Protein: PGTB2
Geranylgeranyl transferase type-2 subunit beta (EC 2.5.1.60) (Geranylgeranyl transferase type II subunit beta) (GGTase-II-beta) (Rab geranyl-geranyltransferase subunit beta) (Rab GG transferase beta) (Rab GGTase beta) (Rab geranylgeranyltransferase subunit beta) (Type II protein geranyl-geranyltransferase subunit beta)

Gene: PGTB2, RABGGTB
Organism: Homo sapiens
Interactions: 90
UniProt ID: P53611

Gene Ontology (top 5):
GO:0004663 - Rab geranylgeranyltransferase activity
GO:0005829 - cytosol
GO:0005886 - plasma membrane
GO:0005968 - Rab-protein geranylgeranyltransferase complex
GO:0006888 - endoplasmic reticulum to Golgi vesicle-mediated transport

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

921553

PGTA
Geranylgeranyl transferase type-2 subunit alpha

7

20

High-throughput

0.964

High

192221

YKT6
Synaptobrevin homolog YKT6

4

2

High-throughput

0.892

High

921548

PTAR1
Protein prenyltransferase alpha subunit repeat-containing protein 1

5

20

High-throughput

0.827

High

921533

TP4A2
Protein tyrosine phosphatase type IVA 2

5

4

Small-scale

0.719

High

921588

RAP2C
Ras-related protein Rap-2c

4

3

High-throughput

0.697

High

518587

RAP2A
Ras-related protein Rap-2a

4

3

High-throughput

0.691

High

921531

NOTC2
Neurogenic locus notch homolog protein 2

4

1

High-throughput

0.691

High

921534

RAB31
Ras-related protein Rab-31

4

7

High-throughput

0.691

High

921583

TRI33
E3 ubiquitin-protein ligase TRIM33

4

1

High-throughput

0.691

High

245794

PI51C
Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma

3

2

High-throughput

0.667

High

322713

RHBT3
Rho-related BTB domain-containing protein 3

3

2

High-throughput

0.667

High

374491

RASH
GTPase HRas

3

4

High-throughput

0.667

High

921532

RB40B
Ras-related protein Rab-40B

3

5

High-throughput

0.667

High

921535

GIT2
ARF GTPase-activating protein GIT2

3

1

High-throughput

0.667

High

921538

NCOA1
Nuclear receptor coactivator 1

3

1

High-throughput

0.667

High

921563

RB40C
Ras-related protein Rab-40C

3

4

High-throughput

0.667

High

921564

PI51A
Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha

3

2

High-throughput

0.667

High

921582

NOTC3
Neurogenic locus notch homolog protein 3

3

1

High-throughput

0.667

High

921584

GIT1
ARF GTPase-activating protein GIT1

3

1

High-throughput

0.667

High

921573

RAB6B
Ras-related protein Rab-6B

3

4

High-throughput

0.662

High

292434

PALM
Paralemmin-1

4

0

High-throughput

0.661

High

878421

PAXI
Paxillin

4

0

High-throughput

0.661

High

921536

I5P1
Inositol polyphosphate-5-phosphatase A

4

0

High-throughput

0.661

High

631138

RAB5A
Ras-related protein Rab-5A

3

6

High-throughput

0.657

High

921528

RRAS2
Ras-related protein R-Ras2

3

5

High-throughput

0.650

High

921526

WDR4
tRNA

3

0

High-throughput

0.646

High

921576

B4GT7
Beta-1,4-galactosyltransferase 7

3

0

High-throughput

0.646

High

651632

KAPCB
cAMP-dependent protein kinase catalytic subunit beta

3

0

High-throughput

0.638

High

921537

ARHG6
Rho guanine nucleotide exchange factor 6

3

0

High-throughput

0.638

High

921542

BORA
Protein aurora borealis

3

0

High-throughput

0.638

High

921558

ZCCHL
Zinc finger CCCH-type antiviral protein 1-like

3

0

High-throughput

0.638

High

921559

PP16A
Protein phosphatase 1 regulatory subunit 16A

3

0

High-throughput

0.638

High

921565

MCMBP
Mini-chromosome maintenance complex-binding protein

3

0

High-throughput

0.638

High

921575

CACO1
Calcium-binding and coiled-coil domain-containing protein 1

3

0

High-throughput

0.638

High

921579

AKA11
A-kinase anchor protein 11

3

0

High-throughput

0.638

High

921554

TP4A1
Protein tyrosine phosphatase type IVA 1

4

4

High-throughput

0.630

High

901748

RAB9A
Ras-related protein Rab-9A

2

7

High-throughput

0.628

High

921560

FXL20
F-box/LRR-repeat protein 20

2

1

High-throughput

0.628

High

373855

RASN
GTPase NRas

2

3

High-throughput

0.611

High

921572

RAB9B
Ras-related protein Rab-9B

2

6

High-throughput

