Protein: PFD4
Prefoldin subunit 4 (Protein C-1)

Gene: PFD4, PFDN4
Organism: Homo sapiens
Interactions: 107
UniProt ID: Q9NQP4

Gene Ontology (top 5):
GO:0001540 - amyloid-beta binding
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0005739 - mitochondrion
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

963376

PFD3
Prefoldin subunit 3

8

2

High-throughput

0.971

High

182190

PFD6
Prefoldin subunit 6

6

2

High-throughput

0.945

High

261880

PFD1
Prefoldin subunit 1

4

1

High-throughput

0.892

High

1404676

PFD5
Prefoldin subunit 5

4

2

High-throughput

0.892

High

1447147

PFD2
Prefoldin subunit 2

4

2

High-throughput

0.892

High

1447141

PDRG1
p53 and DNA damage-regulated protein 1

3

0

High-throughput

0.811

High

316448

RMP
Unconventional prefoldin RPB5 interactor 1

1

3

High-throughput

0.691

High

964749

DCAF7
DDB1- and CUL4-associated factor 7

4

3

High-throughput

0.691

High

1097167

MK07
Mitogen-activated protein kinase 7

4

1

High-throughput

0.691

High

1363092

DDB2
DNA damage-binding protein 2

4

6

High-throughput

0.691

High

984294

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

3

4

High-throughput

0.667

High

1098378

ERCC8
DNA excision repair protein ERCC-8

3

5

Small-scale

0.667

High

1395147

DCAF5
DDB1- and CUL4-associated factor 5

3

5

High-throughput

0.667

High

1415093

KTNB1
Katanin p80 WD40 repeat-containing subunit B1

3

4

High-throughput

0.667

High

1180700

CTU2
Cytoplasmic tRNA 2-thiolation protein 2

2

1

High-throughput

0.628

High

1207314

SPIN3
Spindlin-3

2

1

High-throughput

0.628

High

1246165

TRAF7
E3 ubiquitin-protein ligase TRAF7

2

5

High-throughput

0.628

High

1340675

NEDD1
Protein NEDD1

2

6

High-throughput

0.628

High

1409752

SPI2B
Spindlin-2B

2

1

High-throughput

0.628

High

1428696

SKI8
Superkiller complex protein 8

2

5

High-throughput

0.628

High

882177

TCPG
T-complex protein 1 subunit gamma

1

2

High-throughput

0.618

High

899251

TCPQ
T-complex protein 1 subunit theta

1

3

High-throughput

0.618

High

899601

TCPD
T-complex protein 1 subunit delta

1

3

High-throughput

0.618

High

1407586

TCPH
T-complex protein 1 subunit eta

1

2

High-throughput

0.618

High

282492

KTNA1
Katanin p60 ATPase-containing subunit A1

2

0

High-throughput

0.602

High

507382

UBB
Polyubiquitin-B [Cleaved into: Ubiquitin]

