HitPredict

Interactor 1: GBB2 (P62879)
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 (G protein subunit beta-2) (Transducin beta chain 2)
Gene: GNB2

Interactor 2: GBG5 (P63218)
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5
Gene: GNG5

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.85	1.00	0.923

Property	Details
Experiments	33961781, 8636150, 19168127, 28514442, 19376773
Identification Methods	affinity chromatography technology, two hybrid, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	G-gamma~WD40
Common GO terms	GO:0003924 - GTPase activity GO:0005834 - heterotrimeric G-protein complex GO:0005886 - plasma membrane GO:0007186 - G protein-coupled receptor signaling pathway GO:0016020 - membrane and 1 others more... GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 340 Hs			1 68
+	Hs
		229238 GBB2_HUMAN (1-340): 2.89e-111: 328: 100.00		GBG7_HUMAN (1-68): 1.09e-27: 96.2: 51.47
+	Hs
		229245 GBB4_HUMAN (1-340): 3.14e-110: 326: 90.00		GBG7_HUMAN (1-68): 1.09e-27: 96.2: 51.47
+	Hs
		921761 GBB2_HUMAN (1-340): 2.89e-111: 328: 100.00		GBG12_HUMAN (2-68): 5.4e-26: 92: 46.27
+	Hs
		887097 GBB2_HUMAN (1-340): 2.89e-111: 328: 100.00		GBG2_HUMAN (2-68): 6.55e-26: 91.6: 48.53
+	Hs
		921516 GBB2_HUMAN (1-340): 2.89e-111: 328: 100.00		GBG3_HUMAN (1-68): 1.3e-25: 90.9: 46.38
+	Hs
		887126 GBB4_HUMAN (1-340): 3.14e-110: 326: 90.00		GBG2_HUMAN (2-68): 6.55e-26: 91.6: 48.53
+	Hs
		837687 GBB2_HUMAN (1-340): 2.89e-111: 328: 100.00		GBG10_HUMAN (1-68): 5.93e-25: 89.3: 52.94
+	Hs
		929157 GBB4_HUMAN (1-340): 3.14e-110: 326: 90.00		GBG3_HUMAN (1-68): 1.3e-25: 90.9: 46.38
+	Hs
		837673 GBB2_HUMAN (1-340): 2.89e-111: 328: 100.00		GBG4_HUMAN (2-68): 1.64e-24: 88.2: 45.59
+	Hs
		837704 GBB4_HUMAN (1-340): 3.14e-110: 326: 90.00		GBG10_HUMAN (1-68): 5.93e-25: 89.3: 52.94
+	Hs
		837682 GBB4_HUMAN (1-340): 3.14e-110: 326: 90.00		GBG4_HUMAN (2-68): 1.64e-24: 88.2: 45.59
+	Hs
		921771 GBB2_HUMAN (1-340): 2.89e-111: 328: 100.00		GBG8_HUMAN (2-68): 1.13e-23: 85.8: 44.12
+	Hs
		929176 GBB4_HUMAN (1-340): 3.14e-110: 326: 90.00		GBG5_HUMAN (1-68): 5.15e-24: 86.6: 100.00
+	Hs
		1334919 GBB4_HUMAN (1-340): 3.14e-110: 326: 90.00		GBG13_HUMAN (7-68): 9.95e-21: 78.5: 25.81
+	Hs
		150115 GBB2_HUMAN (1-340): 2.89e-111: 328: 100.00		GBGT2_HUMAN (10-67): 1.31e-18: 73.1: 31.03
+	Hs
		921515 GBB2_HUMAN (1-340): 2.89e-111: 328: 100.00		GBG1_HUMAN (9-67): 1.93e-18: 72.7: 28.33
+	Hs
		929139 Q6FHM2_HUMAN (1-340): 2.89e-111: 328: 100.00		GBG1_HUMAN (9-67): 1.93e-18: 72.7: 28.33
+	Hs
		150117 GBB4_HUMAN (1-340): 3.14e-110: 326: 90.00		GBGT2_HUMAN (10-67): 1.31e-18: 73.1: 31.03
+	Hs
		902497 GBB4_HUMAN (1-340): 3.14e-110: 326: 90.00		GBG11_HUMAN (9-67): 1.67e-18: 73.1: 32.20
+	Hs
		929145 GBB4_HUMAN (1-340): 3.14e-110: 326: 90.00		GBG1_HUMAN (9-67): 1.93e-18: 72.7: 28.33