HitPredict

Interactor 1: RBX1 (P62877)
E3 ubiquitin-protein ligase RBX1 (EC 2.3.2.27) (EC 2.3.2.32) (E3 ubiquitin-protein transferase RBX1) (Protein ZYP) (RING finger protein 75) (RING-box protein 1) (Rbx1) (Regulator of cullins 1) (ROC1) [Cleaved into: E3 ubiquitin-protein ligase RBX1, N-terminally processed (E3 ubiquitin-protein transferase RBX1, N-terminally processed)]
Gene: RBX1

Interactor 2: KEAP1 (Q14145)
Kelch-like ECH-associated protein 1 (Cytosolic inhibitor of Nrf2) (INrf2) (Kelch-like protein 19)
Gene: KEAP1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.90	0.60	0.738

The method score is based on:

Property	Details
Experiments	35947662, 20027226, 15572695, 16449638, 15983046, 20421418, 22558124
Identification Methods	enzymatic study, affinity chromatography technology
Interaction Type	direct interaction, physical association

The annotation score is based on:

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0006511 - ubiquitin-dependent protein catabolic process GO:0016567 - protein ubiquitination and 4 others more... GO:0031463 - Cul3-RING ubiquitin ligase complex GO:0032436 - positive regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0061629 - RNA polymerase II-specific DNA-binding transcription factor binding GO:1902883 - negative regulation of response to oxidative stress
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1	108
Hs

1	624

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024