HitPredict

Interactor 1: RL40 (P62987)
Ubiquitin-ribosomal protein eL40 fusion protein (CEP52) (Ubiquitin A-52 residue ribosomal protein fusion product 1) [Cleaved into: Ubiquitin; Large ribosomal subunit protein eL40 (60S ribosomal protein L40)]
Gene: UBA52

Interactor 2: SMUF2 (Q9HAU4)
E3 ubiquitin-protein ligase SMURF2 (hSMURF2) (EC 2.3.2.26) (HECT-type E3 ubiquitin transferase SMURF2) (SMAD ubiquitination regulatory factor 2) (SMAD-specific E3 ubiquitin-protein ligase 2)
Gene: SMURF2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	23973329
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	HECT~ubiquitin
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane and 1 others more... GO:0016567 - protein ubiquitination
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 128 Hs			1 748
+	Hs
		475196 UBB_HUMAN (1-76): 1.52e-33: 118: 100.00		SMUF2_HUMAN (1-748): 0: 834: 100.00
+	Sp
		145418 RL402_SCHPO (1-128): 3.96e-53: 164: 90.63		PUB3_SCHPO (10-748): 0: 669: 34.64
+	Sp
		145416 RS27A_SCHPO (1-71): 1.27e-32: 113: 95.78		PUB3_SCHPO (10-748): 0: 669: 34.64
+	Sp
		145417 RS27B_SCHPO (1-71): 1.02e-32: 113: 95.78		PUB3_SCHPO (10-748): 0: 669: 34.64
+	Hs
		924336 RL40_HUMAN (1-128): 1.05e-56: 174: 100.00		HUWE1_HUMAN (114-747): 0: 589: 31.46
+	Hs
		474953 UBB_HUMAN (1-76): 1.52e-33: 118: 100.00		NEDD4_HUMAN (104-746): 0: 628: 38.73
+	Mm
		924239 RS27A_MOUSE (1-77): 2.38e-38: 128: 98.70		HUWE1_MOUSE (152-747): 0: 584: 33.28
+	Hs
		475080 UBB_HUMAN (1-76): 1.52e-33: 118: 100.00		HUWE1_HUMAN (114-747): 0: 589: 31.46
+	Sc
		477647 RL40A_YEAST (1-128): 1.32e-53: 166: 89.84		TOM1_YEAST (325-747): 1.36e-156: 505: 40.47
+	Dm
		89880 RL40_DROME (1-128): 2.2e-56: 173: 97.66		D5SHR3_DROME (343-748): 2.37e-165: 485: 42.48
+	At
		1091762 UBQ3_ARATH (1-78): 1.98e-32: 117: 93.59		UPL2_ARATH (96-746): 1.46e-168: 540: 29.26
+	At
		1091758 UBQ3_ARATH (1-78): 1.98e-32: 117: 93.59		UPL1_ARATH (96-746): 1.48e-166: 534: 29.26
+	Dm
		1376481 Q9W418_DROME (1-77): 1.45e-41: 145: 98.70		Q9W325_DROME (343-748): 8.33e-164: 481: 42.48
+	Hs
		125347 RS27A_HUMAN (1-77): 2.11e-38: 128: 98.70		WWP2_HUMAN (1-416): 7.64e-26: 116: 17.39
+	Hs
		125112 UBB_HUMAN (1-76): 1.52e-33: 118: 100.00		WWP2_HUMAN (1-416): 7.64e-26: 116: 17.39
+	Hs
		924156 RS27A_HUMAN (1-77): 2.11e-38: 128: 98.70		WWP1_HUMAN (2-395): 4.38e-20: 97.5: 15.47
+	Hs
		475140 UBB_HUMAN (1-76): 1.52e-33: 118: 100.00		ITCH_HUMAN (1-426): 2.45e-23: 107: 16.44