HitPredict

Interactor 1: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Interactor 2: DDR1 (Q08345)
Epithelial discoidin domain-containing receptor 1 (Epithelial discoidin domain receptor 1) (EC 2.7.10.1) (CD167 antigen-like family member A) (Cell adhesion kinase) (Discoidin receptor tyrosine kinase) (HGK2) (Mammary carcinoma kinase 10) (MCK-10) (Protein-tyrosine kinase 3A) (Protein-tyrosine kinase RTK-6) (TRK E) (Tyrosine kinase DDR) (Tyrosine-protein kinase CAK) (CD antigen CD167a)
Gene: DDR1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	22057045
Identification Methods	anti bait coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2, PK_Tyr_Ser-Thr~SH3_1
Common GO terms	GO:0005886 - plasma membrane GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 217 Hs			1 913
+	Hs
		924606 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		DDR2_HUMAN (20-905): 0: 843: 51.46
+	Hs
		994689 VAV3_HUMAN (1-212): 1.16e-43: 157: 22.00		DDR1_HUMAN (1-913): 0: 911: 100.00
+	Hs
		522887 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		SRC_HUMAN (361-912): 1.28e-125: 391: 23.60
+	Hs
		609244 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		FGFR3_HUMAN (551-905): 1.32e-110: 360: 32.16
+	Hs
		601492 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		FGFR2_HUMAN (583-905): 4.2e-109: 357: 34.05
+	Hs
		507939 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		FGFR1_HUMAN (540-905): 6.78e-109: 356: 32.52
+	Hs
		607935 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		FGFR4_HUMAN (554-910): 8.48e-107: 350: 33.87
+	Hs
		924603 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		NTRK2_HUMAN (604-906): 1.75e-104: 345: 43.89
+	Rn
		728442 GRB2_RAT (1-217): 6.71e-76: 229: 100.00		NTRK1_RAT (604-906): 3.59e-104: 343: 42.90
+	Dm
		993198 GRAP_DROME (1-215): 5.1e-62: 194: 62.79		CAD96_DROME (363-906): 5.41e-117: 377: 23.85
+	Hs
		411552 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		YES_HUMAN (563-907): 1.25e-105: 339: 31.59
+	Hs
		924601 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		NTRK3_HUMAN (607-905): 4.06e-67: 242: 43.63
+	Hs
		384619 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		NTRK1_HUMAN (607-902): 1.43e-66: 240: 45.27
+	Hs
		411352 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		INSR_HUMAN (600-908): 7.71e-53: 202: 37.42
+	Hs
		435602 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		IGF1R_HUMAN (600-908): 4.51e-51: 197: 37.22
+	Hs
		537729 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		INSRR_HUMAN (600-908): 2.79e-50: 194: 38.71
+	Hs
		924486 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		ROR2_HUMAN (608-905): 1.57e-50: 194: 38.26
+	Hs
		411523 VAV3_HUMAN (1-212): 1.16e-43: 157: 22.00		INSR_HUMAN (600-908): 7.71e-53: 202: 37.42
+	Hs
		445884 VAV3_HUMAN (1-212): 1.16e-43: 157: 22.00		ROS1_HUMAN (571-902): 5.2e-52: 201: 35.38
+	Hs
		435801 VAV3_HUMAN (1-212): 1.16e-43: 157: 22.00		IGF1R_HUMAN (600-908): 4.51e-51: 197: 37.22