Protein: TMED2
Transmembrane emp24 domain-containing protein 2 (Membrane protein p24A) (p24) (p24 family protein beta-1) (p24beta1)

Gene: TMED2
Organism: Homo sapiens
Interactions: 233
UniProt ID: Q15363

Gene Ontology (top 5):
GO:0000139 - Golgi membrane
GO:0001843 - neural tube closure
GO:0001893 - maternal placenta development
GO:0001947 - heart looping
GO:0005109 - frizzled binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

888874

TMEDA
Transmembrane emp24 domain-containing protein 10

10

17

Small-scale

0.968

High

1146568

TMED4
Transmembrane emp24 domain-containing protein 4

5

17

High-throughput

0.925

High

1146663

TMED7
Transmembrane emp24 domain-containing protein 7

5

18

Small-scale

0.916

High

1105843

TMED1
Transmembrane emp24 domain-containing protein 1

4

18

High-throughput

0.900

High

1146662

TMED5
Transmembrane emp24 domain-containing protein 5

4

18

High-throughput

0.900

High

1146664

TMED3
Transmembrane emp24 domain-containing protein 3

4

18

High-throughput

0.892

High

1146621

TMED9
Transmembrane emp24 domain-containing protein 9

4

18

Small-scale

0.887

High

1146634

CHST8
Carbohydrate sulfotransferase 8

4

6

High-throughput

0.691

High

1146638

GORS2
Golgi reassembly-stacking protein 2

3

16

Small-scale

0.683

High

1146579

EMC1
ER membrane protein complex subunit 1

4

4

High-throughput

0.678

High

1132260

GOGB1
Golgin subfamily B member 1

3

3

High-throughput

0.662

High

1023428

AT8B2
Phospholipid-transporting ATPase ID

2

3

High-throughput

0.628

High

1146575

FGRL1
Fibroblast growth factor receptor-like 1

2

3

High-throughput

0.628

High

1146626

OSBL6
Oxysterol-binding protein-related protein 6

2

4

High-throughput

0.628

High

1146658

PA2G4
Proliferation-associated protein 2G4

2

2

High-throughput

0.628

High

1146665

LIPG
Endothelial lipase

2

5

High-throughput

0.628

High

1146545

TMED2
Transmembrane emp24 domain-containing protein 2

1

18

Small-scale

0.618

High

184443

SURF4
Surfeit locus protein 4

2

4

Small-scale

0.612

High

229720

CALU
Calumenin

2

4

High-throughput

0.611

High

1063265

GOGA2
Golgin subfamily A member 2

2

5

Small-scale

0.611

High

936052

PAR2
Proteinase-activated receptor 2

2

7

Small-scale

0.608

High

270641

ATP9A
Probable phospholipid-transporting ATPase IIA

3

3

High-throughput

0.604

High

1146588

PNPT1
Polyribonucleotide nucleotidyltransferase 1, mitochondrial

2

0

High-throughput

0.602

High

1146630

MAGT1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit MAGT1

2

6

High-throughput

0.601

High

1146643

EMC7
Endoplasmic reticulum membrane protein complex subunit 7

2

4

High-throughput

0.601

High

1146608

CALR3
Calreticulin-3

2

9

High-throughput

0.584

High

2045

A0A0A6YYA0
Transmembrane emp24 domain-containing protein 7

1

18

High-throughput

0.575

High

931238

AT12A
Potassium-transporting ATPase alpha chain 2

2

5

High-throughput

0.574

High

1146609

DJC30
DnaJ homolog subfamily C member 30, mitochondrial

2

5

High-throughput

0.574

High

1146614

GORS1
Golgi reassembly-stacking protein 1

1

15

Small-scale

0.573

High

396160

ESR1
Estrogen receptor

2

11

High-throughput

0.571

High

535091

BIP
Endoplasmic reticulum chaperone BiP

2

6

High-throughput

0.571

High

631237

RAB5A
Ras-related protein Rab-5A

2

10

High-throughput

0.571

High

1136207

EMC2
ER membrane protein complex subunit 2

2

4

High-throughput

0.571

High

1146591

ATLA1
Atlastin-1

2

8

Small-scale

0.571

High

1146652

VAPA
Vesicle-associated membrane protein-associated protein A

2

10

High-throughput

0.571

High

130110

PGRC1
Membrane-associated progesterone receptor component 1

1

5

High-throughput

0.536

High

219304

B4GA1
Beta-1,4-glucuronyltransferase 1

1

2

High-throughput

0.536

