Protein: FNTB
Protein farnesyltransferase subunit beta (FTase-beta) (EC 2.5.1.58) (CAAX farnesyltransferase subunit beta) (Ras proteins prenyltransferase subunit beta)

Gene: FNTB
Organism: Homo sapiens
Interactions: 94
UniProt ID: P49356

Gene Ontology (top 5):
GO:0004660 - protein farnesyltransferase activity
GO:0005829 - cytosol
GO:0005875 - microtubule associated complex
GO:0005965 - protein farnesyltransferase complex
GO:0006629 - lipid metabolic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

881641

FNTA
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha

11

20

Small-scale

0.979

High

192213

YKT6
Synaptobrevin homolog YKT6

3

2

High-throughput

0.861

High

881708

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

5

1

High-throughput

0.718

High

457062

CAN1
Calpain-1 catalytic subunit

3

3

High-throughput

0.667

High

881695

NP1L1
Nucleosome assembly protein 1-like 1

3

1

High-throughput

0.667

High

881734

HOOK2
Protein Hook homolog 2

3

2

High-throughput

0.667

High

49084

BLT3B
Bridge-like lipid transfer protein family member 3B

3

0

High-throughput

0.638

High

507114

UBB
Polyubiquitin-B [Cleaved into: Ubiquitin]

