HitPredict

Interactor 1: RBX1 (P62877)
E3 ubiquitin-protein ligase RBX1 (EC 2.3.2.27) (EC 2.3.2.32) (E3 ubiquitin-protein transferase RBX1) (Protein ZYP) (RING finger protein 75) (RING-box protein 1) (Rbx1) (Regulator of cullins 1) (ROC1) [Cleaved into: E3 ubiquitin-protein ligase RBX1, N-terminally processed (E3 ubiquitin-protein transferase RBX1, N-terminally processed)]
Gene: RBX1

Interactor 2: UB2E2 (Q96LR5)
Ubiquitin-conjugating enzyme E2 E2 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme E2) (UbcH8) (Ubiquitin carrier protein E2) (Ubiquitin-protein ligase E2)
Gene: UBE2E2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	21628527
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	UQ_con~zf-rbx1
Common GO terms	GO:0005634 - nucleus GO:0006974 - DNA damage response GO:0070936 - protein K48-linked ubiquitination
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 108 Hs			1 201
+	Mm
		854552 RBX1_MOUSE (1-108): 5.69e-51: 157: 100.00		UB2E3_MOUSE (1-201): 6.37e-85: 251: 79.71
+	Hs
		921379 RBX1_HUMAN (1-108): 5.69e-51: 157: 100.00		UB2E3_HUMAN (1-201): 6.37e-85: 251: 79.71
+	Hs
		921482 RBX1_HUMAN (1-108): 5.69e-51: 157: 100.00		UB2D4_HUMAN (55-200): 9.37e-83: 243: 63.01
+	Hs
		919703 RBX1_HUMAN (1-108): 5.69e-51: 157: 100.00		UB2D2_HUMAN (55-200): 2.8e-82: 242: 64.38
+	Mm
		919923 RBX1_MOUSE (1-108): 5.69e-51: 157: 100.00		UB2D2_MOUSE (55-200): 2.8e-82: 242: 64.38
+	Hs
		849303 RBX1_HUMAN (1-108): 5.69e-51: 157: 100.00		UB2D1_HUMAN (55-200): 1.23e-81: 240: 61.64
+	Mm
		895979 RBX1_MOUSE (1-108): 5.69e-51: 157: 100.00		UB2D1_MOUSE (55-200): 1.23e-81: 240: 61.64
+	Hs
		851800 RBX1_HUMAN (1-108): 5.69e-51: 157: 100.00		UB2E1_HUMAN (28-201): 6.5e-80: 238: 89.71
+	Hs
		895771 RBX1_HUMAN (1-108): 5.69e-51: 157: 100.00		UB2D3_HUMAN (55-200): 1.28e-80: 238: 63.70
+	Mm
		895973 RBX1_MOUSE (1-108): 5.69e-51: 157: 100.00		UB2D3_MOUSE (55-200): 1.28e-80: 238: 63.70
+	Ce
		715111 RBX1_CAEEL (2-108): 1.48e-44: 141: 79.44		UBC2_CAEEL (55-200): 6.51e-82: 241: 65.07
+	Sc
		549843 RBX1_YEAST (17-107): 8.73e-38: 125: 64.84		UBC4_YEAST (54-200): 4.63e-81: 239: 63.95
+	Sc
		549867 RBX1_YEAST (17-107): 8.73e-38: 125: 64.84		UBC5_YEAST (54-200): 3.63e-80: 237: 64.63
+	Ce
		1095359 RBX1_CAEEL (2-108): 1.48e-44: 141: 79.44		UBC13_CAEEL (57-200): 4.15e-70: 211: 49.31
+	Hs
		1354003 RBX2_HUMAN (20-107): 8.91e-31: 107: 50.00		UB2D4_HUMAN (55-200): 9.37e-83: 243: 63.01
+	Hs
		919890 RBX2_HUMAN (20-107): 8.91e-31: 107: 50.00		UB2D2_HUMAN (55-200): 2.8e-82: 242: 64.38
+	Hs
		849472 RBX2_HUMAN (20-107): 8.91e-31: 107: 50.00		UB2D1_HUMAN (55-200): 1.23e-81: 240: 61.64
+	Ce
		715108 APC11_CAEEL (5-105): 1.28e-29: 104: 28.97		UBC2_CAEEL (55-200): 6.51e-82: 241: 65.07
+	Hs
		895936 RBX2_HUMAN (20-107): 8.91e-31: 107: 50.00		UB2D3_HUMAN (55-200): 1.28e-80: 238: 63.70
+	Hs
		849463 APC11_HUMAN (20-105): 8.33e-28: 98.6: 37.08		UB2D1_HUMAN (55-200): 1.23e-81: 240: 61.64