High

249245

MA1A2
Mannosyl-oligosaccharide 1,2-alpha-mannosidase IB

1

3

High-throughput

0.536

High

261177

NSMA
Sphingomyelin phosphodiesterase 2

1

2

High-throughput

0.536

High

280209

SC22B
Vesicle-trafficking protein SEC22b

1

4

High-throughput

0.536

High

562795

CY24A
Cytochrome b-245 light chain

1

1

High-throughput

0.536

High

698681

CALX
Calnexin

1

9

High-throughput

0.536

High

755396

MA1A1
Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA

1

3

High-throughput

0.536

High

762129

CNR2
Cannabinoid receptor 2

1

5

Small-scale

0.536

High

921905

COPA
Coatomer subunit alpha

1

11

High-throughput

0.536

High

952497

CTXN1
Cortexin-1

1

1

High-throughput

0.536

High

956300

RAB2A
Ras-related protein Rab-2A

1

10

High-throughput

0.536

High

981283

RAB1A
Ras-related protein Rab-1A

1

7

High-throughput

0.536

High

1083103

GALT2
Polypeptide N-acetylgalactosaminyltransferase 2

1

2

High-throughput

0.536

High

1089952

LMAN2
Vesicular integral-membrane protein VIP36

1

3

High-throughput

0.536

High

1145573

RCN1
Reticulocalbin-1

1

4

High-throughput

0.536

High

1146554

RABL3
Rab-like protein 3

1

7

High-throughput

0.536

High

1146555

STEA3
Metalloreductase STEAP3

1

1

High-throughput

0.536

High

1146556

GL8D1
Glycosyltransferase 8 domain-containing protein 1

1

1

High-throughput

0.536

High

1146589

SPP2B
Signal peptide peptidase-like 2B

1

6

High-throughput

0.536

High

1146590

SCFD1
Sec1 family domain-containing protein 1

1

2

High-throughput

0.536

High

1146595

YIPF5
Protein YIPF5

1

5

High-throughput

0.536

High

1146597

CCD47
PAT complex subunit CCDC47

1

2

High-throughput

0.536

High

1146606

CK5P3
CDK5 regulatory subunit-associated protein 3

1

5

High-throughput

0.536

High

1146611

ERGI2
Endoplasmic reticulum-Golgi intermediate compartment protein 2

1

10

High-throughput

0.536

High

1146613

MBB1A
Myb-binding protein 1A

1

4

High-throughput

0.536

High

1146617

ERP44
Endoplasmic reticulum resident protein 44

1

5

High-throughput

0.536

High

1146631

RAB1B
Ras-related protein Rab-1B

1

6

High-throughput

0.536

High

1146632

LMA2L
VIP36-like protein

1

2

High-throughput

0.536

High

1146636

TMX1
Thioredoxin-related transmembrane protein 1

1

9

High-throughput

0.536

High

1146637

SG196
Protein O-mannose kinase

1

1

High-throughput

0.536

High

1146642

RAB18
Ras-related protein Rab-18

1

9

High-throughput

0.536

High

1146659

ERGI3
Endoplasmic reticulum-Golgi intermediate compartment protein 3

1

10

High-throughput

0.536

High

1146668

SAR1B
Small COPII coat GTPase SAR1B

1

13

High-throughput

0.536

High

1146570

ZDH13
Palmitoyltransferase ZDHHC13

1

0

High-throughput

0.513

High

832607

CASR
Extracellular calcium-sensing receptor

1

2

Small-scale

0.506

High

569189

CD59
CD59 glycoprotein

1

0

Small-scale

0.493

High

251765

BUB1B
Mitotic checkpoint serine/threonine-protein kinase BUB1 beta

1

2

High-throughput

0.489

High

546975

FGF3
Fibroblast growth factor 3

1

7

High-throughput

0.489

High

1146572

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

2

High-throughput

0.489

High

1146619

DIDO1
Death-inducer obliterator 1

1

2

High-throughput

0.489

High

1146656

HERC5
E3 ISG15--protein ligase HERC5

1

3

High-throughput

0.489

High

157408

CTRO
Citron Rho-interacting kinase

1

1

High-throughput

0.479

High

218210

TGON2
Trans-Golgi network integral membrane protein 2

1

7

High-throughput

0.479

High

315611

RECQ4
ATP-dependent DNA helicase Q4

1

3

High-throughput

0.479

High

319098

SC24D
Protein transport protein Sec24D

1

16

Small-scale

0.479

High

338331

SC24A
Protein transport protein Sec24A

1

16

Small-scale

0.479

High

338475

SC24B
Protein transport protein Sec24B