3

0

High-throughput

0.638

High

635117

ICAL
Calpastatin

3

0

High-throughput

0.638

High

648266

ENPP1
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1

3

0

High-throughput

0.638

High

881693

CENPF
Centromere protein F

3

0

High-throughput

0.638

High

881713

DHX57
Putative ATP-dependent RNA helicase DHX57

3

0

High-throughput

0.638

High

881717

NDUF7
Protein arginine methyltransferase NDUFAF7, mitochondrial

3

0

High-throughput

0.638

High

881733

SPDLY
Protein Spindly

3

0

High-throughput

0.638

High

881751

GRIP1
Glutamate receptor-interacting protein 1

3

0

High-throughput

0.638

High

881694

PGTB1
Geranylgeranyl transferase type-1 subunit beta

1

2

High-throughput

0.618

High

881720

HOOK3
Protein Hook homolog 3

3

2

High-throughput

0.609

High

881732

TP4A1
Protein tyrosine phosphatase type IVA 1

3

4

High-throughput

0.609

High

377028

NEU2
Vasopressin-neurophysin 2-copeptin

2

0

High-throughput

0.602

High

881696

DCAF7
DDB1- and CUL4-associated factor 7

2

0

High-throughput

0.602

High

881703

RL18
Large ribosomal subunit protein eL18

2

0

High-throughput

0.602

High

881724

CBPA6
Carboxypeptidase A6

2

0

High-throughput

0.602

High

881726

ARFG1
ADP-ribosylation factor GTPase-activating protein 1

2

0

High-throughput

0.602

High

881735

KCNS3
Delayed-rectifier potassium channel regulatory subunit KCNS3

2

0

High-throughput

0.602

High

881705

TP4A2
Protein tyrosine phosphatase type IVA 2

2

4

High-throughput

0.601

High

881710

GLYR1
Cytokine-like nuclear factor N-PAC

2

0

High-throughput

0.585

High

241067

PRKN
E3 ubiquitin-protein ligase parkin

2

1

High-throughput

0.584

High

638836

AGT1
Alanine--glyoxylate aminotransferase

2

0

High-throughput

0.580

High

881725

ATPF2
ATP synthase mitochondrial F1 complex assembly factor 2

2

0

High-throughput

0.580

High

881741

SMG9
Nonsense-mediated mRNA decay factor SMG9

2

0

High-throughput

0.580

High

881697

RRAS2
Ras-related protein R-Ras2

2

5

High-throughput

0.558

High

224951

TLX3
T-cell leukemia homeobox protein 3

2

1

High-throughput

0.553

High

881748

HDAC6
Protein deacetylase HDAC6

1

0

Small-scale

0.537

High

300319

KRT34
Keratin, type I cuticular Ha4

1

1

High-throughput

0.536

High

605975

CAN2
Calpain-2 catalytic subunit

1

3

High-throughput

0.536

High

881709

K1H1
Keratin, type I cuticular Ha1

1

1

High-throughput

0.536

High

881722

MINK1
Misshapen-like kinase 1

1

1

High-throughput

0.536

High

881743

LATS2
Serine/threonine-protein kinase LATS2

1

1

High-throughput

0.536

High

615672

RL17
Large ribosomal subunit protein uL22

1

0

High-throughput

0.513

High

858842

RL27A
Large ribosomal subunit protein uL15

1

0

High-throughput

0.513

High

881698

ACTA
Actin, aortic smooth muscle

1

0

High-throughput

0.513

High

881699

RL23A
Large ribosomal subunit protein uL23

1

0

High-throughput

0.513

High

881706

SBP1
Methanethiol oxidase

1

0

High-throughput

0.513

High

881707

DGKZ
Diacylglycerol kinase zeta

1

0

High-throughput

0.513

High

881711

ZN691
Zinc finger protein 691

1

0

High-throughput

0.513

High

881721

F131B
Protein FAM131B

1

0

High-throughput

0.513

High

881729

SNX33
Sorting nexin-33

1

0

High-throughput

0.513

High

881730

LPIN2
Phosphatidate phosphatase LPIN2

1

0

High-throughput

0.513

High

881737

OVOL2
Transcription factor Ovo-like 2

1

0

High-throughput

0.513

High

881742

ARNT2
Aryl hydrocarbon receptor nuclear translocator 2

1

0

High-throughput

0.513

High

881749

INTU
Protein inturned

1

0

High-throughput

0.513

High

881718

SPRE1
Sprouty-related, EVH1 domain-containing protein 1

1

0

High-throughput

0.493

High

65515

CAN8
Calpain-8

1

3

High-throughput

0.489

High

881702

HME1
Homeobox protein engrailed-1

1

1

High-throughput

0.489

High

881727

CAMKV
CaM kinase-like vesicle-associated protein

1

1

High-throughput

0.489

High

412941

CPNS1
Calpain small subunit 1

1

3

High-throughput

0.479

High

881715

TRI67
Tripartite motif-containing protein 67

1

3

High-throughput

0.479

High

881739

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

2

High-throughput

0.479

High

290893

PPM1B
Protein phosphatase 1B

1

0

High-throughput

0.458

High

320638

UBXN7
UBX domain-containing protein 7

1

0

High-throughput

0.458

High

331845

GOSR1
Golgi SNAP receptor complex member 1

1

0

High-throughput

0.458

High

693601

RL10
Large ribosomal subunit protein uL16

1

0

High-throughput

0.458

High

881731

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

0

High-throughput

0.458

High

277330

TP4A3
Protein tyrosine phosphatase type IVA 3

1

4

High-throughput

0.437

High

767676

RFA3
Replication protein A 14 kDa subunit

1

1

High-throughput

0.437

High

404725

PRIO
Major prion protein

1

0

High-throughput

0.426

High

261125

NSMA
Sphingomyelin phosphodiesterase 2

3

0

High-throughput

0.347

High

881701

LMNB2
Lamin-B2

3

0

High-throughput

0.347

High

881704

TROAP
Tastin

3

0

High-throughput

0.347

High

881714

F117B
Protein FAM117B

3

0

High-throughput

0.347

High

881740

PITH1
PITH domain-containing protein 1

3

0

High-throughput

0.347

High

881745

FA53C
Protein FAM53C

3

0

High-throughput

0.347

High

881752

AUP1
Lipid droplet-regulating VLDL assembly factor AUP1

3

0

High-throughput

0.347

High

240067

KPRB
Phosphoribosyl pyrophosphate synthase-associated protein 2

2

0

High-throughput

0.328

High

881716

CEFIP
Cardiac-enriched FHL2-interacting protein

2

0

High-throughput

0.328

High

881736

LBHD1
LBH domain-containing protein 1

2

0

High-throughput

0.328

High

881744

AKIP
Small ribosomal subunit protein mS38

2

0

High-throughput

0.328

High

881750

T53G5
TP53-target gene 5 protein

2

0

High-throughput

0.328

High

63748

KRBA1
Protein KRBA1

2

0

High-throughput

0.316

High

725027

HXC8
Homeobox protein Hox-C8

2

0

High-throughput

0.316

High

881723

CCD24
Coiled-coil domain-containing protein 24

2

0

High-throughput

0.316

High

881738

APOL6
Apolipoprotein L6

2

0

High-throughput

0.316

High

326682

DUS14
Dual specificity protein phosphatase 14

1

0

High-throughput

0.279

Low

733306

CCR1
C-C chemokine receptor type 1

1

0

High-throughput

0.279

Low

871164

TFPI2
Tissue factor pathway inhibitor 2

1

0

High-throughput

0.279

Low

881700

RT11
Small ribosomal subunit protein uS11m

1

0

High-throughput

0.279

Low

881712

MRM1
rRNA methyltransferase 1, mitochondrial

1

0

High-throughput

0.279

Low

881719

DSG4
Desmoglein-4

1

0

High-throughput

0.279

Low

881728

LRC15
Leucine-rich repeat-containing protein 15

1

0

High-throughput

0.279

Low

881746

CWC15
Spliceosome-associated protein CWC15 homolog

1

0

High-throughput

0.279

Low

881747

P2RX2
P2X purinoceptor 2

1

0

High-throughput

0.279

Low

881753

CHCH2
Coiled-coil-helix-coiled-coil-helix domain-containing protein 2

1

0

High-throughput

0.279

Low

109381

G5E9A7
DM1 locus, WD repeat containing

1

0

High-throughput

0.268

Low

105558

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025