230407, 33504946, 22405651, 17452440, 26976604, 26990986, 27113764, 27203182, 30352932, 30945288, 32140073, 31973889, 32235678, 33759138 and 8 others

more...
Identification Methods enzymatic study, affinity chromatography technology, two hybrid, biochemical, pull down, anti tag coimmunoprecipitation
Interaction Type direct interaction, physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains Cullin~zf-rbx1, Cullin_Nedd8~zf-rbx1
Common GO terms GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
GO:0006281 - DNA repair
GO:0006974 - DNA damage response
and 10 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 108
Hs

1 759
+ Mm
+ Mm
+ Hs
+ Dm
+ At
+ At
+ At
+ Hs
+ Dm
+ Hs
+ Mm
+ At
+ Hs
+ Dm
+ Sp
+ Dm
+ Sp
+ Ce
+ Hs
+ Ce

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024