1

16

Small-scale

0.479

High

353346

AGR2
Anterior gradient protein 2 homolog

1

1

High-throughput

0.479

High

404070

GCR
Glucocorticoid receptor

1

11

High-throughput

0.479

High

537198

HSP7C
Heat shock cognate 71 kDa protein

1

2

High-throughput

0.479

High

543210

UBL4A
Ubiquitin-like protein 4A

1

7

High-throughput

0.479

High

566682

PDIA4
Protein disulfide-isomerase A4

1

2

High-throughput

0.479

High

669388

PAR1
Proteinase-activated receptor 1

1

7

Small-scale

0.479

High

925718

SC24C
Protein transport protein Sec24C

1

16

Small-scale

0.479

High

951166

SC61B
Protein transport protein Sec61 subunit beta

1

2

High-throughput

0.479

High

1146547

SC23A
Protein transport protein Sec23A

1

16

Small-scale

0.479

High

1146550

PTPRO
Receptor-type tyrosine-protein phosphatase O

1

1

High-throughput

0.479

High

1146551

TECT1
Tectonic-1

1

5

High-throughput

0.479

High

1146564

SYNE3
Nesprin-3

1

2

High-throughput

0.479

High

1146566

CE128
Centrosomal protein of 128 kDa

1

1

High-throughput

0.479

High

1146576

EMC5
ER membrane protein complex subunit 5

1

2

High-throughput

0.479

High

1146593

ESR2
Estrogen receptor beta

1

11

High-throughput

0.479

High

1146598

LRC59
Leucine-rich repeat-containing protein 59

1

2

High-throughput

0.479

High

1146601

FAF2
FAS-associated factor 2

1

2

High-throughput

0.479

High

1146605

DDRGK
DDRGK domain-containing protein 1

1

5

High-throughput

0.479

High

1146633

DJC25
DnaJ homolog subfamily C member 25

1

4

High-throughput

0.479

High

1146640

NOD2
Nucleotide-binding oligomerization domain-containing protein 2

1

9

High-throughput

0.479

High

1146655

ZRAN1
Ubiquitin thioesterase ZRANB1

1

3

High-throughput

0.479

High

728590

AKT2
RAC-beta serine/threonine-protein kinase

1

0

High-throughput

0.460

High

1146581

SERB1
SERPINE1 mRNA-binding protein 1

1

0

High-throughput

0.458

High

1146615

OVOL2
Transcription factor Ovo-like 2

1

0

Small-scale

0.458

High

339754

KLF8
Krueppel-like factor 8

1

5

High-throughput

0.457

High

1146622

KLF16
Krueppel-like factor 16

1

4

High-throughput

0.457

High

48634

ESYT2
Extended synaptotagmin-2

1

5

High-throughput

0.445

High

50560

HACL2
2-hydroxyacyl-CoA lyase 2

1

2

High-throughput

0.445

High

60346

NBAS
NBAS subunit of NRZ tethering complex

1

2

High-throughput

0.445

High

104341

F5H6I7
Atlastin GTPase 3

1

8

High-throughput

0.445

High

158214

COPE
Coatomer subunit epsilon

1

2

High-throughput

0.445

High

211792

ZW10
Centromere/kinetochore protein zw10 homolog

1

2

High-throughput

0.445

High

215568

EMC8
ER membrane protein complex subunit 8

1

2

High-throughput

0.445

High

256035

S19A2
Thiamine transporter 1

1

4

High-throughput

0.445

High

275518

RTN2
Reticulon-2

1

8

High-throughput

0.445

High

283257

ERLN1
Erlin-1

1

2

High-throughput

0.445

High

296502

STAM2
Signal transducing adapter molecule 2

1

4

High-throughput

0.445

High

318985

MICA2
[F-actin]-monooxygenase MICAL2

1

2

High-throughput

0.445

High

328923

RTN3
Reticulon-3

1

8

High-throughput

0.445

High

333015

VAPB
Vesicle-associated membrane protein-associated protein B/C

1

10

High-throughput

0.445

High

359993

NB5R3
NADH-cytochrome b5 reductase 3

1

3

High-throughput

0.445

High

462428

HNRPC
Heterogeneous nuclear ribonucleoproteins C1/C2

1

2

High-throughput

0.445

High

518601

RAP2A
Ras-related protein Rap-2a

1

9

High-throughput

0.445

High

566986

P4HA1
Prolyl 4-hydroxylase subunit alpha-1

1

2

High-throughput

0.445

High

697888

CALR
Calreticulin

1

9

High-throughput

0.445

High

722460

CTR1
High affinity cationic amino acid transporter 1

1

12

High-throughput

0.445

High

773514

COPB2
Coatomer subunit beta'

