HitPredict

Interactor 1: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Interactor 2: KHDR1 (Q07666)
KH domain-containing, RNA-binding, signal transduction-associated protein 1 (GAP-associated tyrosine phosphoprotein p62) (Src-associated in mitosis 68 kDa protein) (Sam68) (p21 Ras GTPase-activating protein-associated p62) (p68)
Gene: KHDRBS1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.94	0.60	0.755

Property	Details
Experiments	10467411, 22745667, 9872323, 11960376, 20936779, 21706016, 21988832, 9045636, 7537265, 11278465
Identification Methods	pull down, affinity chromatography technology, unspecified method, two hybrid, coimmunoprecipitation, two hybrid pooling approach, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol and 1 others more... GO:0017124 - SH3 domain binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 217 Hs			1 443
+	Mm
		1141126 GRB2_MOUSE (1-217): 2.48e-76: 230: 99.54		KHDR1_MOUSE (1-443): 0: 514: 94.36
+	Hs
		411689 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		KHDR1_HUMAN (1-443): 3.7e-177: 504: 100.00
+	Mm
		1141333 NCK1_MOUSE (5-145): 8.99e-23: 96.3: 33.14		KHDR1_MOUSE (1-443): 0: 514: 94.36
+	Hs
		782780 CSK_HUMAN (2-139): 3.92e-24: 100: 36.24		KHDR1_HUMAN (1-443): 3.7e-177: 504: 100.00
+	Hs
		991758 PTK6_HUMAN (4-141): 7.14e-23: 97.1: 38.93		KHDR1_HUMAN (1-443): 3.7e-177: 504: 100.00
+	Hs
		557667 NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14		KHDR1_HUMAN (1-443): 3.7e-177: 504: 100.00
+	Mm
		1141173 GRB2_MOUSE (1-217): 2.48e-76: 230: 99.54		KHDR2_MOUSE (100-443): 8.36e-126: 370: 61.65
+	Mm
		763394 FYN_MOUSE (161-215): 4.44e-14: 72.3: 31.58		KHDR1_MOUSE (1-443): 0: 514: 94.36
+	Mm
		980964 YES_MOUSE (161-215): 4.35e-12: 66.5: 28.07		KHDR1_MOUSE (1-443): 0: 514: 94.36
+	Hs
		991902 ITSN2_HUMAN (2-61): 5.91e-15: 75: 36.67		KHDR1_HUMAN (1-443): 3.7e-177: 504: 100.00
+	Hs
		548692 VAV_HUMAN (2-60): 8.95e-15: 74.6: 42.37		KHDR1_HUMAN (1-443): 3.7e-177: 504: 100.00
+	Hs
		412149 FYN_HUMAN (161-215): 4.44e-14: 72.3: 31.58		KHDR1_HUMAN (1-443): 3.7e-177: 504: 100.00
+	Hs
		433330 YES_HUMAN (59-215): 4.17e-13: 69.2: 14.91		KHDR1_HUMAN (1-443): 3.7e-177: 504: 100.00
+	Hs
		454827 FGR_HUMAN (120-215): 6.83e-13: 68.8: 22.45		KHDR1_HUMAN (1-443): 3.7e-177: 504: 100.00
+	Hs
		442815 HCK_HUMAN (120-215): 1.21e-12: 68.1: 19.39		KHDR1_HUMAN (1-443): 3.7e-177: 504: 100.00
+	Hs
		991778 ITSN1_HUMAN (137-216): 1.36e-12: 68.1: 25.00		KHDR1_HUMAN (1-443): 3.7e-177: 504: 100.00
+	Hs
		1046410 PTK6_HUMAN (4-141): 7.14e-23: 97.1: 38.93		KHDR2_HUMAN (99-443): 5.18e-130: 381: 60.62
+	Mm
		763412 FYN_MOUSE (161-215): 4.44e-14: 72.3: 31.58		KHDR2_MOUSE (100-443): 8.36e-126: 370: 61.65
+	Hs
		337484 ABL1_HUMAN (4-139): 4.39e-22: 95.5: 35.46		SF01_HUMAN (82-301): 6.63e-54: 192: 21.33
+	Hs
		789069 ABL2_HUMAN (4-139): 9.61e-22: 94.7: 34.04		SF01_HUMAN (82-301): 6.63e-54: 192: 21.33