HitPredict

Interactor 1: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Interactor 2: RGPS1 (Q5JS13)
Ras-specific guanine nucleotide-releasing factor RalGPS1 (Ral GEF with PH domain and SH3-binding motif 1) (Ral guanine nucleotide exchange factor 2) (RalGEF 2) (RalA exchange factor RalGPS1)
Gene: RALGPS1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	10747847
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PH~SH3_1
Common GO terms	GO:0005737 - cytoplasm GO:0005886 - plasma membrane GO:0007265 - Ras protein signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 217 Hs			1 557
+	Mm
		1141164 GRB2_MOUSE (1-217): 2.48e-76: 230: 99.54		RGPS2_MOUSE (7-557): 0: 559: 59.86
+	Hs
		557709 NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14		RGPS1_HUMAN (1-557): 0: 619: 100.00
+	Hs
		924511 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		SOS1_HUMAN (7-423): 3e-104: 343: 21.36
+	Mm
		1141134 GRB2_MOUSE (1-217): 2.48e-76: 230: 99.54		SOS1_MOUSE (7-394): 2.94e-103: 340: 21.72
+	Hs
		924512 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		SOS2_HUMAN (24-398): 4.35e-103: 339: 21.62
+	Mm
		970654 GRB2_MOUSE (1-217): 2.48e-76: 230: 99.54		SOS2_MOUSE (24-398): 5.04e-102: 337: 22.14
+	Hs
		992475 GRAP_HUMAN (1-213): 2.32e-66: 205: 56.74		SOS1_HUMAN (7-423): 3e-104: 343: 21.36
+	Hs
		924754 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		Q92942_HUMAN (83-454): 3.3e-97: 306: 21.34
+	Dm
		644366 GRAP_DROME (1-215): 5.1e-62: 194: 62.79		SOS_DROME (28-432): 4.47e-96: 322: 18.87
+	Hs
		924558 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		RPGF1_HUMAN (9-302): 1.49e-83: 283: 23.73
+	Mm
		1141157 GRB2_MOUSE (1-217): 2.48e-76: 230: 99.54		Q91ZZ2_MOUSE (9-302): 2.11e-81: 277: 23.73
+	Hs
		411690 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		SOS1_HUMAN (7-423): 3e-104: 343: 21.36
+	Hs
		557668 NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14		SOS1_HUMAN (7-423): 3e-104: 343: 21.36
+	Hs
		337446 ABL1_HUMAN (4-139): 4.39e-22: 95.5: 35.46		SOS1_HUMAN (7-423): 3e-104: 343: 21.36
+	Hs
		557669 NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14		SOS2_HUMAN (24-398): 4.35e-103: 339: 21.62
+	Hs
		337447 ABL1_HUMAN (4-139): 4.39e-22: 95.5: 35.46		SOS2_HUMAN (24-398): 4.35e-103: 339: 21.62
+	Hs
		557683 NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14		RPGF1_HUMAN (9-302): 1.49e-83: 283: 23.73
+	Mm
		337633 ABL1_MOUSE (4-139): 4.07e-22: 95.9: 35.46		Q8C5V7_MOUSE (8-302): 9.36e-86: 280: 23.65
+	Hs
		557756 NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14		RPGF5_HUMAN (5-289): 1.1e-81: 268: 22.22
+	Dm
		284703 GRAP_DROME (1-215): 5.1e-62: 194: 62.79		C3G_DROME (46-293): 3.5e-16: 84.3: 28.63