1

11

High-throughput

0.445

High

870235

S6A12
Sodium- and chloride-dependent betaine transporter

1

3

High-throughput

0.445

High

870360

S6A11
Sodium- and chloride-dependent GABA transporter 3

1

3

High-throughput

0.445

High

873231

COPD
Coatomer subunit delta

1

4

High-throughput

0.445

High

876868

KC1A
Casein kinase I isoform alpha

1

4

High-throughput

0.445

High

903703

SSRD
Translocon-associated protein subunit delta

1

2

High-throughput

0.445

High

903922

BAP31
B-cell receptor-associated protein 31

1

4

High-throughput

0.445

High

921677

COPB
Coatomer subunit beta

1

3

High-throughput

0.445

High

964007

COPZ1
Coatomer subunit zeta-1

1

3

High-throughput

0.445

High

987039

RS27A
Ubiquitin-ribosomal protein eS31 fusion protein

1

2

High-throughput

0.445

High

1007437

S35B1
Solute carrier family 35 member B1

1

5

High-throughput

0.445

High

1009837

NUCB2
Nucleobindin-2

1

2

High-throughput

0.445

High

1015026

ARF5
ADP-ribosylation factor 5

1

11

High-throughput

0.445

High

1027012

REEP5
Receptor expression-enhancing protein 5

1

2

High-throughput

0.445

High

1085425

SRBP2
Sterol regulatory element-binding protein 2

1

4

High-throughput

0.445

High

1096967

PRDX4
Peroxiredoxin-4

1

2

High-throughput

0.445

High

1131265

GANAB
Neutral alpha-glucosidase AB

1

2

High-throughput

0.445

High

1131534

MFS10
Major facilitator superfamily domain-containing protein 10

1

3

High-throughput

0.445

High

1139197

AR6P1
ADP-ribosylation factor-like protein 6-interacting protein 1

1

2

High-throughput

0.445

High

1139315

RB3GP
Rab3 GTPase-activating protein catalytic subunit

1

2

High-throughput

0.445

High

1139431

S39AE
Metal cation symporter ZIP14

1

7

High-throughput

0.445

High

1140307

KIF14
Kinesin-like protein KIF14

1

7

High-throughput

0.445

High

1146546

DHC24
Delta(24)-sterol reductase

1

2

High-throughput

0.445

High

1146549

NSDHL
Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating

1

3

High-throughput

0.445

High

1146552

DHB12
Very-long-chain 3-oxoacyl-CoA reductase

1

10

High-throughput

0.445

High

1146553

YIF1B
Protein YIF1B

1

3

High-throughput

0.445

High

1146558

MFSD5
Molybdate-anion transporter

1

7

High-throughput

0.445

High

1146561

NPAL3
NIPA-like protein 3

1

8

High-throughput

0.445

High

1146562

LCLT1
Lysocardiolipin acyltransferase 1

1

2

High-throughput

0.445

High

1146563

ZNT10
Calcium/manganese antiporter SLC30A10

1

12

High-throughput

0.445

High

1146569

TCAM2
TIR domain-containing adapter molecule 2

1

2

High-throughput

0.445

High

1146571

FMNL3
Formin-like protein 3

1

1

High-throughput

0.445

High

1146573

PACE1
Protein-associating with the carboxyl-terminal domain of ezrin

1

5

High-throughput

0.445

High

1146574

S39AB
Zinc transporter ZIP11

1

7

High-throughput

0.445

High

1146578

CISD2
