HitPredict

Interactor 1: FKB1A (P62942)
Peptidyl-prolyl cis-trans isomerase FKBP1A (PPIase FKBP1A) (EC 5.2.1.8) (12 kDa FK506-binding protein) (12 kDa FKBP) (FKBP-12) (Calstabin-1) (FK506-binding protein 1A) (FKBP-1A) (Immunophilin FKBP12) (Rotamase)
Gene: FKBP1A

Interactor 2: RYR3 (Q15413)
Ryanodine receptor 3 (RYR-3) (RyR3) (Brain ryanodine receptor-calcium release channel) (Brain-type ryanodine receptor) (Type 3 ryanodine receptor)
Gene: RYR3

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.60	1.00	0.778

Property	Details
Experiments	11598113, 11171121
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	FKBP_C~RYDR_ITPR, FKBP_C~SPRY
Common GO terms	GO:0016020 - membrane GO:0030018 - Z disc GO:0033017 - sarcoplasmic reticulum membrane GO:0070588 - calcium ion transmembrane transport
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 108 Hs			1 4870
+	Hs
		932945 FKB1B_HUMAN (1-108): 2.61e-52: 161: 83.33		RYR3_HUMAN (1-4870): 0: 7801: 100.00
+	Hs
		923825 FKB1A_HUMAN (1-108): 2e-54: 166: 100.00		ITPR1_HUMAN (4616-4856): 8.44e-104: 378: 30.93
+	Rn
		94032 FKB1A_RAT (1-108): 5.55e-54: 165: 97.22		RYR1_RAT (2507-2732): 5.18e-16: 88.7: 20.60
+	Mm
		93348 FKB1A_MOUSE (1-108): 3.43e-54: 166: 97.22		RYR1_MOUSE (2507-2712): 2.86e-15: 86.3: 20.48
+	Hs
		601658 FKB1A_HUMAN (1-108): 2e-54: 166: 100.00		RYR1_HUMAN (2507-2712): 3.38e-15: 86: 20.48
+	Oc
		514745 FKB1A_RABIT (1-108): 2e-54: 166: 100.00		RYR1_RABIT (2507-2712): 4.88e-15: 85.6: 20.48
+	Hs
		923834 FKB1A_HUMAN (1-108): 2e-54: 166: 100.00		RYR2_HUMAN (2523-2695): 4.09e-15: 85.6: 22.60
+	Hs
		932950 FKB1B_HUMAN (1-108): 2.61e-52: 161: 83.33		RYR2_HUMAN (2523-2695): 4.09e-15: 85.6: 22.60
+	Mm
		93493 FKB1B_MOUSE (1-108): 3.25e-51: 158: 82.41		RYR2_MOUSE (2523-2687): 1.33e-14: 84: 22.89