2

0

High-throughput

0.602

High

1429323

MFR1L
Mitochondrial fission regulator 1-like

2

0

High-throughput

0.602

High

1447143

MIOS
GATOR2 complex protein MIOS

2

0

High-throughput

0.602

High

1447145

UXT
Protein UXT

1

0

Small-scale

0.586

High

1408294

DUS9
Dual specificity protein phosphatase 9

2

1

High-throughput

0.584

High

1447148

FBW1B
F-box/WD repeat-containing protein 11

2

6

High-throughput

0.584

High

290399

RFPL3
Ret finger protein-like 3

2

0

High-throughput

0.580

High

1316082

RUSD2
Pseudouridylate synthase RPUSD2

2

1

High-throughput

0.574

High

1110107

HDAC1
Histone deacetylase 1

2

0

High-throughput

0.547

High

209339

PRP4
U4/U6 small nuclear ribonucleoprotein Prp4

1

4

High-throughput

0.536

High

583609

ATF2
Cyclic AMP-dependent transcription factor ATF-2

1

1

High-throughput

0.536

High

996865

TBA1B
Tubulin alpha-1B chain

1

3

High-throughput

0.536

High

1094818

CAF1B
Chromatin assembly factor 1 subunit B

1

4

High-throughput

0.536

High

1347601

UHMK1
Serine/threonine-protein kinase Kist

1

1

High-throughput

0.536

High

1447146

AAKG3
5'-AMP-activated protein kinase subunit gamma-3

1

1

High-throughput

0.536

High

1244143

TBA3E
Tubulin alpha-3E chain

1

2

High-throughput

0.515

High

67712

RHG32
Rho GTPase-activating protein 32

1

0

High-throughput

0.513

High

593226

CREB1
Cyclic AMP-responsive element-binding protein 1

1

0

High-throughput

0.513

High

997528

TBB4B
Tubulin beta-4B chain

1

0

High-throughput

0.513

High

1163765

PTN21
Tyrosine-protein phosphatase non-receptor type 21

1

0

High-throughput

0.513

High

1185952

PCGF3
Polycomb group RING finger protein 3

1

0

High-throughput

0.513

High

1187756

KR133
Keratin-associated protein 13-3

1

0

High-throughput

0.513

High

1286802

KAISO
Transcriptional regulator Kaiso

1

0

High-throughput

0.513

High

1332050

BANP
Protein BANP

1

0

High-throughput

0.513

High

1369492

TANK
TRAF family member-associated NF-kappa-B activator

1

0

High-throughput

0.513

High

1405335

PI3R4
Phosphoinositide 3-kinase regulatory subunit 4

1

0

High-throughput

0.513

High

1447151

SPAT2
Spermatogenesis-associated protein 2

1

0

High-throughput

0.513

High

156082

SOCS6
Suppressor of cytokine signaling 6

1

0

High-throughput

0.493

High

1287304

WDR86
WD repeat-containing protein 86

1

8

High-throughput

0.489

High

156670

DC1I1
Cytoplasmic dynein 1 intermediate chain 1

1

4

High-throughput

0.479

High

607133

CEBPB
CCAAT/enhancer-binding protein beta

1

1

High-throughput

0.479

High

965263

WDR5
WD repeat-containing protein 5

1

3

High-throughput

0.479

High

1104266

DC1I2
Cytoplasmic dynein 1 intermediate chain 2

1

4

High-throughput

0.479

High

1149470

SKI2
Superkiller complex protein 2

1

2

High-throughput

0.479

High

1202248

DCAF6
DDB1- and CUL4-associated factor 6

1

6

High-throughput

0.479

High

1213477

DCA12
DDB1- and CUL4-associated factor 12

1

1

High-throughput

0.479

High

1259526

TBA1A
Tubulin alpha-1A chain

1

3

High-throughput

0.479

High

1327605

WDTC1
WD and tetratricopeptide repeats protein 1

1

5

High-throughput

0.479

High

1334180

POC1A
POC1 centriolar protein homolog A

1

5

High-throughput

0.479

High

1349436

POC1B
POC1 centriolar protein homolog B

1

5

High-throughput

0.479

High

1355902

DUS19
Dual specificity protein phosphatase 19

1

1

High-throughput

0.479

High

1383866

EFMT3
EEF1A lysine methyltransferase 3

1

1

High-throughput

0.479

High

1447149

FZR1
Fizzy-related protein homolog

1

3

High-throughput

0.479

High

1447153

FBW1A
F-box/WD repeat-containing protein 1A

1

6

High-throughput

0.479

High

289180

PRDM1
PR domain zinc finger protein 1

1

0

High-throughput

0.458

High

373232

MYC
Myc proto-oncogene protein

1

0

High-throughput

0.458

High

517556

GLI3
Transcriptional activator GLI3

1

0

High-throughput

0.458

High

822875

VHL
von Hippel-Lindau disease tumor suppressor

1

0

Small-scale

0.458

High

837099

ELK3
ETS domain-containing protein Elk-3

1

0

High-throughput

0.458

High

995834

ACTC
Actin, alpha cardiac muscle 1

1

0

High-throughput

0.458

High

1091256

FOXI1
Forkhead box protein I1

1

0

High-throughput

0.458

High

1101043

G3BP1
Ras GTPase-activating protein-binding protein 1

1

0

High-throughput

0.458

High

1149381

STIL
SCL-interrupting locus protein

1

0

High-throughput

0.458

High

1240705

CDC73
Parafibromin

1

0

High-throughput

0.458

High

1244377

SKI3
Superkiller complex protein 3

1

0

High-throughput

0.458

High

1255675

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.458

High

1274053

PHF5A
PHD finger-like domain-containing protein 5A

1

0

High-throughput

0.458

High

1384825

OTUL
Ubiquitin thioesterase otulin

1

0

Small-scale

0.458

High

1399102

SCLT1
Sodium channel and clathrin linker 1

1

0

High-throughput

0.458

High

1405738

KLF6
Krueppel-like factor 6

1

0

High-throughput

0.458

High

1407243

M3K3
Mitogen-activated protein kinase kinase kinase 3

1

0

High-throughput

0.458

High

1438723

CPAP
Centrosomal P4.1-associated protein

1

0

High-throughput

0.458

High

1447152

B9D1
B9 domain-containing protein 1

1

0

High-throughput

0.458

High

1447154

SAM50
Sorting and assembly machinery component 50 homolog

1

0

High-throughput

0.458

High

1447144

WSB2
WD repeat and SOCS box-containing protein 2

1

5

High-throughput

0.445

High

1244719

TTC33
Tetratricopeptide repeat protein 33

1

1

High-throughput

0.437

High

343067

HERC2
E3 ubiquitin-protein ligase HERC2

1

0

High-throughput

0.426

High

842871

CDN2A
Cyclin-dependent kinase inhibitor 2A

1

0

High-throughput

0.426

High

1370911

GCDH
Glutaryl-CoA dehydrogenase, mitochondrial

1

0

High-throughput

0.426

High

1218780

DC122
DDB1- and CUL4-associated factor 12-like protein 2

1

1

High-throughput

0.407

High

1438032

RC3H2
Roquin-2

3

0

High-throughput

0.347

High

1315058

ZZZ3
ZZ-type zinc finger-containing protein 3

2

0

High-throughput

0.328

High

1447142

FBX28
F-box only protein 28

2

0

High-throughput

0.328

High

641686

ERBB3
Receptor tyrosine-protein kinase erbB-3

2

0

High-throughput

0.300

High

1257230

NEK10
Serine/threonine-protein kinase Nek10

1

0

High-throughput

0.279

Low

1270337

SPT6H
Transcription elongation factor SPT6

1

0

High-throughput

0.279

Low

1329157

DB123
Beta-defensin 123

1

0

High-throughput

0.279

Low

254646

EIF1B
Eukaryotic translation initiation factor 1b

1

0

High-throughput

0.249

Low

318886

RHBT1
Rho-related BTB domain-containing protein 1

1

0

High-throughput

0.249

Low

1447150

ALK
ALK tyrosine kinase receptor

1

0

High-throughput

0.249

Low

694399

CO8A1
Collagen alpha-1(VIII) chain

1

0

High-throughput

0.232

Low

1384600

ESPB1
Epididymal sperm-binding protein 1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025