CDGSH iron-sulfur domain-containing protein 2

1

2

High-throughput

0.445

High

1146580

DHB11
Estradiol 17-beta-dehydrogenase 11

1

8

High-throughput

0.445

High

1146582

CTL5
Choline transporter-like protein 5

1

1

High-throughput

0.445

High

1146583

PDZD8
PDZ domain-containing protein 8

1

2

High-throughput

0.445

High

1146584

VP37A
Vacuolar protein sorting-associated protein 37A

1

2

High-throughput

0.445

High

1146585

ATLA2
Atlastin-2

1

8

High-throughput

0.445

High

1146586

MCFD2
Multiple coagulation factor deficiency protein 2

1

2

High-throughput

0.445

High

1146592

TSC1
Hamartin

1

4

High-throughput

0.445

High

1146596

ERGI1
Endoplasmic reticulum-Golgi intermediate compartment protein 1

1

10

High-throughput

0.445

High

1146600

ASTRA
Protein Aster-A

1

2

High-throughput

0.445

High

1146607

SCYL1
N-terminal kinase-like protein

1

5

High-throughput

0.445

High

1146618

ESYT1
Extended synaptotagmin-1

1

5

High-throughput

0.445

High

1146620

NDC1
Nucleoporin NDC1

1

2

High-throughput

0.445

High

1146623

S12A9
Solute carrier family 12 member 9

1

12

High-throughput

0.445

High

1146627

WDR11
WD repeat-containing protein 11

1

2

High-throughput

0.445

High

1146628

LNP
Endoplasmic reticulum junction formation protein lunapark

1

3

High-throughput

0.445

High

1146635

RBGPR
Rab3 GTPase-activating protein non-catalytic subunit

1

2

High-throughput

0.445

High

1146641

APMAP
Adipocyte plasma membrane-associated protein

1

2

High-throughput

0.445

High

1146644

RTN4
Reticulon-4

1

8

High-throughput

0.445

High

1146646

SAC1
Phosphatidylinositol-3-phosphatase SAC1

1

2

High-throughput

0.445

High

1146648

TM38B
Trimeric intracellular cation channel type B

1

2

High-throughput

0.445

High

1146651

TECR
Very-long-chain enoyl-CoA reductase

1

3

High-throughput

0.445

High

1146653

COPG2
Coatomer subunit gamma-2

1

7

High-throughput

0.445

High

1146661

DHRS7
Dehydrogenase/reductase SDR family member 7

1

5

High-throughput

0.445

High

1146667

COPG1
Coatomer subunit gamma-1

1

7

High-throughput

0.445

High

223064

PRC1
Protein regulator of cytokinesis 1

1

1

High-throughput

0.437

High

588760

RFA2
Replication protein A 32 kDa subunit

1

4

High-throughput

0.437

High

695525

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

4

High-throughput

0.437

High

904257

P2RY4
P2Y purinoceptor 4

1

8

Small-scale

0.437

High

947193

NLRP6
NACHT, LRR and PYD domains-containing protein 6

1

9

High-throughput

0.437

High

1117274

APR
Phorbol-12-myristate-13-acetate-induced protein 1

1

2

High-throughput

0.437

High

1126085

GRM2
Metabotropic glutamate receptor 2

1

2

High-throughput

0.437

High

1146557

VIR
Protein virilizer homolog

1

4

High-throughput

0.437

High

1146560

TECT3
Tectonic-3

1

5

High-throughput

0.437

High

1146565

TRI67
Tripartite motif-containing protein 67