0.611

High

921590

PRC2C
Protein PRRC2C

2

1

High-throughput

0.611

High

921562

PSKH2
Serine/threonine-protein kinase H2

3

1

High-throughput

0.609

High

921578

HOOK1
Protein Hook homolog 1

3

2

High-throughput

0.609

High

725366

KAP1
cAMP-dependent protein kinase type I-beta regulatory subunit

2

0

High-throughput

0.585

High

921555

RAB7B
Ras-related protein Rab-7b

2

8

High-throughput

0.574

High

921556

RAB37
Ras-related protein Rab-37

1

3

High-throughput

0.560

High

58800

PIPSL
Putative PIP5K1A and PSMD4-like protein

2

3

High-throughput

0.552

High

921549

TMM25
Transmembrane protein 25

1

0

High-throughput

0.549

High

686563

RAE2
Rab proteins geranylgeranyltransferase component A 2

1

1

High-throughput

0.536

High

921571

UBE2Z
Ubiquitin-conjugating enzyme E2 Z

1

2

High-throughput

0.536

High

921581

RAB26
Ras-related protein Rab-26

1

4

High-throughput

0.536

High

921545

NPSR1
Neuropeptide S receptor

1

0

High-throughput

0.518

High

921587

SHLB1
Endophilin-B1

1

0

High-throughput

0.518

High

921541

RRAGB
Ras-related GTP-binding protein B

1

0

High-throughput

0.513

High

669854

MCM3
DNA replication licensing factor MCM3

1

1

High-throughput

0.489

High

521261

ARAF
Serine/threonine-protein kinase A-Raf

1

0

Small-scale

0.486

High

630411

RAB3A
Ras-related protein Rab-3A

1

3

Small-scale

0.481

High

695011

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.479

High

921546

TRI67
Tripartite motif-containing protein 67

1

3

High-throughput

0.479

High

921570

RAB17
Ras-related protein Rab-17

1

4

High-throughput

0.479

High

921580

FBXL2
F-box/LRR-repeat protein 2

1

1

Small-scale

0.479

High

921589

M4K5
Mitogen-activated protein kinase kinase kinase kinase 5

1

1

High-throughput

0.479

High

921529

RNF4
E3 ubiquitin-protein ligase RNF4

1

0

High-throughput

0.458

High

921539

CL16A
Protein CLEC16A

1

0

High-throughput

0.458

High

921544

LMBRL
Protein LMBR1L

1

0

High-throughput

0.458

High

921552

TIP
T-cell immunomodulatory protein

1

0

High-throughput

0.458

High

921568

MLP3B
Microtubule-associated protein 1 light chain 3 beta

1

0

High-throughput

0.458

High

921569

SHRPN
Sharpin

1

0

Small-scale

0.458

High

921577

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

520681

RRAS
Ras-related protein R-Ras

1

9

High-throughput

0.445

High

921527

RAB8A
Ras-related protein Rab-8A

1

2

Small-scale

0.445

High

767773

RFA3
Replication protein A 14 kDa subunit

1

1

High-throughput

0.437

High

250227

VINEX
Vinexin

1

0

High-throughput

0.426

High

921540

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

0

High-throughput

0.426

High

921567

ZDHC5
Palmitoyltransferase ZDHHC5

1

0

High-throughput

0.426

High

921574

DECR2
Peroxisomal 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing]

1

0

High-throughput

0.426

High

921530

FOXK1
Forkhead box protein K1

3

0

High-throughput

0.347

High

921543

ABRX1
BRCA1-A complex subunit Abraxas 1

3

0

High-throughput

0.347

High

921550

F219A
Protein FAM219A

3

0

High-throughput

0.347

High

921551

PGBD5
PiggyBac transposable element-derived protein 5

3

0

High-throughput

0.347

High

921557

TRM2B
tRNA

3

0

High-throughput

0.347

High

921566

GNB1L
Guanine nucleotide-binding protein subunit beta-like protein 1

3

0

High-throughput

0.347

High

921585

ACOT9
Acyl-coenzyme A thioesterase 9, mitochondrial

3

0

High-throughput

0.347

High

665917

IBP6
Insulin-like growth factor-binding protein 6

2

0

High-throughput

0.316

High

921547

TAFA1
Chemokine-like protein TAFA-1

1

0

High-throughput

0.299

High

472288

CFAH
Complement factor H

1

0

Small-scale

0.249

Low

588283

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.249

Low

755861

MCM5
DNA replication licensing factor MCM5

1

0

High-throughput

0.249

Low

921561

MAGD4
Melanoma-associated antigen D4

1

0

High-throughput

0.249

Low

921586

AAR2
Protein AAR2 homolog

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025