1

7

High-throughput

0.437

High

1146577

FBXL6
F-box/LRR-repeat protein 6

1

2

High-throughput

0.437

High

1146587

LNX1
E3 ubiquitin-protein ligase LNX

1

4

Small-scale

0.437

High

1146604

P2Y11
P2Y purinoceptor 11

1

9

Small-scale

0.437

High

1146624

FACD2
Fanconi anemia group D2 protein

1

3

High-throughput

0.437

High

1146647

T106B
Transmembrane protein 106B

1

4

High-throughput

0.437

High

1146559

TM214
Transmembrane protein 214

1

0

High-throughput

0.426

High

1146660

EXC6B
Exocyst complex component 6B

1

0

High-throughput

0.426

High

1146548

SC23B
Protein transport protein Sec23B

1

16

Small-scale

0.408

High

213608

VIP2
Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2

1

2

High-throughput

0.407

High

529842

TAU
Microtubule-associated protein tau

1

5

High-throughput

0.407

High

883100

AL7A1
Alpha-aminoadipic semialdehyde dehydrogenase

1

2

High-throughput

0.407

High

1146567

UB2R2
Ubiquitin-conjugating enzyme E2 R2

1

3

High-throughput

0.407

High

1146599

RUSD4
Pseudouridylate synthase RPUSD4, mitochondrial

1

2

High-throughput

0.407

High

1146602

SAAL1
Protein SAAL1

1

3

High-throughput

0.407

High

1146610

FMNL2
Formin-like protein 2

1

1

High-throughput

0.407

High

1146612

NUDC1
NudC domain-containing protein 1

1

2

High-throughput

0.407

High

1146616

PXL2A
Peroxiredoxin-like 2A

1

2

High-throughput

0.407

High

1146625

GNB1L
Guanine nucleotide-binding protein subunit beta-like protein 1

1

7

High-throughput

0.407

High

1146629

RGAP1
Rac GTPase-activating protein 1

1

2

High-throughput

0.407

High

1146645

DUS22
Dual specificity protein phosphatase 22

1

2

High-throughput

0.407

High

1146649

GPTC2
G patch domain-containing protein 2

1

2

High-throughput

0.407

High

1146650

PSD3
PH and SEC7 domain-containing protein 3

1

2

High-throughput

0.407

High

1146654

S53A1
Solute carrier family 53 member 1

1

2

High-throughput

0.407

High

1146666

SERC
Phosphoserine aminotransferase

1

2

High-throughput

0.407

High

1146657

UBP22
Ubiquitin carboxyl-terminal hydrolase 22

2

0

High-throughput

0.328

High

353939

NDUBA
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10

1

0

High-throughput

0.279

Low

462779

QCR6
Cytochrome b-c1 complex subunit 6, mitochondrial

1

0

High-throughput

0.279

Low

1146639

MED20
Mediator of RNA polymerase II transcription subunit 20

1

0

High-throughput

0.279

Low

830782

CCNF
Cyclin-F

1

0

High-throughput

0.249

Low

281518

LRCH4
Leucine-rich repeat and calponin homology domain-containing protein 4

1

0

High-throughput

0.232

Low

292836

GRAP2
GRB2-related adapter protein 2

1

0

High-throughput

0.232

Low

1146594

HTRA1
Serine protease HTRA1

1

0

High-throughput

0.232

Low

1146603

NRBF2
Nuclear receptor-binding factor 2

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025